Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TPCN1
  • Mouse genes Tpcn1
  • Rat genes Tpcn1
  • Zfish genes tpcn1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tpcn1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	TPCN1	IPI	UniProtKB:Q9ULQ1	Human	PMID:21903581
Molecular Function	GO:0097682	intracellular phosphatidylinositol-3,5-bisphosphate-sensitive monatomic cation channel activity	TPCN1	IDA		Human	PMID:23063126
Molecular Function	GO:0097682	intracellular phosphatidylinositol-3,5-bisphosphate-sensitive monatomic cation channel activity	TPCN1	IDA		Human	PMID:24776928
Molecular Function	GO:0097682	intracellular phosphatidylinositol-3,5-bisphosphate-sensitive monatomic cation channel activity	Tpcn1	IDA		Mouse	MGI:MGI:6718238|PMID:24776928
Molecular Function	GO:0015280	ligand-gated sodium channel activity	TPCN1	IDA		Human	PMID:23063126
Molecular Function	GO:0015280	ligand-gated sodium channel activity	TPCN1	IDA		Human	PMID:24776928
Molecular Function	GO:0015280	ligand-gated sodium channel activity	Tpcn1	IDA		Mouse	MGI:MGI:6718238|PMID:24776928
Molecular Function	GO:0015280	ligand-gated sodium channel activity	Tpcn1	IDA		Mouse	MGI:MGI:6316576|PMID:29562233
Molecular Function	GO:0072345	NAADP-sensitive calcium-release channel activity	TPCN1	IDA		Human	PMID:19620632
Molecular Function	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	Tpcn1	IDA		Mouse	MGI:MGI:6316576|PMID:29562233
Molecular Function	GO:0005515	protein binding	TPCN1	IPI	UniProtKB:Q9H910	Human	PMID:15094197
Molecular Function	GO:0005515	protein binding	TPCN1	IPI	UniProtKB:Q8NHX9	Human	PMID:21903581
Molecular Function	GO:0005515	protein binding	TPCN1	IPI	UniProtKB:O00165	Human	PMID:24188827
Molecular Function	GO:0042803	protein homodimerization activity	Tpcn1	IDA		Mouse	MGI:MGI:6316576|PMID:29562233
Molecular Function	GO:0019905	syntaxin binding	Tpcn1	IPI	UniProtKB:O70439|UniProtKB:O88983|UniProtKB:Q9ER00	Mouse	MGI:MGI:6716967|PMID:28855648
Molecular Function	GO:0005248	voltage-gated sodium channel activity	TPCN1	IDA		Human	PMID:24776928
Molecular Function	GO:0005248	voltage-gated sodium channel activity	Tpcn1	IDA		Mouse	MGI:MGI:6316576|PMID:29562233
Molecular Function	GO:0005248	voltage-gated sodium channel activity	Tpcn1	IDA		Mouse	MGI:MGI:6718238|PMID:24776928
Cellular Component	GO:0031901	early endosome membrane	Tpcn1	IDA		Mouse	MGI:MGI:6716967|PMID:28855648
Cellular Component	GO:0036019	endolysosome	TPCN1	IDA		Human	PMID:24776928
Cellular Component	GO:0036019	endolysosome	Tpcn1	IDA		Mouse	MGI:MGI:6718238|PMID:24776928
Cellular Component	GO:0010008	endosome membrane	TPCN1	IDA		Human	PMID:19620632
Cellular Component	GO:0010008	endosome membrane	TPCN1	IDA		Human	PMID:23063126
Cellular Component	GO:0005765	lysosomal membrane	TPCN1	IDA		Human	PMID:19620632
Cellular Component	GO:0005765	lysosomal membrane	TPCN1	IDA		Human	PMID:23063126
Cellular Component	GO:0016020	membrane	Tpcn1	IDA		Mouse	MGI:MGI:6316576|PMID:29562233
Cellular Component	GO:0055038	recycling endosome membrane	Tpcn1	IDA		Mouse	MGI:MGI:6716967|PMID:28855648
Biological Process	GO:0075509	endocytosis involved in viral entry into host cell	TPCN1	IMP		Human	PMID:25722412
Biological Process	GO:0075509	endocytosis involved in viral entry into host cell	Tpcn1	IMP		Mouse	MGI:MGI:6716961|PMID:25722412
Biological Process	GO:0010508	positive regulation of autophagy	TPCN1	IDA		Human	PMID:22012985
Biological Process	GO:0035725	sodium ion transmembrane transport	Tpcn1	IDA		Mouse	MGI:MGI:6316576|PMID:29562233

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern