Trpc1
Gene Detail

Symbol Name ID

Trpc1 transient receptor potential cation channel, subfamily C, member 1 MGI:109528

Synonyms

Mtrp1, Trp1, Trrp1

Feature Type

protein coding gene

Genetic Map

Chromosome 9

50.20 cM, cytoband E4
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr9:95706627-95750358 bp, - strand From NCBI annotation of GRCm38   43732 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2478  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: transient receptor potential cation channel, subfamily C
Gene Tree: Trpc1

Human homologs

Human Homolog		TRPC1, transient receptor potential cation channel, subfamily C, member 1
NCBI Gene ID		7220
neXtProt AC		NX_P48995
Human Synonyms		HTRP-1, TRP1
Human Chr (Location)		3q23; chr3:142443266-142526730 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for a knock-out allele exhibit increased body weight and a severe loss of salivary gland fluid secretion due to attenuation of store-operated Ca2+ currents. Surprisingly, no abnormalities are seen in store-operated or mechanosensitive cation channels in vascular smooth muscle cells.

 

Gene Ontology (GO) classifications

All GO classifications: (31 annotations)

Process	calcium ion transmembrane transport, calcium ion transport, ...
Component	basolateral plasma membrane, costamere, ...
Function	calcium channel activity, cation channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (36)    Tissues (12)    Images (12)
Theiler Stages: 20, 22, 25, 26, 28

Assay Type	Results
RNA in situ	7
RT-PCR	29

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(19) Genomic(2) cDNA(13) Primer pair(4)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000032839 (Evidence)
Entrez Gene	22063 (Evidence)
DFCI	TC1589396, TC1594298, TC1595343, TC1604298, TC1606639
DoTS	DT.40151165, DT.91329384, DT.91332727, DT.91336735, DT.97410206
NIA Mouse Gene Index	U031201
Consensus CDS Project	CCDS23411.1
International Mouse Knockout Project Status	Trpc1

Sequences

Length	Strain/Species
genomic	22063	NCBI Gene Model | MGI Sequence Detail	43732	C57BL/6J
transcript	NM_011643	RefSeq | MGI Sequence Detail	3014	C57BL/6
polypeptide	Q61056	UniProt | EBI | MGI Sequence Detail	793	Not Applicable

All sequences(34) RefSeq(2) UniProt(3)

Polymorphisms

PCR(1) : SNPs(273 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002110	Ankyrin repeat
InterPro	IPR020683	Ankyrin repeat-containing domain
InterPro	IPR005821	Ion transport domain
InterPro	IPR013555	Transient receptor ion channel domain
InterPro	IPR004729	Transient receptor potential channel
InterPro	IPR002153	Transient receptor potential channel, canonical
InterPro	IPR005457	Transient receptor potential channel, canonical 1
Protein Ontology	PR:000016693	short transient receptor potential channel 1

Graphical View of Protein Domain Structure

References

(Earliest) J:33403 Zhu X, et al., trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry. Cell. 1996 May 31;85(5):661-71
(Latest) J:194590 Phelan KD, et al., Canonical transient receptor channel 5 (TRPC5) and TRPC1/4 contribute to seizure and excitotoxicity by distinct cellular mechanisms. Mol Pharmacol. 2013 Feb;83(2):429-38
All references(59)

Other accession IDs

MGD-MRK-39527