Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TRPC1
  • Mouse genes Trpc1
  • Rat genes Trpc1
  • Zfish genes trpc1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Trpc1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051117	ATPase binding	TRPC1	IPI	UniProtKB:P16615	Human	PMID:18068335
Molecular Function	GO:0051117	ATPase binding	TRPC1	IPI	UniProtKB:Q93084	Human	PMID:18068335
Molecular Function	GO:0070679	inositol 1,4,5 trisphosphate binding	TRPC1	IDA		Human	PMID:14505576
Molecular Function	GO:0005261	monoatomic cation channel activity	TRPC1	EXP		Human	PMID:18995841
Molecular Function	GO:0005515	protein binding	TRPC1	IPI	UniProtKB:Q13563	Human	PMID:10097141
Molecular Function	GO:0005515	protein binding	TRPC1	IPI	UniProtKB:Q86YM7	Human	PMID:14505576
Molecular Function	GO:0005515	protein binding	TRPC1	IPI	UniProtKB:Q03135	Human	PMID:19052258
Molecular Function	GO:0005515	protein binding	TRPC1	IPI	UniProtKB:Q14573	Human	PMID:19052258
Molecular Function	GO:0005515	protein binding	TRPC1	IPI	UniProtKB:Q03135	Human	PMID:19897728
Molecular Function	GO:0005515	protein binding	TRPC1	IPI	UniProtKB:Q13586	Human	PMID:19897728
Molecular Function	GO:0005515	protein binding	TRPC1	IPI	UniProtKB:Q13586	Human	PMID:21408196
Molecular Function	GO:0005515	protein binding	TRPC1	IPI	UniProtKB:Q96D31	Human	PMID:21408196
Molecular Function	GO:0005515	protein binding	TRPC1	IPI	UniProtKB:Q13563	Human	PMID:25114176
Molecular Function	GO:0005515	protein binding	TRPC1	IPI	UniProtKB:Q9EPK8	Human	PMID:25114176
Molecular Function	GO:0005515	protein binding	Trpc1	IPI	UniProtKB:Q9JJ00	Mouse	MGI:MGI:6450314|PMID:32110987
Molecular Function	GO:0005515	protein binding	Trpc1	IPI	PR:Q9QUQ5	Mouse	PMID:17416589
Molecular Function	GO:0005515	protein binding	Trpc1	IPI	PR:P49817	Mouse	PMID:17416589
Molecular Function	GO:0005515	protein binding	Trpc1	IPI	PR:Q9Z2Y3	Mouse	PMID:18268005
Molecular Function	GO:0005515	protein binding	Trpc1	IPI	PR:Q6SP97	Mouse	PMID:15385169
Molecular Function	GO:0005515	protein binding	Trpc1	IPI	PR:P11881	Mouse	PMID:17416589
Molecular Function	GO:0005102	signaling receptor binding	TRPC1	IPI	UniProtKB:Q14571	Human	PMID:18068335
Molecular Function	GO:0015279	store-operated calcium channel activity	Trpc1	IMP	MGI:MGI:3764882	Mouse	PMID:17956991
Cellular Component	GO:0016323	basolateral plasma membrane	Trpc1	IMP	MGI:MGI:3764882	Mouse	PMID:17956991
Cellular Component	GO:0043034	costamere	Trpc1	IDA		Mouse	PMID:18268005
Cellular Component	GO:0005737	cytoplasm	Trpc1	IDA		Mouse	PMID:15044151
Cellular Component	GO:0045121	membrane raft	Trpc1	IDA		Mouse	PMID:17416589
Cellular Component	GO:0005886	plasma membrane	TRPC1	IDA		Human	PMID:14505576
Cellular Component	GO:0032991	protein-containing complex	Trpc1	IPI	PR:P11881	Mouse	PMID:17416589
Cellular Component	GO:0032991	protein-containing complex	Trpc1	IPI	PR:Q9QUQ5	Mouse	PMID:17416589
Cellular Component	GO:0032991	protein-containing complex	Trpc1	IPI	PR:P49817	Mouse	PMID:17416589
Cellular Component	GO:0043235	receptor complex	TRPC1	IDA		Human	PMID:23382219
Cellular Component	GO:0030017	sarcomere	Trpc1	IDA		Mouse	PMID:18268005
Biological Process	GO:0001525	angiogenesis	trpc1	IMP	ZFIN:ZDB-MRPHLNO-100621-1	Zfish	PMID:20185799
Biological Process	GO:0071456	cellular response to hypoxia	Trpc1	IEP		Rat	PMID:19889962|RGD:7247600
Biological Process	GO:0046847	filopodium assembly	trpc1	IMP	ZFIN:ZDB-MRPHLNO-100621-1	Zfish	PMID:20185799
Biological Process	GO:0042438	melanin biosynthetic process	TRPC1	IDA		Human	PMID:8126111
Biological Process	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	TRPC1	IDA		Human	PMID:19052258
Biological Process	GO:0051480	regulation of cytosolic calcium ion concentration	TRPC1	IDA		Human	PMID:19052258
Biological Process	GO:0051592	response to calcium ion	TRPC1	IDA		Human	PMID:14505576
Biological Process	GO:0051592	response to calcium ion	TRPC1	IDA		Human	PMID:19052258
Biological Process	GO:0046541	saliva secretion	Trpc1	IMP	MGI:MGI:3764882	Mouse	PMID:17956991
Biological Process	GO:0001570	vasculogenesis	trpc1	IMP	ZFIN:ZDB-MRPHLNO-100621-1	Zfish	PMID:20185799

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern