Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TTBK1
  • Mouse genes Ttbk1
  • Rat genes Ttbk1
  • Zfish genes ttbk1a,ttbk1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ttbk1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	Ttbk1	IPI	UniProtKB:Q9UPY8	Rat	PMID:26323690|RGD:13461759
Molecular Function	GO:0106310	protein serine kinase activity	TTBK1	IGI	RNAcentral:URS0000565C8D_9606	Human	PMID:30556160
Molecular Function	GO:0004674	protein serine/threonine kinase activity	TTBK1	IDA		Human	PMID:16923168
Molecular Function	GO:0004713	protein tyrosine kinase activity	TTBK1	IDA		Human	PMID:16923168
Molecular Function	GO:0048156	tau protein binding	TTBK1	IPI	UniProtKB:P10636	Human	PMID:16923168
Molecular Function	GO:0050321	tau-protein kinase activity	TTBK1	IDA		Human	PMID:16923168
Cellular Component	GO:0005829	cytosol	TTBK1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043025	neuronal cell body	TTBK1	IDA		Human	PMID:16923168
Cellular Component	GO:0043025	neuronal cell body	Ttbk1	IDA		Mouse	MGI:MGI:6102319|PMID:16923168
Cellular Component	GO:0005654	nucleoplasm	TTBK1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Ttbk1	IDA		Mouse	MGI:MGI:6102319|PMID:16923168
Biological Process	GO:0007611	learning or memory	TTBK1	IMP		Human	PMID:19118186
Biological Process	GO:0010629	negative regulation of gene expression	TTBK1	IMP		Human	PMID:19118186
Biological Process	GO:0032091	negative regulation of protein binding	TTBK1	IMP		Human	PMID:19118186
Biological Process	GO:0018105	peptidyl-serine phosphorylation	TTBK1	IDA		Human	PMID:16923168
Biological Process	GO:0018105	peptidyl-serine phosphorylation	TTBK1	IGI	RNAcentral:URS0000565C8D_9606	Human	PMID:30556160
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	TTBK1	IDA		Human	PMID:16923168
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	TTBK1	IDA		Human	PMID:16923168
Biological Process	GO:1904031	positive regulation of cyclin-dependent protein kinase activity	TTBK1	IMP		Human	PMID:19118186
Biological Process	GO:2001056	positive regulation of cysteine-type endopeptidase activity	TTBK1	IMP		Human	PMID:19118186
Biological Process	GO:0010628	positive regulation of gene expression	TTBK1	IMP		Human	PMID:19118186
Biological Process	GO:1903980	positive regulation of microglial cell activation	TTBK1	IMP		Human	PMID:19118186
Biological Process	GO:0032273	positive regulation of protein polymerization	TTBK1	IDA		Human	PMID:16923168
Biological Process	GO:0006468	protein phosphorylation	TTBK1	IMP		Human	PMID:19118186
Biological Process	GO:0021762	substantia nigra development	TTBK1	HEP		Human	PMID:22926577

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern