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Tob1
Gene Detail
Symbol

Name
ID
Tob1
transducer of ErbB-2.1
MGI:1349721
Synonyms
Tob, Trob
Feature Type
protein coding gene
Genetic Map
Chromosome 11
58.90 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:94211454-94215495 bp, + strand
From VEGA annotation of GRCm38

  4042 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31334  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: Transducer of erbB-2
Gene Tree: Tob1

Human
homologs
Human Homolog TOB1, transducer of ERBB2, 1
NCBI Gene ID 10140
neXtProt AC  NX_P50616
Human Synonyms  APRO6, PIG49, TOB, TROB, TROB1
Human Chr (Location)  17q21; chr17:50862223-50867978 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(6) Targeted(6)
Genomic Mutations involving Tob1 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice are viable and exhibit increased bone mass due to increased osteoblast proliferation and differentiation.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Tob1 interacts with 228 markers (Mir15a, Mir16-2, Mir25, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process negative regulation of BMP signaling pathway, negative regulation of cell proliferation, ...
Component CCR4-NOT complex, cytoplasm, ...
Function protein binding, receptor tyrosine kinase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (11)    Tissues (11)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 11
cDNA source data(53)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(56) Genomic(3) cDNA(53)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000001711 (Evidence)
Ensembl Gene ModelENSMUSG00000037573 (Evidence)
Entrez Gene22057 (Evidence)
UniGene259673
DFCITC1577653
DoTSDT.489900
Consensus CDS ProjectCCDS25250.1
International Mouse Knockout Project StatusTob1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001711 VEGA Gene Model | MGI Sequence Detail 4042 C57BL/6J ±  kb
transcript OTTMUST00000003376 VEGA | MGI Sequence Detail 2288 Not Applicable 
polypeptide OTTMUSP00000001617 VEGA | MGI Sequence Detail 362 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(32 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002087 Anti-proliferative protein
InterPro IPR015676 Tob
Protein Ontology PR:000016525 protein Tob1
References
(Earliest) J:41178 Yoshida Y, et al., Cloning and characterization of the mouse tob gene. Gene. 1997 May 20;191(1):109-13
(Latest) J:168702 Watanabe M, et al., Coronin7 forms a novel E3 ubiquitin ligase complex to promote the degradation of the anti-proliferative protein Tob. FEBS Lett. 2011 Jan 3;585(1):65-70
All references(40)
Other
accession IDs
MGI:894690

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory