Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TRPM8
  • Mouse genes Trpm8
  • Rat genes Trpm8
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Trpm8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005262	calcium channel activity	Trpm8	IDA		Mouse	PMID:17015441
Molecular Function	GO:0005262	calcium channel activity	Trpm8	IDA		Mouse	PMID:12654248
Molecular Function	GO:0005262	calcium channel activity	Trpm8	IMP	MGI:MGI:3716518	Mouse	PMID:17538622
Molecular Function	GO:0005262	calcium channel activity	Trpm8	IDA		Mouse	PMID:11893340
Molecular Function	GO:0042802	identical protein binding	Trpm8	IPI	PR:Q8R4D5	Mouse	PMID:17015441
Molecular Function	GO:0005216	monoatomic ion channel activity	Trpm8	IDA		Mouse	PMID:15194687
Molecular Function	GO:0005216	monoatomic ion channel activity	Trpm8	IDA		Rat	PMID:11882888|RGD:632416
Molecular Function	GO:0005515	protein binding	TRPM8	IPI	UniProtKB:A6NFQ2	Human	PMID:25559186
Molecular Function	GO:0005515	protein binding	Trpm8	IPI	PR:Q6QR59	Mouse	PMID:25559186
Molecular Function	GO:0005515	protein binding	Trpm8	IPI	PR:Q8BFY0	Mouse	PMID:18455988
Molecular Function	GO:0005515	protein binding	Trpm8	IPI	UniProtKB:P50148	Rat	PMID:22750945|RGD:13432341
Cellular Component	GO:0009897	external side of plasma membrane	Trpm8	IDA		Mouse	PMID:17015441
Cellular Component	GO:0016020	membrane	Trpm8	IDA		Mouse	PMID:11893340
Cellular Component	GO:0005886	plasma membrane	TRPM8	IDA		Human	PMID:25559186
Biological Process	GO:0006816	calcium ion transport	Trpm8	IDA		Mouse	PMID:17015441
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Trpm8	IDA		Mouse	PMID:11893340
Biological Process	GO:0034220	monoatomic ion transmembrane transport	Trpm8	IDA		Mouse	MGI:MGI:3053490|PMID:15194687
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	Trpm8	IMP		Mouse	MGI:MGI:6100983|PMID:22241835
Biological Process	GO:0009409	response to cold	Trpm8	IDA		Mouse	PMID:17015441
Biological Process	GO:0009409	response to cold	Trpm8	IMP	MGI:MGI:3716553	Mouse	PMID:17481392
Biological Process	GO:0009409	response to cold	Trpm8	IDA		Mouse	PMID:12654248
Biological Process	GO:0009409	response to cold	Trpm8	IMP	MGI:MGI:3716518	Mouse	PMID:17538622
Biological Process	GO:0009409	response to cold	Trpm8	IMP	MGI:MGI:3716558	Mouse	PMID:17481391
Biological Process	GO:0009409	response to cold	Trpm8	IDA		Rat	PMID:11882888|RGD:632416
Biological Process	GO:0009266	response to temperature stimulus	Trpm8	IDA		Mouse	PMID:11893340
Biological Process	GO:0050955	thermoception	Trpm8	IMP	MGI:MGI:3716518	Mouse	PMID:17538622
Biological Process	GO:0050955	thermoception	Trpm8	IMP	MGI:MGI:3716558	Mouse	PMID:17481391
Biological Process	GO:0050955	thermoception	Trpm8	IMP	MGI:MGI:3716553	Mouse	PMID:17481392
Biological Process	GO:0050955	thermoception	Trpm8	IDA		Mouse	PMID:12654248

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern