About   Help   FAQ
Trpc6
Gene Detail
Symbol

Name
ID
Trpc6
transient receptor potential cation channel, subfamily C, member 6
MGI:109523
Synonyms
mtrp6, Trrp6
Feature Type
protein coding gene
Genetic Map
Chromosome 9
2.46 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr9:8544196-8680565 bp, + strand
From Ensembl annotation of GRCm38

  136370 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37944  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: TRPC6
Protein SuperFamily: transient receptor potential cation channel, subfamily C
Gene Tree: Trpc6

Human
homologs
TRPC6, transient receptor potential cation channel, subfamily C, member 6
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7225
neXtProt AC: NX_Q9Y210

Human Synonyms: FSGS2, TRP6

Human Chr (Location): 11q22.1; chr11:101451564-101584018 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TRPC6

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(3) Transgenic(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for one null targeted mutation are viable and fertile and exhibit no overt abnormal phenotype. Another knockout results in an increase in thermal nociceptive response latency.
 
Human Diseases Modeled in Mice Using Trpc6 (1)    Mutations Annotated to Human Diseases (3)   
Interactions
Trpc6 interacts with 6 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (38 annotations)
Process calcium ion transmembrane transport, calcium ion transport, ...
Component cytoplasm, cytosol, ...
Function actin binding, actinin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (53)    Tissues (16)    Images (28)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
RT-PCR 29
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase trpc6 ; ZFIN trpc6a, trpc6b    NEW 
Molecular
reagents
All nucleic(14) Genomic(1) cDNA(10) Primer pair(3)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000031997 (Evidence)
Entrez Gene 22068 (Evidence)
UniGene 325086
DFCI TC1588122
DoTS DT.97355895, DT.91446636, DT.60102999, DT.102553774
NIA Mouse Gene Index U010030
Consensus CDS Project CCDS22815.1
International Mouse Phenotyping Consortium Status Trpc6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031997 Ensembl Gene Model | MGI Sequence Detail 136370 C57BL/6J ±  kb
transcript ENSMUST00000050433 Ensembl | MGI Sequence Detail 3029 Not Applicable 
polypeptide ENSMUSP00000057965 Ensembl | MGI Sequence Detail 930 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(14) UniProt(3)
Polymorphisms
PCR(1) : SNPs within 2kb(321 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR005821 Ion transport domain
InterPro IPR013555 Transient receptor ion channel domain
InterPro IPR004729 Transient receptor potential channel
InterPro IPR002153 Transient receptor potential channel, canonical
InterPro IPR005462 Transient receptor potential channel, canonical 6
Protein Ontology PR:000016696 short transient receptor potential channel 6
References
(Earliest) J:33403 Zhu X, et al., trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry. Cell. 1996 May 31;85(5):661-71
(Latest) J:218743 Lutas A, et al., Metabolism regulates the spontaneous firing of substantia nigra pars reticulata neurons via KATP and nonselective cation channels. J Neurosci. 2014 Dec 3;34(49):16336-47
All references(77)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-39522, MGI:2143254

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory