Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TOB1
  • Mouse genes Tob1
  • Rat genes Tob1
  • Zfish genes tob1a,tob1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tob1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	TOB1	IPI	UniProtKB:A5YKK6	Human	PMID:18377426
Molecular Function	GO:0005515	protein binding	TOB1	IPI	UniProtKB:O75175	Human	PMID:18377426
Molecular Function	GO:0005515	protein binding	TOB1	IPI	UniProtKB:Q13148	Human	PMID:18377426
Molecular Function	GO:0005515	protein binding	TOB1	IPI	UniProtKB:Q96LI5	Human	PMID:18377426
Molecular Function	GO:0005515	protein binding	TOB1	IPI	UniProtKB:Q9UIV1	Human	PMID:18377426
Molecular Function	GO:0005515	protein binding	TOB1	IPI	UniProtKB:Q9UIV1	Human	PMID:19276069
Molecular Function	GO:0005515	protein binding	TOB1	IPI	UniProtKB:P11940	Human	PMID:20595394
Molecular Function	GO:0005515	protein binding	TOB1	IPI	UniProtKB:Q9UIV1	Human	PMID:20595394
Molecular Function	GO:0005515	protein binding	TOB1	IPI	UniProtKB:Q17RY0	Human	PMID:21336257
Molecular Function	GO:0005515	protein binding	TOB1	IPI	UniProtKB:Q8NE35	Human	PMID:21336257
Molecular Function	GO:0005515	protein binding	TOB1	IPI	UniProtKB:Q9UIV1	Human	PMID:21336257
Molecular Function	GO:0005515	protein binding	TOB1	IPI	UniProtKB:A5YKK6	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	TOB1	IPI	UniProtKB:O75175	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	TOB1	IPI	UniProtKB:Q96LI5	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	TOB1	IPI	UniProtKB:Q9UIV1	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	TOB1	IPI	UniProtKB:Q9UIV1	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	TOB1	IPI	UniProtKB:P06396	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TOB1	IPI	UniProtKB:P22607	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TOB1	IPI	UniProtKB:Q13148	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	TOB1	IPI	UniProtKB:P11940	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	Tob1	IPI	UniProtKB:P57737	Mouse	MGI:MGI:4936782|PMID:21130766
Molecular Function	GO:0005515	protein binding	Tob1	IPI	PR:P97471	Mouse	PMID:11163184
Molecular Function	GO:0005515	protein binding	Tob1	IPI	PR:P70340	Mouse	PMID:11163184
Molecular Function	GO:0005515	protein binding	Tob1	IPI	PR:Q9JIW5	Mouse	PMID:11163184
Molecular Function	GO:0005515	protein binding	Tob1	IPI	PR:P97454	Mouse	PMID:11163184
Molecular Function	GO:0005515	protein binding	tob1a	IPI	RefSeq:NP_058049	Zfish	PMID:16890162
Molecular Function	GO:0005515	protein binding	tob1a	IPI	RefSeq:NP_001036125	Zfish	PMID:16890162
Molecular Function	GO:0005515	protein binding	tob1a	IPI	ZFIN:ZDB-GENE-030128-4	Zfish	PMID:16890162
Molecular Function	GO:0005515	protein binding	tob1a	IPI	RefSeq:NP_032565	Zfish	PMID:16890162
Molecular Function	GO:0005515	protein binding	tob1a	IPI	RefSeq:NP_032566	Zfish	PMID:16890162
Molecular Function	GO:0005515	protein binding	tob1a	IPI	ZFIN:ZDB-GENE-000509-3	Zfish	PMID:16890162
Molecular Function	GO:0005515	protein binding	tob1a	IPI	ZFIN:ZDB-GENE-040426-2575	Zfish	PMID:16890162
Molecular Function	GO:0005515	protein binding	tob1a	IPI	RefSeq:NP_032568	Zfish	PMID:16890162
Molecular Function	GO:0005515	protein binding	tob1a	IPI	RefSeq:NP_034884	Zfish	PMID:16890162
Molecular Function	GO:0030971	receptor tyrosine kinase binding	TOB1	IDA		Human	PMID:8632892
Molecular Function	GO:0046332	SMAD binding	Tob1	IDA		Mouse	PMID:11163184
Molecular Function	GO:0003714	transcription corepressor activity	Tob1	IDA		Mouse	PMID:11163184
Molecular Function	GO:0140416	transcription regulator inhibitor activity	tob1a	IMP	ZFIN:ZDB-MRPHLNO-071205-3	Zfish	PMID:16890162
Molecular Function	GO:0140416	transcription regulator inhibitor activity	tob1a	IGI	ZFIN:ZDB-GENE-040426-2575	Zfish	PMID:16890162
Cellular Component	GO:0030014	CCR4-NOT complex	TOB1	IDA		Human	PMID:21336257
Cellular Component	GO:0005737	cytoplasm	Tob1	IDA		Mouse	PMID:11163184
Cellular Component	GO:0005737	cytoplasm	tob1a	IDA		Zfish	PMID:16890162
Cellular Component	GO:0005634	nucleus	tob1a	IDA		Zfish	PMID:16890162
Biological Process	GO:0030509	BMP signaling pathway	tob1a	IDA		Zfish	PMID:16890162
Biological Process	GO:0009953	dorsal/ventral pattern formation	tob1a	IMP	ZFIN:ZDB-MRPHLNO-071205-3	Zfish	PMID:16890162
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	Tob1	IDA		Mouse	PMID:11163184
Biological Process	GO:0008285	negative regulation of cell population proliferation	TOB1	IDA		Human	PMID:19276069
Biological Process	GO:0008285	negative regulation of cell population proliferation	TOB1	IDA		Human	PMID:8632892
Biological Process	GO:0060212	negative regulation of nuclear-transcribed mRNA poly(A) tail shortening	TOB1	IDA		Human	PMID:18377426
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	Tob1	IMP	MGI:MGI:1933294	Mouse	PMID:11163184
Biological Process	GO:0017148	negative regulation of translation	TOB1	IDA		Human	PMID:23236473
Biological Process	GO:1900153	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	TOB1	IDA		Human	PMID:21336257
Biological Process	GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	TOB1	IDA		Human	PMID:21336257
Biological Process	GO:0060390	regulation of SMAD protein signal transduction	Tob1	IDA		Mouse	PMID:11163184

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern