Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TMPRSS2
  • Mouse genes Tmprss2
  • Rat genes Tmprss2
  • Zfish genes tmprss2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tmprss2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0140677	molecular function activator activity	TMPRSS2	IDA		Human	PMID:25122198
Molecular Function	GO:0005515	protein binding	TMPRSS2	IPI	UniProtKB:Q9BYF1	Human	PMID:21068237
Molecular Function	GO:0005515	protein binding	TMPRSS2	IPI	UniProtKB:P01009	Human	PMID:33741941
Molecular Function	GO:0004252	serine-type endopeptidase activity	TMPRSS2	IDA		Human	PMID:25122198
Cellular Component	GO:0070062	extracellular exosome	TMPRSS2	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	TMPRSS2	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	TMPRSS2	HDA		Human	PMID:23533145
Cellular Component	GO:0005654	nucleoplasm	TMPRSS2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	TMPRSS2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	TMPRSS2	IDA		Human	PMID:21068237
Biological Process	GO:0046598	positive regulation of viral entry into host cell	TMPRSS2	IDA		Human	PMID:21068237
Biological Process	GO:0046598	positive regulation of viral entry into host cell	TMPRSS2	IDA		Human	PMID:24227843
Biological Process	GO:0046598	positive regulation of viral entry into host cell	TMPRSS2	IDA		Human	PMID:32404436
Biological Process	GO:0016540	protein autoprocessing	TMPRSS2	IMP		Human	PMID:21068237
Biological Process	GO:0006508	proteolysis	TMPRSS2	IDA		Human	PMID:21068237
Biological Process	GO:0006508	proteolysis	TMPRSS2	IDA		Human	PMID:24227843
Biological Process	GO:0006508	proteolysis	Tmprss2	IDA		Mouse	MGI:MGI:5559607|PMID:24227843

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern