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Tmprss2 Gene Detail
Summary
  • Symbol
    Tmprss2
  • Name
    transmembrane protease, serine 2
  • Synonyms
    D16Ertd61e, epitheliasin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354381
    NCBI Gene: 50528
  • Gene Overview
    MyGene.info: TMPRSS2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr16:97564684-97611195 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      46512 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 57.53 cM, cytoband C2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    TMPRSS2, transmembrane serine protease 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TMPRSS2, transmembrane serine protease 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PP9284, PRSS10
  • Links
    NCBI Gene ID: 7113
    neXtProt AC: NX_O15393
    UniProt: O15393

  • Chr Location
    21q22.3; chr21:41464551-41508158 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 4 alleles in 3 genetic backgrounds
    10 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a disruption in this gene appear normal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000385 Ensembl Gene Model | MGI Sequence Detail 46512 C57BL/6J ±  kb
    transcript ENSMUST00000000395 Ensembl | MGI Sequence Detail 3159 Not Applicable  
    polypeptide ENSMUSP00000000395 Ensembl | MGI Sequence Detail 490 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      543 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 178
      Genomic 1
      cDNA 166
      Primer pair 10
      Other 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1098555
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 13
      Gene Ontology 4
      Phenotypes 21
    • Earliest
      J:60563 Jacquinet E, et al., Cloning, genomic organization, chromosomal assignment and expression of a novel mosaic serine proteinase: epitheliasin. FEBS Lett. 2000 Feb 18;468(1):93-100
    • Latest
      J:246218 Earnest JT, et al., The tetraspanin CD9 facilitates MERS-coronavirus entry by scaffolding host cell receptors and proteases. PLoS Pathog. 2017 Jul;13(7):e1006546

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory