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Trpm4
Gene Detail
 Symbol
Name
ID
Trpm4
transient receptor potential cation channel, subfamily M, member 4
MGI:1915917
Synonyms 1110030C19Rik, LTRPC4, TRPM4B
Feature Type protein coding gene
Genetic Map
Chromosome 7
29.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:45303155-45333780 bp, - strand
From NCBI annotation of GRCm38

  30626 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23033  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 4 zebrafish

Protein SuperFamily: transient receptor potential cation channels TRPM4/TRPM5
Gene Tree: Trpm4

Human
homologs
Human Homolog TRPM4, transient receptor potential cation channel, subfamily M, member 4
NCBI Gene ID 54795
neXtProt AC  NX_Q8TD43
Human Synonyms  PFHB1B, TRPM4B
Human Chr (Location)  19q13.33; chr19:49157759-49211841 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human TRPM4
Alleles
and
phenotypes
All alleles(10) : Targeted(7) Gene trapped(3)
 
Mice homozygous for a knock-out allele display increased Ca2+ influx and IgE-dependent mast cell activation, increased vascular permeability, and enhanced acute anaphylactic responses. Mice homozygous for a different knock-out allele show Ca2+ overload and impaired dendritic cell migration.
 
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process calcium ion transmembrane transport, calcium ion transport, ...
Component endoplasmic reticulum, Golgi apparatus, ...
Function ATP binding, calcium activated cation channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (28)    Tissues (11)    Images (2)
Theiler Stages: 20, 22, 25, 26, 28
Assay TypeResults
RT-PCR 28
cDNA source data(43)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(45) cDNA(43) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000038260 (Evidence)
Entrez Gene68667 (Evidence)
UniGene439890
DFCITC1581717, TC1592882, TC1616830, TC1629029, TC1663234, TC1672363, TC1678381, TC1700381
DoTSDT.101387149, DT.101719023, DT.91282379, DT.91299696, DT.94123840, DT.94339811, DT.94386335, DT.99535898, DT.99853114
NIA Mouse Gene IndexU028523
Consensus CDS ProjectCCDS52245.1
International Mouse Knockout Project StatusTrpm4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 68667 NCBI Gene Model | MGI Sequence Detail 30626 C57BL/6J ±  kb
transcript NM_175130 RefSeq | MGI Sequence Detail 4245 C57BL/6 
polypeptide Q7TN37 UniProt | EBI | MGI Sequence Detail 1213 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(16) UniProt(1)
Polymorphisms SNPs within 2kb(259 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005821 Ion transport domain
Protein Ontology PR:000016700 transient receptor potential cation channel subfamily M member 4
Graphical View of Protein Domain Structure
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:194095 Schattling B, et al., TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis. Nat Med. 2012 Dec;18(12):1805-11
All references(42)
Other
accession IDs
MGI:2142190

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory