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Tmprss2 Gene Detail
Summary
  • Symbol
    Tmprss2
  • Name
    transmembrane protease, serine 2
  • Synonyms
    D16Ertd61e, epitheliasin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354381
    NCBI Gene: 50528
  • Gene Overview
    MyGene.info: TMPRSS2
Location & Maps
more
  • Sequence Map
    Chr16:97564684-97611195 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      46512 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 57.53 cM, cytoband C2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    TMPRSS2, transmembrane protease, serine 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TMPRSS2, transmembrane protease, serine 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PP9284, PRSS10
  • Links
    NCBI Gene ID: 7113
    neXtProt AC: NX_O15393

  • Chr Location
    21q22.3; chr21:41464551-41508158 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 4 alleles in 3 genetic backgrounds
    10 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Targeted
    12
  • Genomic Mutations
    3 involving Tmprss2
  • Incidental Mutations
Mice homozygous for a disruption in this gene appear normal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000000385 Ensembl Gene Model | MGI Sequence Detail 46512 C57BL/6J ±  kb
transcript ENSMUST00000000395 Ensembl | MGI Sequence Detail 3159 Not Applicable  
polypeptide ENSMUSP00000000395 Ensembl | MGI Sequence Detail 490 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    543 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000016456 transmembrane protease serine 2
  • EC
  • InterPro Domains
    IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
    IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
    IPR001314 Peptidase S1A, chymotrypsin family
    IPR009003 Peptidase S1, PA clan
    IPR001254 Serine proteases, trypsin domain
    IPR018114 Serine proteases, trypsin family, histidine active site
    IPR033116 Serine proteases, trypsin family, serine active site
    IPR001190 SRCR domain
    IPR017448 SRCR-like domain
Molecular
Reagents
less
  • All nucleic 177
    Genomic 1
    cDNA 165
    Primer pair 10
    Other 1

    Microarray probesets 8
Other
Accession IDs
less
MGI:1098555
References
more
  • Summaries
    All 50
    Developmental Gene Expression 12
    Gene Ontology 4
    Phenotypes 15
  • Earliest
    J:60563 Jacquinet E, et al., Cloning, genomic organization, chromosomal assignment and expression of a novel mosaic serine proteinase: epitheliasin. FEBS Lett. 2000 Feb 18;468(1):93-100
  • Latest
    J:234426 Kuhn N, et al., The Proteolytic Activation of (H3N2) Influenza A Virus Hemagglutinin Is Facilitated by Different Type II Transmembrane Serine Proteases. J Virol. 2016 May;90(9):4298-307

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory