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Tnk2 Gene Detail
Summary
  • Symbol
    Tnk2
  • Name
    tyrosine kinase, non-receptor, 2
  • Synonyms
    Ack, ACK1, activated p21cdc42Hs kinase, P21cdc42Hs kinase, Pyk1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858308
    NCBI Gene: 51789
  • Gene Overview
    MyGene.info: TNK2
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:32644099-32683493 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 23.16 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    191 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858308
protein coding gene Chr16:32643874-32683493 (.)
129S1/SvImJ MGP_129S1SvImJ_G0022743
protein coding gene Chr16:30738837-30784671 (+)
A/J MGP_AJ_G0022708
protein coding gene Chr16:29272937-29313466 (+)
AKR/J MGP_AKRJ_G0022681
protein coding gene Chr16:30336281-30379694 (+)
BALB/cJ MGP_BALBcJ_G0022710
protein coding gene Chr16:29420115-29460260 (+)
C3H/HeJ MGP_C3HHeJ_G0022475
protein coding gene Chr16:30461744-30501205 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023159
protein coding gene Chr16:31394134-31438205 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020677
protein coding gene Chr16:29650624-29690446 (+)
CAST/EiJ MGP_CASTEiJ_G0022003
protein coding gene Chr16:30602032-30643576 (+)
CBA/J MGP_CBAJ_G0022445
protein coding gene Chr16:32648024-32691707 (+)
DBA/2J MGP_DBA2J_G0022578
protein coding gene Chr16:29119479-29159910 (+)
FVB/NJ MGP_FVBNJ_G0022553
protein coding gene Chr16:29106056-29146512 (+)
LP/J MGP_LPJ_G0022645
protein coding gene Chr16:30489013-30532016 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022572
protein coding gene Chr16:32065551-32110204 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023171
protein coding gene Chr16:30315966-30358011 (+)
PWK/PhJ MGP_PWKPhJ_G0021742
protein coding gene Chr16:29448058-29488425 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021573
protein coding gene Chr16:30114200-30158395 (+)
WSB/EiJ MGP_WSBEiJ_G0022047
protein coding gene Chr16:30273073-30316783 (+)



Homology
more
  • Human Ortholog
    TNK2, tyrosine kinase non receptor 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TNK2, tyrosine kinase non receptor 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ACK, ACK1, ACK-1, p21cdc42Hs
  • Links
    NCBI Gene ID: 10188
    neXtProt AC: NX_Q07912
    UniProt: Q07912

  • Chr Location
    3q29; chr3:195863364-195909009 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 4224
    1 human;1 mouse;1 rat;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TNK2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 51789 NCBI Gene Model | MGI Sequence Detail 39395 C57BL/6J ±  kb
transcript NM_016788 RefSeq | MGI Sequence Detail 4454 C57BL/6  
polypeptide O54967 UniProt | EBI | MGI Sequence Detail 1055 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 111
    Genomic 1
    cDNA 110

    Microarray probesets 4
Other
Accession IDs
less
MGI:2146660
References
more
  • Summaries
    All 44
    Developmental Gene Expression 5
    Gene Ontology 12
    Phenotypes 7
  • Earliest
    J:44192 Gertler FB, et al., Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics. Cell. 1996 Oct 18;87(2):227-39
  • Latest
    J:187530 Mahajan K, et al., Ack1-mediated androgen receptor phosphorylation modulates radiation resistance in castration-resistant prostate cancer. J Biol Chem. 2012 Jun 22;287(26):22112-22

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory