Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TMCO1
  • Mouse genes Tmco1
  • Rat genes Tmco1
  • Zfish genes tmco1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tmco1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005262	calcium channel activity	TMCO1	IDA		Human	PMID:27212239
Molecular Function	GO:0005515	protein binding	TMCO1	IPI	UniProtKB:P60059,UniProtKB:P60468,UniProtKB:P61619,UniProtKB:P69849,UniProtKB:Q15155,UniProtKB:Q5JPE7,UniProtKB:Q969V3,UniProtKB:Q96A33,UniProtKB:Q9BVK8	Human	PMID:32820719
Molecular Function	GO:0043022	ribosome binding	TMCO1	IDA		Human	PMID:32820719
Cellular Component	GO:0005783	endoplasmic reticulum	TMCO1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005789	endoplasmic reticulum membrane	TMCO1	IDA		Human	PMID:27212239
Cellular Component	GO:0160064	multi-pass translocon complex	TMCO1	IDA		Human	PMID:36261522
Biological Process	GO:0070588	calcium ion transmembrane transport	TMCO1	IDA		Human	PMID:27212239
Biological Process	GO:0070588	calcium ion transmembrane transport	Tmco1	IMP		Mouse	MGI:MGI:5787843|PMID:27212239
Biological Process	GO:0070588	calcium ion transmembrane transport	tmco1	IDA		Zfish	PMID:27212239|ZFIN:ZDB-PUB-170525-10
Biological Process	GO:0032469	endoplasmic reticulum calcium ion homeostasis	TMCO1	IDA		Human	PMID:27212239
Biological Process	GO:0032469	endoplasmic reticulum calcium ion homeostasis	Tmco1	IMP		Mouse	MGI:MGI:5787843|PMID:27212239
Biological Process	GO:0032469	endoplasmic reticulum calcium ion homeostasis	tmco1	IDA		Zfish	PMID:27212239|ZFIN:ZDB-PUB-170525-10
Biological Process	GO:0006983	ER overload response	TMCO1	IDA		Human	PMID:27212239
Biological Process	GO:0160063	multi-pass transmembrane protein insertion into ER membrane	TMCO1	IDA		Human	PMID:36261522

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern