About   Help   FAQ
Trpc1
Gene Detail
Symbol

Name
ID
Trpc1
transient receptor potential cation channel, subfamily C, member 1
MGI:109528
Synonyms
Mtrp1, Trp1, Trrp1
Feature Type
protein coding gene
Genetic Map
Chromosome 9
50.20 cM, cytoband E4
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr9:95705082-95750375 bp, - strand
From VEGA annotation of GRCm38

  45294 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2478  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transient receptor potential cation channel, subfamily C
Gene Tree: Trpc1

Human
homologs
Human Homolog TRPC1, transient receptor potential cation channel, subfamily C, member 1
NCBI Gene ID 7220
neXtProt AC  NX_P48995
Human Synonyms  HTRP-1, TRP1
Human Chr (Location)  3q23; chr3:142724424-142807888 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit increased body weight and a severe loss of salivary gland fluid secretion due to attenuation of store-operated Ca2+ currents. Surprisingly, no abnormalities are seen in store-operated or mechanosensitive cation channels in vascular smooth muscle cells.
 
Interactions
Trpc1 interacts with 54 markers (Mir25, Mir30a, Mir30d, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process calcium ion transmembrane transport, calcium ion transport, ...
Component basolateral plasma membrane, costamere, ...
Function calcium channel activity, cation channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (36)    Tissues (15)    Images (12)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 7
RT-PCR 29
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) Genomic(2) cDNA(13) Primer pair(4)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000047293 (Evidence)
Ensembl Gene ModelENSMUSG00000032839 (Evidence)
Entrez Gene22063 (Evidence)
DFCITC1594298, TC1589396, TC1595343, TC1606639, TC1604298
DoTSDT.97410206, DT.40151165, DT.91336735, DT.91332727, DT.91329384
NIA Mouse Gene IndexU031201
Consensus CDS ProjectCCDS23411.1
International Mouse Knockout Project StatusTrpc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000047293 VEGA Gene Model | MGI Sequence Detail 45294 C57BL/6J ±  kb
transcript OTTMUST00000122275 VEGA | MGI Sequence Detail 4559 Not Applicable 
polypeptide OTTMUSP00000067131 VEGA | MGI Sequence Detail 809 Not Applicable 

For the selected sequences
All sequences(62) RefSeq(12) UniProt(8)
Polymorphisms
PCR(1) : SNPs within 2kb(602 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR005821 Ion transport domain
InterPro IPR013555 Transient receptor ion channel domain
InterPro IPR004729 Transient receptor potential channel
InterPro IPR002153 Transient receptor potential channel, canonical
InterPro IPR005457 Transient receptor potential channel, canonical 1
Protein Ontology PR:000016693 short transient receptor potential channel 1
References
(Earliest) J:33403 Zhu X, et al., trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry. Cell. 1996 May 31;85(5):661-71
(Latest) J:211710 Py BF, et al., Caspase-11 controls interleukin-1beta release through degradation of TRPC1. Cell Rep. 2014 Mar 27;6(6):1122-8
All references(68)
Other
accession IDs
MGD-MRK-39527

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/11/2014
MGI 5.20
The Jackson Laboratory