Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TMEM175
  • Mouse genes Tmem175
  • Rat genes Tmem175
  • Zfish genes tmem175
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tmem175

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0050544	arachidonic acid binding	TMEM175	IDA		Human	PMID:35750034
Molecular Function	GO:0005267	potassium channel activity	TMEM175	IDA		Human	PMID:28723891
Molecular Function	GO:0022841	potassium ion leak channel activity	TMEM175	IDA		Human	PMID:26317472
Molecular Function	GO:0022841	potassium ion leak channel activity	TMEM175	IDA		Human	PMID:32228865
Molecular Function	GO:0022841	potassium ion leak channel activity	Tmem175	IMP		Mouse	MGI:MGI:5693670|PMID:26317472
Molecular Function	GO:0005515	protein binding	TMEM175	IPI	UniProtKB:P31749	Human	PMID:33505021
Molecular Function	GO:0015252	proton channel activity	TMEM175	IDA		Human	PMID:35333573
Molecular Function	GO:0015252	proton channel activity	TMEM175	IDA		Human	PMID:35750034
Cellular Component	GO:0005768	endosome	TMEM175	IDA		Human	PMID:26317472
Cellular Component	GO:0010008	endosome membrane	TMEM175	IDA		Human	PMID:32228865
Cellular Component	GO:0005765	lysosomal membrane	TMEM175	IDA		Human	PMID:35750034
Cellular Component	GO:0005765	lysosomal membrane	TMEM175	HDA		Human	PMID:17897319
Cellular Component	GO:0005765	lysosomal membrane	TMEM175	IDA		Human	PMID:32228865
Cellular Component	GO:0005764	lysosome	TMEM175	IDA		Human	PMID:26317472
Cellular Component	GO:0005764	lysosome	TMEM175	IDA		Human	PMID:31261387
Cellular Component	GO:0005764	lysosome	TMEM175	IDA		Human	PMID:31658403
Biological Process	GO:0035752	lysosomal lumen pH elevation	TMEM175	IDA		Human	PMID:35333573
Biological Process	GO:0035752	lysosomal lumen pH elevation	TMEM175	IDA		Human	PMID:35750034
Biological Process	GO:0070050	neuron cellular homeostasis	Tmem175	IMP		Mouse	MGI:MGI:6694343|PMID:33505021
Biological Process	GO:0090385	phagosome-lysosome fusion	Tmem175	IMP		Mouse	MGI:MGI:5693670|PMID:26317472
Biological Process	GO:0071805	potassium ion transmembrane transport	TMEM175	IDA		Human	PMID:26317472
Biological Process	GO:0071805	potassium ion transmembrane transport	TMEM175	IDA		Human	PMID:28723891
Biological Process	GO:0071805	potassium ion transmembrane transport	TMEM175	IDA		Human	PMID:32228865
Biological Process	GO:0071805	potassium ion transmembrane transport	Tmem175	IMP		Mouse	MGI:MGI:5693670|PMID:26317472
Biological Process	GO:1902600	proton transmembrane transport	TMEM175	IDA		Human	PMID:35333573
Biological Process	GO:1902600	proton transmembrane transport	TMEM175	IDA		Human	PMID:35750034
Biological Process	GO:0035751	regulation of lysosomal lumen pH	TMEM175	IDA		Human	PMID:35750034
Biological Process	GO:0035751	regulation of lysosomal lumen pH	Tmem175	IMP		Mouse	MGI:MGI:5693670|PMID:26317472

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern