Trpc6
Gene Detail

Symbol Name ID

Trpc6 transient receptor potential cation channel, subfamily C, member 6 MGI:109523

Synonyms

mtrp6, Trrp6

Feature Type

protein coding gene

Genetic Map

Chromosome 9

2.46 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr9:8544196-8680565 bp, + strand From Ensembl annotation of GRCm38   136370 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37944  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: transient receptor potential cation channel, subfamily C
Gene Tree: Trpc6

Human homologs

Human Homolog		TRPC6, transient receptor potential cation channel, subfamily C, member 6
NCBI Gene ID		7225
neXtProt AC		NX_Q9Y210
Human Synonyms		FSGS2, TRP6
Human Chr (Location)		11q22.1; chr11:101322295-101454659 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TRPC6

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for one null targeted mutation are viable and fertile and exhibit no overt abnormal phenotype. Another knockout results in an increase in thermal nociceptive response latency.

 

Gene Ontology (GO) classifications

All GO classifications: (29 annotations)

Process	calcium ion transmembrane transport, calcium ion transport, ...
Component	integral to membrane, integral to plasma membrane, ...
Function	calcium channel activity, cation channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (53)    Tissues (13)    Images (28)
Theiler Stages: 20, 22, 23, 25, 26, 28

Assay Type	Results
RNA in situ	24
RT-PCR	29

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(14) Genomic(1) cDNA(10) Primer pair(3)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000031997 (Evidence)
Entrez Gene	22068 (Evidence)
UniGene	325086
DFCI	TC1588122
DoTS	DT.102553774, DT.60102999, DT.91446636, DT.97355895
NIA Mouse Gene Index	U010030
Consensus CDS Project	CCDS22815.1
International Mouse Knockout Project Status	Trpc6

Sequences

Length	Strain/Species
genomic	ENSMUSG00000031997	Ensembl Gene Model | MGI Sequence Detail	136370	C57BL/6J
transcript	ENSMUST00000050433	Ensembl | MGI Sequence Detail	3029	Not Applicable
polypeptide	ENSMUSP00000057965	Ensembl | MGI Sequence Detail	930	Not Applicable

All sequences(23) RefSeq(2) UniProt(3)

Polymorphisms

PCR(1) : SNPs(281 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002110	Ankyrin repeat
InterPro	IPR020683	Ankyrin repeat-containing domain
InterPro	IPR005821	Ion transport domain
InterPro	IPR013555	Transient receptor ion channel domain
InterPro	IPR004729	Transient receptor potential channel
InterPro	IPR002153	Transient receptor potential channel, canonical
InterPro	IPR005462	Transient receptor potential channel, canonical 6
Protein Ontology	PR:000016696	transient receptor potential cation channel TRPC6

References

(Earliest) J:33403 Zhu X, et al., trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry. Cell. 1996 May 31;85(5):661-71
(Latest) J:190916 Li H, et al., TRPC6 inhibited NMDA receptor activities and protected neurons from ischemic excitotoxicity. J Neurochem. 2012 Dec;123(6):1010-8
All references(65)

Other accession IDs

MGD-MRK-39522, MGI:2143254