Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TPH2
  • Mouse genes Tph2
  • Rat genes Tph2
  • Zfish genes tph2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tph2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004510	tryptophan 5-monooxygenase activity	Tph2	IDA		Mouse	PMID:12511643
Cellular Component	GO:0043005	neuron projection	Tph2	IDA		Mouse	PMID:19906978
Biological Process	GO:0071285	cellular response to lithium ion	Tph2	IEP		Rat	PMID:19840776|RGD:2317083
Biological Process	GO:0007623	circadian rhythm	Tph2	IEP		Rat	PMID:15194882|RGD:2317079
Biological Process	GO:1902036	regulation of hematopoietic stem cell differentiation	tph2	IMP	ZFIN:ZDB-MRPHLNO-170908-4	Zfish	PMID:27424782
Biological Process	GO:1902036	regulation of hematopoietic stem cell differentiation	tph2	IGI	ZFIN:ZDB-GENE-030317-1,ZFIN:ZDB-GENE-030805-6	Zfish	PMID:27424782
Biological Process	GO:0014823	response to activity	Tph2	IEP		Rat	PMID:17595225|RGD:2317080
Biological Process	GO:0051592	response to calcium ion	Tph2	IEP		Rat	PMID:17868301|RGD:2317090
Biological Process	GO:0043627	response to estrogen	Tph2	IEP		Rat	PMID:16458260|RGD:2317086
Biological Process	GO:0051384	response to glucocorticoid	Tph2	IEP		Rat	PMID:17595225|RGD:2317080
Biological Process	GO:0031667	response to nutrient levels	Tph2	IEP		Rat	PMID:18986658|RGD:2317089

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern