Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TNK2
  • Mouse genes Tnk2
  • Rat genes Tnk2
  • Zfish genes tnk2a,tnk2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tnk2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005154	epidermal growth factor receptor binding	TNK2	IDA		Human	PMID:20086093
Molecular Function	GO:0042802	identical protein binding	TNK2	IPI	UniProtKB:Q07912	Human	PMID:16472662
Molecular Function	GO:0042802	identical protein binding	TNK2	IPI	UniProtKB:Q07912	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TNK2	IPI	UniProtKB:P60953-2	Human	PMID:10360579
Molecular Function	GO:0005515	protein binding	TNK2	IPI	UniProtKB:Q6UVK1	Human	PMID:10587647
Molecular Function	GO:0005515	protein binding	TNK2	IPI	UniProtKB:P60953-2	Human	PMID:11157984
Molecular Function	GO:0005515	protein binding	TNK2	IPI	UniProtKB:P56945	Human	PMID:17038317
Molecular Function	GO:0005515	protein binding	TNK2	IPI	UniProtKB:Q00610	Human	PMID:19798056
Molecular Function	GO:0005515	protein binding	TNK2	IPI	UniProtKB:P31749	Human	PMID:20333297
Molecular Function	GO:0005515	protein binding	TNK2	IPI	UniProtKB:P08238	Human	PMID:22939624
Molecular Function	GO:0005515	protein binding	TNK2	IPI	UniProtKB:Q96PU5	Human	PMID:23686771
Molecular Function	GO:0005515	protein binding	TNK2	IPI	UniProtKB:O60880	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TNK2	IPI	UniProtKB:P07902	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TNK2	IPI	UniProtKB:P29972	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TNK2	IPI	UniProtKB:Q7Z3S9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TNK2	IPI	UniProtKB:Q9HC98	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TNK2	IPI	UniProtKB:Q00610	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	TNK2	IPI	UniProtKB:P08238	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	TNK2	IPI	UniProtKB:Q00610	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	Tnk2	IPI	UniProtKB:P31750	Mouse	MGI:MGI:4440773|PMID:20333297
Molecular Function	GO:0005515	protein binding	Tnk2	IPI	UniProtKB:P62993	Mouse	MGI:MGI:4947352|PMID:20086093
Molecular Function	GO:0005515	protein binding	Tnk2	IPI	UniProtKB:P46934|UniProtKB:Q96PU5	Mouse	MGI:MGI:4947352|PMID:20086093
Molecular Function	GO:0005515	protein binding	Tnk2	IPI	UniProtKB:P00533	Mouse	MGI:MGI:3719934|PMID:17182860
Molecular Function	GO:0005515	protein binding	Tnk2	IPI	UniProtKB:P16333-1|UniProtKB:Q99M51	Mouse	MGI:MGI:3652639|PMID:16777958
Molecular Function	GO:0005515	protein binding	Tnk2	IPI	PR:P60766	Mouse	PMID:16052498
Molecular Function	GO:0005515	protein binding	Tnk2	IPI	UniprotKB:P60766	Mouse	PMID:18838382
Molecular Function	GO:0004712	protein serine/threonine/tyrosine kinase activity	TNK2	IDA		Human	PMID:16257963
Molecular Function	GO:0004713	protein tyrosine kinase activity	TNK2	IDA		Human	PMID:18993068
Molecular Function	GO:0004713	protein tyrosine kinase activity	Tnk2	IDA		Rat	PMID:16052498|RGD:8554454
Molecular Function	GO:0031625	ubiquitin protein ligase binding	TNK2	IPI	UniProtKB:P46934	Human	PMID:23686771
Molecular Function	GO:0050699	WW domain binding	Tnk2	IPI	UniProtKB:P46934	Mouse	MGI:MGI:4947352|PMID:20086093
Cellular Component	GO:0030424	axon	Tnk2	IDA		Mouse	PMID:16052498
Cellular Component	GO:0005905	clathrin-coated pit	TNK2	IDA		Human	PMID:21169560
Cellular Component	GO:0030136	clathrin-coated vesicle	TNK2	IDA		Human	PMID:18262180
Cellular Component	GO:0097268	cytoophidium	TNK2	IDA		Human	PMID:25223282
Cellular Component	GO:0005737	cytoplasm	TNK2	IDA		Human	PMID:20979614
Cellular Component	GO:0030425	dendrite	Tnk2	IDA		Mouse	PMID:16052498
Cellular Component	GO:0005768	endosome	Tnk2	IDA		Mouse	MGI:MGI:3719934|PMID:17182860
Cellular Component	GO:0070436	Grb2-EGFR complex	TNK2	IDA		Human	PMID:20086093
Cellular Component	GO:0030426	growth cone	Tnk2	IDA		Mouse	PMID:16052498
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	TNK2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	TNK2	HDA		Human	PMID:19946888
Cellular Component	GO:0043025	neuronal cell body	Tnk2	IDA		Mouse	PMID:16052498
Cellular Component	GO:0005634	nucleus	TNK2	IDA		Human	PMID:20333297
Cellular Component	GO:0005634	nucleus	Tnk2	IDA		Mouse	MGI:MGI:4440773|PMID:20333297
Cellular Component	GO:0005886	plasma membrane	TNK2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	TNK2	IDA		Human	PMID:20333297
Cellular Component	GO:0005886	plasma membrane	TNK2	IDA		Human	PMID:20979614
Cellular Component	GO:0005886	plasma membrane	Tnk2	IDA		Mouse	MGI:MGI:4440773|PMID:20333297
Biological Process	GO:0016310	phosphorylation	TNK2	IDA		Human	PMID:20333297
Biological Process	GO:0016310	phosphorylation	TNK2	IDA		Human	PMID:20979614
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	TNK2	IDA		Human	PMID:10587647
Biological Process	GO:2000369	regulation of clathrin-dependent endocytosis	TNK2	IDA		Human	PMID:18262180
Biological Process	GO:0007286	spermatid development	Tnk2	IGI	UniProtKB:Q8MRP0	Mouse	MGI:MGI:6246359|PMID:23562806

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern