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Trpc1
Gene Detail
Symbol

Name
ID
Trpc1
transient receptor potential cation channel, subfamily C, member 1
MGI:109528
Synonyms
Mtrp1, Trp1, Trrp1
Feature Type
protein coding gene
Genetic Map
Chromosome 9
50.20 cM, cytoband E4
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr9:95705082-95750375 bp, - strand
From VEGA annotation of GRCm38

  45294 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2478  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TRPC1
Protein SuperFamily: transient receptor potential cation channel, subfamily C
Gene Tree: Trpc1

Human
homologs
TRPC1, transient receptor potential cation channel, subfamily C, member 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7220
neXtProt AC: NX_P48995

Human Synonyms: HTRP-1, TRP1

Human Chr (Location): 3q23; chr3:142724032-142807888 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit increased body weight and a severe loss of salivary gland fluid secretion due to attenuation of store-operated Ca2+ currents. Surprisingly, no abnormalities are seen in store-operated or mechanosensitive cation channels in vascular smooth muscle cells.
 
Interactions
Trpc1 interacts with 53 markers (Mir25, Mir30a, Mir30d, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process calcium ion transmembrane transport, calcium ion transport, ...
Component basolateral plasma membrane, costamere, ...
Function calcium channel activity, cation channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (36)    Tissues (15)    Images (12)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 7
RT-PCR 29
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase trpc1 ; ZFIN trpc1    NEW 
Molecular
reagents
All nucleic(19) Genomic(2) cDNA(13) Primer pair(4)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000047293 (Evidence)
Ensembl Gene Model ENSMUSG00000032839 (Evidence)
Entrez Gene 22063 (Evidence)
DFCI TC1589396, TC1594298, TC1595343, TC1604298, TC1606639
DoTS DT.40151165, DT.91329384, DT.91332727, DT.91336735, DT.97410206
NIA Mouse Gene Index U031201
Consensus CDS Project CCDS23411.1
International Mouse Phenotyping Consortium Status Trpc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000047293 VEGA Gene Model | MGI Sequence Detail 45294 C57BL/6J ±  kb
transcript OTTMUST00000122275 VEGA | MGI Sequence Detail 4559 Not Applicable 
polypeptide OTTMUSP00000067131 VEGA | MGI Sequence Detail 809 Not Applicable 

For the selected sequences
All sequences(74) RefSeq(15) UniProt(6)
Polymorphisms
PCR(1) : SNPs within 2kb(602 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR005821 Ion transport domain
InterPro IPR013555 Transient receptor ion channel domain
InterPro IPR004729 Transient receptor potential channel
InterPro IPR002153 Transient receptor potential channel, canonical
InterPro IPR005457 Transient receptor potential channel, canonical 1
Protein Ontology PR:000016693 short transient receptor potential channel 1
References
(Earliest) J:33403 Zhu X, et al., trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry. Cell. 1996 May 31;85(5):661-71
(Latest) J:218743 Lutas A, et al., Metabolism regulates the spontaneous firing of substantia nigra pars reticulata neurons via KATP and nonselective cation channels. J Neurosci. 2014 Dec 3;34(49):16336-47
All references(70)
Other
accession IDs
MGD-MRK-39527

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory