Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TRPC6
  • Mouse genes Trpc6
  • Rat genes Trpc6
  • Zfish genes trpc6a,trpc6b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Trpc6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003779	actin binding	Trpc6	IDA		Rat	PMID:16025302|RGD:10043786
Molecular Function	GO:0042805	actinin binding	Trpc6	IDA		Rat	PMID:16025302|RGD:10043786
Molecular Function	GO:0051117	ATPase binding	Trpc6	IPI	RGD:2167	Rat	PMID:16025302|RGD:10043786
Molecular Function	GO:0051117	ATPase binding	Trpc6	IPI	RGD:2169	Rat	PMID:16025302|RGD:10043786
Molecular Function	GO:0005262	calcium channel activity	Trpc6	IDA		Rat	PMID:20501650|RGD:7242941
Molecular Function	GO:0030276	clathrin binding	Trpc6	IDA		Rat	PMID:16025302|RGD:10043786
Molecular Function	GO:0070679	inositol 1,4,5 trisphosphate binding	TRPC6	IDA		Human	PMID:14505576
Molecular Function	GO:0005261	monoatomic cation channel activity	TRPC6	IDA		Human	PMID:19936226
Molecular Function	GO:0005261	monoatomic cation channel activity	TRPC6	IDA		Human	PMID:23291369
Molecular Function	GO:0005261	monoatomic cation channel activity	Trpc6	IDA		Rat	PMID:11278449|RGD:634440
Molecular Function	GO:0005216	monoatomic ion channel activity	Trpc6	IDA		Mouse	PMID:15194687
Molecular Function	GO:0005515	protein binding	TRPC6	IPI	UniProtKB:P20591	Human	PMID:15757897
Molecular Function	GO:0005515	protein binding	TRPC6	IPI	UniProtKB:Q96H20	Human	PMID:23171048
Molecular Function	GO:0005515	protein binding	Trpc6	IPI	UniProtKB:Q96D31	Mouse	MGI:MGI:6093108|PMID:17360584
Molecular Function	GO:0005515	protein binding	Trpc6	IPI	PR:Q9QZS7	Mouse	PMID:15924139
Molecular Function	GO:0005515	protein binding	Trpc6	IPI	PR:Q91X05	Mouse	PMID:15924139
Molecular Function	GO:0005515	protein binding	Trpc6	IPI	RGD:70885	Rat	PMID:16025302|RGD:10043786
Molecular Function	GO:0005515	protein binding	Trpc6	IPI	RGD:71096	Rat	PMID:16025302|RGD:10043786
Molecular Function	GO:0042803	protein homodimerization activity	TRPC6	IDA		Human	PMID:23291369
Molecular Function	GO:0015279	store-operated calcium channel activity	Trpc6	IDA		Mouse	PMID:8646775
Cellular Component	GO:0005737	cytoplasm	TRPC6	IDA		Human	PMID:23171048
Cellular Component	GO:0016020	membrane	TRPC6	IDA		Human	PMID:23171048
Cellular Component	GO:0005886	plasma membrane	TRPC6	IDA		Human	PMID:10998353
Cellular Component	GO:0005886	plasma membrane	TRPC6	IDA		Human	PMID:23291369
Cellular Component	GO:0005886	plasma membrane	Trpc6	IDA		Mouse	PMID:15924139
Cellular Component	GO:0005886	plasma membrane	Trpc6	IDA		Rat	PMID:20501650|RGD:7242941
Cellular Component	GO:0036057	slit diaphragm	Trpc6	IDA		Mouse	PMID:15924139
Biological Process	GO:0007568	aging	Trpc6	IEP		Rat	PMID:20431989|RGD:7247586
Biological Process	GO:0070301	cellular response to hydrogen peroxide	Trpc6	IDA		Rat	PMID:20501650|RGD:7242941
Biological Process	GO:0071456	cellular response to hypoxia	Trpc6	IEP		Rat	PMID:19889962|RGD:7247600
Biological Process	GO:0050774	negative regulation of dendrite morphogenesis	Trpc6	IMP		Rat	PMID:22764246|RGD:10044012
Biological Process	GO:0030182	neuron differentiation	Trpc6	IEP		Rat	PMID:20479868|RGD:10044014
Biological Process	GO:0051928	positive regulation of calcium ion transport	TRPC6	IDA		Human	PMID:10998353
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Trpc6	IDA		Mouse	PMID:9368034
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Trpc6	IDA		Rat	PMID:11788346|RGD:619540
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Trpc6	IMP		Rat	PMID:22764246|RGD:10044012
Biological Process	GO:0032414	positive regulation of ion transmembrane transporter activity	TRPC6	IDA		Human	PMID:10998353
Biological Process	GO:0045666	positive regulation of neuron differentiation	Trpc6	IMP		Rat	PMID:20479868|RGD:10044014
Biological Process	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	Trpc6	IMP		Rat	PMID:22699894|RGD:10044018

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern