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Trpc6
Gene Detail
 Symbol
Name
ID
Trpc6
transient receptor potential cation channel, subfamily C, member 6
MGI:109523
Synonyms mtrp6, Trrp6
Feature Type protein coding gene
Genetic Map
Chromosome 9
2.46 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr9:8544196-8680565 bp, + strand
From Ensembl annotation of GRCm38

  136370 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37944  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: transient receptor potential cation channel, subfamily C
Gene Tree: Trpc6

Human
homologs
Human Homolog TRPC6, transient receptor potential cation channel, subfamily C, member 6
NCBI Gene ID 7225
neXtProt AC  NX_Q9Y210
Human Synonyms  FSGS2, TRP6
Human Chr (Location)  11q22.1; chr11:101451564-101583956 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human TRPC6
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for one null targeted mutation are viable and fertile and exhibit no overt abnormal phenotype. Another knockout results in an increase in thermal nociceptive response latency.
 
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process calcium ion transmembrane transport, calcium ion transport, ...
Component integral component of membrane, integral component of plasma membrane, ...
Function calcium channel activity, cation channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (53)    Tissues (13)    Images (28)
Theiler Stages: 20, 22, 23, 25, 26, 28
Assay TypeResults
RNA in situ 24
RT-PCR 29
cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(14) Genomic(1) cDNA(10) Primer pair(3)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000031997 (Evidence)
Entrez Gene22068 (Evidence)
UniGene325086
DFCITC1588122
DoTSDT.102553774, DT.60102999, DT.91446636, DT.97355895
NIA Mouse Gene IndexU010030
Consensus CDS ProjectCCDS22815.1
International Mouse Knockout Project StatusTrpc6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031997 Ensembl Gene Model | MGI Sequence Detail 136370 C57BL/6J ±  kb
transcript ENSMUST00000050433 Ensembl | MGI Sequence Detail 3029 Not Applicable 
polypeptide ENSMUSP00000057965 Ensembl | MGI Sequence Detail 930 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(12) UniProt(3)
Polymorphisms PCR(1) : SNPs within 2kb(321 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR005821 Ion transport domain
InterPro IPR013555 Transient receptor ion channel domain
InterPro IPR004729 Transient receptor potential channel
InterPro IPR002153 Transient receptor potential channel, canonical
InterPro IPR005462 Transient receptor potential channel, canonical 6
Protein Ontology PR:000016696 short transient receptor potential channel 6
References (Earliest) J:33403 Zhu X, et al., trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry. Cell. 1996 May 31;85(5):661-71
(Latest) J:210844 Albarran L, et al., TRPC6 participates in the regulation of cytosolic basal calcium concentration in murine resting platelets. Biochim Biophys Acta. 2014 Apr;1843(4):789-96
All references(69)
Other
accession IDs
MGD-MRK-39522, MGI:2143254

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory