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Trpc1 Gene Detail
Summary
  • Symbol
    Trpc1
  • Name
    transient receptor potential cation channel, subfamily C, member 1
  • Synonyms
    Mtrp1, Trp1, Trrp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:109528
    NCBI Gene: 22063
  • Gene Overview
    MyGene.info: TRPC1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:95705082-95750375 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      45294 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 50.20 cM, cytoband E4
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    TRPC1, transient receptor potential cation channel subfamily C member 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TRPC1, transient receptor potential cation channel subfamily C member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HTRP-1, TRP1
  • Links
    NCBI Gene ID: 7220
    neXtProt AC: NX_P48995
    UniProt: P48995

  • Chr Location
    3q23; chr3:142724032-142807888 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased body weight and a severe loss of salivary gland fluid secretion due to attenuation of store-operated Ca2+ currents. Surprisingly, no abnormalities are seen in store-operated or mechanosensitive cation channels in vascular smooth muscle cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000047293 VEGA Gene Model | MGI Sequence Detail 45294 C57BL/6J ±  kb
    transcript OTTMUST00000122275 VEGA | MGI Sequence Detail 4559 Not Applicable  
    polypeptide OTTMUSP00000067131 VEGA | MGI Sequence Detail 809 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      601 from dbSNP Build 142
    • PCR
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • InterPro Domains
      IPR002110 Ankyrin repeat
      IPR020683 Ankyrin repeat-containing domain
      IPR036770 Ankyrin repeat-containing domain superfamily
      IPR005821 Ion transport domain
      IPR013555 Transient receptor ion channel domain
      IPR004729 Transient receptor potential channel
      IPR002153 Transient receptor potential channel, canonical
      IPR005457 Transient receptor potential channel, canonical 1
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 2
      cDNA 14
      Primer pair 4

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-39527
    References
    more
    • Summaries
      All 92
      Developmental Gene Expression 6
      Gene Ontology 10
      Phenotypes 32
    • Earliest
      J:33403 Zhu X, et al., trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry. Cell. 1996 May 31;85(5):661-71
    • Latest
      J:255153 Krout D, et al., The TRPC1 Ca(2+)-permeable channel inhibits exercise-induced protection against high-fat diet-induced obesity and type II diabetes. J Biol Chem. 2017 Dec 15;292(50):20799-20807

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/10/2018
    MGI 6.12
    The Jackson Laboratory