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Trpm4
Gene Detail
Symbol

Name
ID
Trpm4
transient receptor potential cation channel, subfamily M, member 4
MGI:1915917
Synonyms
1110030C19Rik, LTRPC4, TRPM4B
Feature Type
protein coding gene
Genetic Map
Chromosome 7
29.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:45303155-45333780 bp, - strand
From Ensembl annotation of GRCm38

  30626 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23033  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 4 zebrafish

Protein SuperFamily: transient receptor potential cation channels TRPM4/TRPM5
Gene Tree: Trpm4

Human
homologs
Human Homolog TRPM4, transient receptor potential cation channel, subfamily M, member 4
NCBI Gene ID 54795
neXtProt AC  NX_Q8TD43
Human Synonyms  PFHB1B, TRPM4B
Human Chr (Location)  19q13.33; chr19:49157759-49211841 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human TRPM4
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(3) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele display increased Ca2+ influx and IgE-dependent mast cell activation, increased vascular permeability, and enhanced acute anaphylactic responses. Mice homozygous for a different knock-out allele show Ca2+ overload and impaired dendritic cell migration.
 
Interactions
Trpm4 interacts with 76 markers (Mir10a, Mir10b, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process calcium ion transmembrane transport, calcium ion transport, ...
Component endoplasmic reticulum, Golgi apparatus, ...
Function ATP binding, calcium activated cation channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (28)    Tissues (14)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 28
cDNA source data(43)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(45) cDNA(43) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000038260 (Evidence)
Entrez Gene68667 (Evidence)
UniGene439890
DFCITC1629029, TC1616830, TC1592882, TC1581717, TC1663234, TC1700381, TC1672363, TC1678381
DoTSDT.94123840, DT.91299696, DT.101719023, DT.91282379, DT.101387149, DT.94386335, DT.94339811, DT.99535898, DT.99853114
NIA Mouse Gene IndexU028523
Consensus CDS ProjectCCDS52245.1
International Mouse Knockout Project StatusTrpm4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000038260 Ensembl Gene Model | MGI Sequence Detail 30626 C57BL/6J ±  kb
transcript ENSMUST00000042194 Ensembl | MGI Sequence Detail 4245 Not Applicable 
polypeptide ENSMUSP00000040367 Ensembl | MGI Sequence Detail 1213 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(16) UniProt(1)
Polymorphisms
SNPs within 2kb(259 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005821 Ion transport domain
Protein Ontology PR:000016700 transient receptor potential cation channel subfamily M member 4
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:194095 Schattling B, et al., TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis. Nat Med. 2012 Dec;18(12):1805-11
All references(42)
Other
accession IDs
MGI:2142190

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory