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Tmem175 Gene Detail
Summary
  • Symbol
    Tmem175
  • Name
    transmembrane protein 175
  • Synonyms
    3010001K23Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919642
    NCBI Gene: 72392
Location & Maps
more
  • Sequence Map
    Chr5:108629770-108648782 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      19013 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 53.24 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TMEM175, transmembrane protein 175
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TMEM175, transmembrane protein 175
    Orthology source: HGNC, HomoloGene
  • Synonyms
    hTMEM175
  • Links
    NCBI Gene ID: 84286
    neXtProt AC: NX_Q9BSA9

  • Chr Location
    4p16.3; chr4:932387-958656 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotype references
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    1
  • Gene trapped
    6
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Tmem175
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026815 VEGA Gene Model | MGI Sequence Detail 19013 C57BL/6J ±  kb
transcript OTTMUST00000066315 VEGA | MGI Sequence Detail 3956 Not Applicable  
polypeptide OTTMUSP00000033218 VEGA | MGI Sequence Detail 499 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    123 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000029801 endosomal/lysomomal potassium channel TMEM175
  • InterPro Domains
    IPR010617 Endosomal/lysomomal potassium channel TMEM175
Molecular
Reagents
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  • All nucleic 12
    cDNA 12

    Microarray probesets 5
Other
Accession IDs
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MGI:2140925
References
more
  • Summaries
    All 26
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:225577 Cang C, et al., TMEM175 Is an Organelle K(+) Channel Regulating Lysosomal Function. Cell. 2015 Aug 27;162(5):1101-12

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory