Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TJP2
  • Mouse genes Tjp2
  • Rat genes Tjp2
  • Zfish genes tjp2a,tjp2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tjp2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0045296	cadherin binding	TJP2	HDA		Human	PMID:25468996
Molecular Function	GO:0005515	protein binding	TJP2	IPI	UniProtKB:Q14160	Human	PMID:15975580
Molecular Function	GO:0005515	protein binding	TJP2	IPI	UniProtKB:Q9NPG3	Human	PMID:18823282
Molecular Function	GO:0005515	protein binding	TJP2	IPI	UniProtKB:Q14847	Human	PMID:22665060
Molecular Function	GO:0005515	protein binding	TJP2	IPI	UniProtKB:P55196	Human	PMID:23885123
Molecular Function	GO:0005515	protein binding	TJP2	IPI	UniProtKB:Q07157	Human	PMID:23885123
Molecular Function	GO:0005515	protein binding	Tjp2	IPI	UniProtKB:O35054|UniProtKB:O54942|UniProtKB:O88551|UniProtKB:O88552|UniProtKB:Q9Z0G9|UniProtKB:Q9Z260|UniProtKB:Q9Z261|UniProtKB:Q9Z262	Mouse	MGI:MGI:1350677|PMID:10601346
Molecular Function	GO:0005515	protein binding	Tjp2	IPI	PR:P56857	Mouse	PMID:22437732
Molecular Function	GO:0005515	protein binding	Tjp2	IPI	PR:O54851	Mouse	PMID:16650609
Molecular Function	GO:0005515	protein binding	Tjp2	IPI	PR:P15975	Mouse	PMID:26609154
Molecular Function	GO:0019904	protein domain specific binding	TJP2	IPI	UniProtKB:Q9Y624	Human	PMID:23885123
Molecular Function	GO:1990782	protein tyrosine kinase binding	TJP2	IPI	UniProtKB:P23458	Human	PMID:21679692
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	TJP2	IDA		Human	PMID:23885123
Molecular Function	GO:0044325	transmembrane transporter binding	Tjp2	IPI	RGD:2690	Rat	PMID:15980428|RGD:1582683
Cellular Component	GO:0005923	bicellular tight junction	TJP2	IDA		Human	PMID:22006950
Cellular Component	GO:0005923	bicellular tight junction	TJP2	IDA		Human	PMID:23885123
Cellular Component	GO:0005923	bicellular tight junction	Tjp2	IDA		Rat	PMID:10559001|RGD:631940
Cellular Component	GO:0030054	cell junction	Tjp2	IDA		Mouse	PMID:12507281
Cellular Component	GO:0044291	cell-cell contact zone	TJP2	IDA		Human	PMID:21679692
Cellular Component	GO:0005911	cell-cell junction	Tjp2	IDA		Mouse	MGI:MGI:6368095|PMID:25486565
Cellular Component	GO:0005911	cell-cell junction	Tjp2	IDA		Mouse	PMID:26609154
Cellular Component	GO:0005634	nucleus	TJP2	IDA		Human	PMID:20868367
Cellular Component	GO:0005634	nucleus	Tjp2	IDA		Mouse	MGI:MGI:6368095|PMID:25486565
Cellular Component	GO:0005634	nucleus	Tjp2	IDA		Mouse	PMID:22437732
Cellular Component	GO:0005886	plasma membrane	TJP2	IDA		Human	PMID:11090614
Cellular Component	GO:0005886	plasma membrane	Tjp2	IDA		Mouse	PMID:18423437
Cellular Component	GO:0005886	plasma membrane	Tjp2	IDA		Mouse	PMID:12060405
Cellular Component	GO:0005886	plasma membrane	Tjp2	IDA		Mouse	PMID:12507281
Cellular Component	GO:0070160	tight junction	Tjp2	IDA		Mouse	PMID:24889144
Cellular Component	GO:0070160	tight junction	Tjp2	IDA		Mouse	PMID:34166821
Biological Process	GO:0090557	establishment of endothelial intestinal barrier	TJP2	IMP		Human	PMID:23885123
Biological Process	GO:0034109	homotypic cell-cell adhesion	TJP2	IDA		Human	PMID:21679692
Biological Process	GO:0050892	intestinal absorption	TJP2	IMP		Human	PMID:23885123
Biological Process	GO:2001205	negative regulation of osteoclast development	Tjp2	IMP		Mouse	PMID:22437732
Biological Process	GO:1905605	positive regulation of blood-brain barrier permeability	TJP2	IMP		Human	PMID:19148554
Biological Process	GO:0090559	regulation of membrane permeability	TJP2	IMP		Human	PMID:23885123
Biological Process	GO:0010033	response to organic substance	Tjp2	IEP		Rat	PMID:15634758|RGD:1600164
Biological Process	GO:0071847	TNFSF11-mediated signaling pathway	Tjp2	IMP		Mouse	PMID:22437732

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern