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Tmco1
Gene Detail
 Symbol
Name
ID
Tmco1
transmembrane and coiled-coil domains 1
MGI:1921173
Synonyms 1190006A08Rik, 4930403O06Rik, ESTM39
Feature Type protein coding gene
Genetic Map
Chromosome 1
74.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:167308670-167333978 bp, + strand
From NCBI annotation of GRCm38

  25309 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10384  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transmembrane protein
Gene Tree: Tmco1

Human
homologs
Human Homolog TMCO1, transmembrane and coiled-coil domains 1
NCBI Gene ID 54499
neXtProt AC  NX_Q9UM00
Human Synonyms  HP10122, PCIA3, PNAS-136, TMCC4
Human Chr (Location)  1q22-q25; chr1:165724291-165768922 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human TMCO1
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(13)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Tmco1 interacts with 343 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process biological_process
Component endoplasmic reticulum, Golgi apparatus, ...
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (44)    Tissues (4)    Images (20)
Theiler Stages: 23
Assay TypeResults
RNA in situ 44
cDNA source data(109)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(110) cDNA(109) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000052428 (Evidence)
Entrez Gene68944 (Evidence)
UniGene330045
DFCITC1572717, TC1653388, TC1745395
DoTSDT.101130225, DT.101130228, DT.101152498, DT.494633
NIA Mouse Gene IndexU001055
Consensus CDS ProjectCCDS15456.1
International Mouse Knockout Project StatusTmco1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 68944 NCBI Gene Model | MGI Sequence Detail 25309 C57BL/6J ±  kb
transcript NM_001039483 RefSeq | MGI Sequence Detail 4474 C57BL/6 
polypeptide Q921L3 UniProt | EBI | MGI Sequence Detail 188 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(3) UniProt(2)
Polymorphisms SNPs within 2kb(125 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002809 Protein of unknown function DUF106, transmembrane
InterPro IPR008559 Uncharacterised conserved protein UCP023322, transmembrane eukaryotic
Protein Ontology PR:000029813 transmembrane and coiled-coil domain-containing protein 1
Graphical View of Protein Domain Structure
References (Earliest) J:52606 Eddleston J, et al., Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp). Genomics. 1999 Mar 1;56(2):149-59
(Latest) J:181586 Hald J, et al., Pancreatic islet and progenitor cell surface markers with cell sorting potential. Diabetologia. 2012 Jan;55(1):154-65
All references(37)
Other
accession IDs
MGI:1334461, MGI:1916194, MGI:2138472

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory