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Ttbk1 Gene Detail
Summary
  • Symbol
    Ttbk1
  • Name
    tau tubulin kinase 1
  • Synonyms
    C330008L01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2147036
    NCBI Gene: 106763
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr17:46442448-46487675 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 22.90 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    122 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2147036
protein coding gene Chr17:46442448-46487675 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023817
protein coding gene Chr17:47493575-47540618 (-)
A/J MGP_AJ_G0023775
protein coding gene Chr17:46362685-46408590 (-)
AKR/J MGP_AKRJ_G0023746
protein coding gene Chr17:46705134-46750203 (-)
BALB/cJ MGP_BALBcJ_G0023779
protein coding gene Chr17:46262184-46310541 (-)
C3H/HeJ MGP_C3HHeJ_G0023542
protein coding gene Chr17:47445530-47491009 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024222
protein coding gene Chr17:49554438-49600850 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021672
protein coding gene Chr17:43153160-43198316 (-)
CAST/EiJ MGP_CASTEiJ_G0023024
protein coding gene Chr17:47523027-47571852 (-)
CBA/J MGP_CBAJ_G0023519
protein coding gene Chr17:51331286-51376408 (-)
DBA/2J MGP_DBA2J_G0023645
protein coding gene Chr17:45143498-45189333 (-)
FVB/NJ MGP_FVBNJ_G0023612
protein coding gene Chr17:44756470-44802417 (-)
LP/J MGP_LPJ_G0023726
protein coding gene Chr17:48184065-48230185 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023641
protein coding gene Chr17:50888662-50935919 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024267
protein coding gene Chr17:47057629-47103693 (-)
PWK/PhJ MGP_PWKPhJ_G0022769
protein coding gene Chr17:44479024-44524178 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022584
protein coding gene Chr17:43931348-43980748 (-)
WSB/EiJ MGP_WSBEiJ_G0023089
protein coding gene Chr17:47603427-47651681 (-)



Homology
more
  • Human Ortholog
    TTBK1, tau tubulin kinase 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TTBK1, tau tubulin kinase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BDTK
  • Links
    NCBI Gene ID: 84630
    neXtProt AC: NX_Q5TCY1
    UniProt: Q5TCY1

  • Chr Location
    6p21.1; chr6:43243484-43288259 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 106763 NCBI Gene Model | MGI Sequence Detail 45228 C57BL/6J ±  kb
transcript NM_001162864 RefSeq | MGI Sequence Detail 6959 C57BL/6  
polypeptide Q6PCN3 UniProt | EBI | MGI Sequence Detail 1308 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 6
    cDNA 6

    Microarray probesets 4
Other
Accession IDs
less
MGI:2146972
References
more
  • Summaries
    All 30
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 3
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:206455 Asai H, et al., Accelerated Neurodegeneration and Neuroinflammation in Transgenic Mice Expressing P301L Tau Mutant and Tau-Tubulin Kinase 1. Am J Pathol. 2014 Mar;184(3):808-18

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory