Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Trpm4

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes TRPM4
- Mouse genes Trpm4
- Rat genes Trpm4
- Zfish genes trpm4a,trpm4b.1,trpm4b.2
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Trpm4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	Trpm4	IDA		Mouse	MGI:MGI:6119829\|PMID:29211714
Molecular Function	GO:0005227	calcium activated cation channel activity	TRPM4	IDA		Human	PMID:27207958
Molecular Function	GO:0005227	calcium activated cation channel activity	TRPM4	IDA		Human	PMID:29211723
Molecular Function	GO:0005227	calcium activated cation channel activity	Trpm4	IDA		Mouse	MGI:MGI:4839447\|PMID:17188667
Molecular Function	GO:0005227	calcium activated cation channel activity	Trpm4	IDA		Mouse	MGI:MGI:6119829\|PMID:29211714
Molecular Function	GO:0005227	calcium activated cation channel activity	Trpm4	IDA		Rat	PMID:19945433\|RGD:8553249
Molecular Function	GO:0005227	calcium activated cation channel activity	trpm4a	IDA		Zfish	PMID:26432160
Molecular Function	GO:0005262	calcium channel activity	Trpm4	IDA		Mouse	PMID:12893253
Molecular Function	GO:0005509	calcium ion binding	TRPM4	IDA		Human	PMID:29217581
Molecular Function	GO:0005515	protein binding	TRPM4	IPI	UniProtKB:P05109	Human	PMID:31837246
Molecular Function	GO:0005515	protein binding	TRPM4	IPI	UniProtKB:P06703	Human	PMID:31837246
Molecular Function	GO:0005515	protein binding	TRPM4	IPI	UniProtKB:P26447	Human	PMID:31837246
Molecular Function	GO:0005515	protein binding	TRPM4	IPI	UniProtKB:P29034	Human	PMID:31837246
Molecular Function	GO:0005515	protein binding	TRPM4	IPI	UniProtKB:P31949	Human	PMID:31837246
Molecular Function	GO:0005515	protein binding	TRPM4	IPI	UniProtKB:P33763	Human	PMID:31837246
Molecular Function	GO:0005515	protein binding	TRPM4	IPI	UniProtKB:P33764	Human	PMID:31837246
Molecular Function	GO:0005515	protein binding	TRPM4	IPI	UniProtKB:P60903	Human	PMID:31837246
Molecular Function	GO:0005515	protein binding	Trpm4	IPI	RGD:3786	Rat	PMID:24114458\|RGD:10003028
Cellular Component	GO:0005829	cytosol	Trpm4	IDA		Rat	PMID:21406958\|RGD:10003034
Cellular Component	GO:0005783	endoplasmic reticulum	TRPM4	IDA		Human	PMID:19945433
Cellular Component	GO:0005783	endoplasmic reticulum	Trpm4	IDA		Rat	PMID:19945433\|RGD:8553249
Cellular Component	GO:0005794	Golgi apparatus	TRPM4	IDA		Human	PMID:19945433
Cellular Component	GO:0005794	Golgi apparatus	Trpm4	IDA		Rat	PMID:19945433\|RGD:8553249
Cellular Component	GO:0016020	membrane	TRPM4	IDA		Human	PMID:29217581
Cellular Component	GO:0043025	neuronal cell body	Trpm4	IDA		Rat	PMID:21848647\|RGD:10003044
Cellular Component	GO:0005654	nucleoplasm	TRPM4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	TRPM4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	TRPM4	IDA		Human	PMID:19945433
Cellular Component	GO:0005886	plasma membrane	TRPM4	IDA		Human	PMID:29211723
Cellular Component	GO:0005886	plasma membrane	Trpm4	IDA		Mouse	MGI:MGI:6119829\|PMID:29211714
Cellular Component	GO:0005886	plasma membrane	Trpm4	IDA		Mouse	PMID:12893253
Cellular Component	GO:0005886	plasma membrane	Trpm4	IDA		Rat	PMID:19945433\|RGD:8553249
Cellular Component	GO:0005886	plasma membrane	Trpm4	IDA		Rat	PMID:20610768\|RGD:9999443
Cellular Component	GO:0005886	plasma membrane	Trpm4	IDA		Rat	PMID:21406958\|RGD:10003034
Cellular Component	GO:0034706	sodium channel complex	TRPM4	IDA		Human	PMID:27207958
Biological Process	GO:0006816	calcium ion transport	Trpm4	IDA		Mouse	PMID:12893253
Biological Process	GO:0019722	calcium-mediated signaling	TRPM4	IDA		Human	PMID:27207958
Biological Process	GO:0071318	cellular response to ATP	Trpm4	IDA		Mouse	MGI:MGI:6119829\|PMID:29211714
Biological Process	GO:0002407	dendritic cell chemotaxis	Trpm4	IMP		Mouse	MGI:MGI:3815225\|PMID:18758465
Biological Process	GO:0098662	inorganic cation transmembrane transport	TRPM4	IDA		Human	PMID:29211723
Biological Process	GO:0098662	inorganic cation transmembrane transport	Trpm4	IDA		Mouse	MGI:MGI:6119829\|PMID:29211714
Biological Process	GO:0007616	long-term memory	Trpm4	IMP		Rat	PMID:29971514\|RGD:150521558
Biological Process	GO:0086045	membrane depolarization during AV node cell action potential	TRPM4	IMP		Human	PMID:27207958
Biological Process	GO:0086048	membrane depolarization during bundle of His cell action potential	TRPM4	IMP		Human	PMID:27207958
Biological Process	GO:0086047	membrane depolarization during Purkinje myocyte cell action potential	TRPM4	IMP		Human	PMID:27207958
Biological Process	GO:0098655	monoatomic cation transmembrane transport	trpm4a	IDA		Zfish	PMID:26432160\|ZFIN:ZDB-PUB-151004-5
Biological Process	GO:0030502	negative regulation of bone mineralization	Trpm4	IMP		Rat	PMID:23081848\|RGD:10003033
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	Trpm4	IMP		Rat	PMID:23081848\|RGD:10003033
Biological Process	GO:1904179	positive regulation of adipose tissue development	Trpm4	IMP		Rat	PMID:23081848\|RGD:10003033
Biological Process	GO:1903949	positive regulation of atrial cardiac muscle cell action potential	Trpm4	IMP		Rat	PMID:23954346\|RGD:10003031
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	TRPM4	IDA		Human	PMID:20625999
Biological Process	GO:0008284	positive regulation of cell population proliferation	TRPM4	IDA		Human	PMID:20625999
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Trpm4	IMP		Rat	PMID:23081848\|RGD:10003033
Biological Process	GO:0045600	positive regulation of fat cell differentiation	Trpm4	IMP		Rat	PMID:23081848\|RGD:10003033
Biological Process	GO:0010460	positive regulation of heart rate	Trpm4	IMP		Rat	PMID:23954346\|RGD:10003031
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	Trpm4	IMP		Rat	PMID:16806463\|RGD:10003029
Biological Process	GO:1904199	positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization	Trpm4	IMP		Rat	PMID:20826763\|RGD:10003037
Biological Process	GO:0045907	positive regulation of vasoconstriction	Trpm4	IMP		Rat	PMID:15472118\|RGD:10003027
Biological Process	GO:0045907	positive regulation of vasoconstriction	Trpm4	IMP		Rat	PMID:20610768\|RGD:9999443
Biological Process	GO:0051289	protein homotetramerization	TRPM4	IDA		Human	PMID:29211723
Biological Process	GO:0051289	protein homotetramerization	TRPM4	IDA		Human	PMID:29217581
Biological Process	GO:0051289	protein homotetramerization	Trpm4	IDA		Mouse	MGI:MGI:6119829\|PMID:29211714
Biological Process	GO:0016925	protein sumoylation	TRPM4	IDA		Human	PMID:19726882
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	TRPM4	IMP		Human	PMID:27207958
Biological Process	GO:0002724	regulation of T cell cytokine production	TRPM4	IDA		Human	PMID:20656926
Biological Process	GO:0098911	regulation of ventricular cardiac muscle cell action potential	TRPM4	IMP		Human	PMID:27207958
Biological Process	GO:0098719	sodium ion import across plasma membrane	TRPM4	IDA		Human	PMID:27207958

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/14/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.