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Trpc1
Gene Detail
 Symbol
Name
ID
Trpc1
transient receptor potential cation channel, subfamily C, member 1
MGI:109528
Synonyms Mtrp1, Trp1, Trrp1
Feature Type protein coding gene
Genetic Map
Chromosome 9
50.20 cM, cytoband E4
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr9:95706627-95750358 bp, - strand
From NCBI annotation of GRCm38

  43732 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2478  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: transient receptor potential cation channel, subfamily C
Gene Tree: Trpc1

Human
homologs
Human Homolog TRPC1, transient receptor potential cation channel, subfamily C, member 1
NCBI Gene ID 7220
neXtProt AC  NX_P48995
Human Synonyms  HTRP-1, TRP1
Human Chr (Location)  3q23; chr3:142724424-142807888 (+)  GRCh38
Alleles
and
phenotypes
All alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit increased body weight and a severe loss of salivary gland fluid secretion due to attenuation of store-operated Ca2+ currents. Surprisingly, no abnormalities are seen in store-operated or mechanosensitive cation channels in vascular smooth muscle cells.
 
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process calcium ion transmembrane transport, calcium ion transport, ...
Component basolateral plasma membrane, costamere, ...
Function calcium channel activity, cation channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (36)    Tissues (12)    Images (12)
Theiler Stages: 20, 22, 25, 26, 28
Assay TypeResults
RNA in situ 7
RT-PCR 29
cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(19) Genomic(2) cDNA(13) Primer pair(4)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000032839 (Evidence)
Entrez Gene22063 (Evidence)
DFCITC1589396, TC1594298, TC1595343, TC1604298, TC1606639
DoTSDT.40151165, DT.91329384, DT.91332727, DT.91336735, DT.97410206
NIA Mouse Gene IndexU031201
Consensus CDS ProjectCCDS23411.1
International Mouse Knockout Project StatusTrpc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 22063 NCBI Gene Model | MGI Sequence Detail 43732 C57BL/6J ±  kb
transcript NM_011643 RefSeq | MGI Sequence Detail 3014 C57BL/6 
polypeptide Q61056 UniProt | EBI | MGI Sequence Detail 793 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(12) UniProt(3)
Polymorphisms PCR(1) : SNPs within 2kb(589 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR005821 Ion transport domain
InterPro IPR013555 Transient receptor ion channel domain
InterPro IPR004729 Transient receptor potential channel
InterPro IPR002153 Transient receptor potential channel, canonical
InterPro IPR005457 Transient receptor potential channel, canonical 1
Protein Ontology PR:000016693 short transient receptor potential channel 1
Graphical View of Protein Domain Structure
References (Earliest) J:33403 Zhu X, et al., trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry. Cell. 1996 May 31;85(5):661-71
(Latest) J:203802 Shi J, et al., Myristoylated alanine-rich C kinase substrate coordinates native TRPC1 channel activation by phosphatidylinositol 4,5-bisphosphate and protein kinase C in vascular smooth muscle. FASEB J. 2014 Jan;28(1):244-55
All references(64)
Other
accession IDs
MGD-MRK-39527

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory