Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TMEM59
  • Mouse genes Tmem59
  • Rat genes Tmem59
  • Zfish genes tmem59
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tmem59

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004175	endopeptidase activity	Tmem59	IDA		Mouse	PMID:15574878
Molecular Function	GO:0005515	protein binding	TMEM59	IPI	UniProtKB:Q676U5	Human	PMID:23376921
Cellular Component	GO:0070062	extracellular exosome	TMEM59	HDA		Human	PMID:19056867
Cellular Component	GO:0000137	Golgi cis cisterna	TMEM59	IDA		Human	PMID:20427278
Cellular Component	GO:0005797	Golgi medial cisterna	TMEM59	IDA		Human	PMID:20427278
Cellular Component	GO:0000138	Golgi trans cisterna	TMEM59	IDA		Human	PMID:20427278
Cellular Component	GO:0005770	late endosome	TMEM59	IDA		Human	PMID:23376921
Cellular Component	GO:0005764	lysosome	TMEM59	IDA		Human	PMID:23376921
Biological Process	GO:1903077	negative regulation of protein localization to plasma membrane	TMEM59	IDA		Human	PMID:20427278
Biological Process	GO:0010508	positive regulation of autophagy	TMEM59	IMP		Human	PMID:23376921
Biological Process	GO:0006486	protein glycosylation	TMEM59	IDA		Human	PMID:20427278

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern