Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TIRAP
  • Mouse genes Tirap
  • Rat genes Tirap
  • Zfish genes tirap
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tirap

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	TIRAP	IPI	UniProtKB:P58753	Human	PMID:17258210
Molecular Function	GO:0042802	identical protein binding	TIRAP	IPI	UniProtKB:P58753	Human	PMID:24275656
Molecular Function	GO:0042802	identical protein binding	Tirap	IPI	UniProtKB:Q99JY1	Mouse	MGI:MGI:2149909|PMID:11544529
Molecular Function	GO:0060090	molecular adaptor activity	TIRAP	IDA		Human	PMID:11544529
Molecular Function	GO:0060090	molecular adaptor activity	TIRAP	IDA		Human	PMID:16751103
Molecular Function	GO:0140677	molecular function activator activity	TIRAP	IDA		Human	PMID:11544529
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	Tirap	IDA		Mouse	MGI:MGI:4948831|PMID:16751103
Molecular Function	GO:0005515	protein binding	TIRAP	IPI	UniProtKB:O00206	Human	PMID:11544529
Molecular Function	GO:0005515	protein binding	TIRAP	IPI	UniProtKB:O43187	Human	PMID:11544529
Molecular Function	GO:0005515	protein binding	TIRAP	IPI	UniProtKB:Q99836	Human	PMID:11544529
Molecular Function	GO:0005515	protein binding	TIRAP	IPI	UniProtKB:O00206	Human	PMID:17258210
Molecular Function	GO:0005515	protein binding	TIRAP	IPI	UniProtKB:Q99836	Human	PMID:17258210
Molecular Function	GO:0005515	protein binding	TIRAP	IPI	UniProtKB:Q99836	Human	PMID:17583698
Molecular Function	GO:0005515	protein binding	TIRAP	IPI	UniProtKB:Q99836	Human	PMID:19509286
Molecular Function	GO:0005515	protein binding	TIRAP	IPI	UniProtKB:P27986	Human	PMID:19574958
Molecular Function	GO:0005515	protein binding	TIRAP	IPI	UniProtKB:Q99836	Human	PMID:19948740
Molecular Function	GO:0005515	protein binding	TIRAP	IPI	UniProtKB:Q99836	Human	PMID:21334391
Molecular Function	GO:0005515	protein binding	TIRAP	IPI	UniProtKB:O00206	Human	PMID:21829704
Molecular Function	GO:0005515	protein binding	TIRAP	IPI	UniProtKB:Q15109	Human	PMID:21829704
Molecular Function	GO:0005515	protein binding	TIRAP	IPI	UniProtKB:O00206	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	TIRAP	IPI	UniProtKB:O43187	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	TIRAP	IPI	UniProtKB:O94822	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	TIRAP	IPI	UniProtKB:P10398	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	TIRAP	IPI	UniProtKB:P51617	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	TIRAP	IPI	UniProtKB:Q96A33	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	TIRAP	IPI	UniProtKB:Q9NWZ3	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	TIRAP	IPI	UniProtKB:Q9Y3Z3	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	TIRAP	IPI	UniProtKB:Q8YF33	Human	PMID:22155231
Molecular Function	GO:0005515	protein binding	TIRAP	IPI	UniProtKB:Q8YF53	Human	PMID:24275656
Molecular Function	GO:0005515	protein binding	Tirap	IPI	UniProtKB:Q9EQ32	Mouse	MGI:MGI:5305503|PMID:22187460
Molecular Function	GO:0005515	protein binding	Tirap	IPI	UniProtKB:Q80UF7|UniProtKB:Q8BJQ4	Mouse	MGI:MGI:4942247|PMID:14517278
Molecular Function	GO:0005515	protein binding	Tirap	IPI	PR:P22366	Mouse	PMID:11544529
Molecular Function	GO:0005080	protein kinase C binding	TIRAP	IPI	UniProtKB:P09215	Human	PMID:17161867
Molecular Function	GO:0035663	Toll-like receptor 2 binding	TIRAP	IPI	UniProtKB:O60603	Human	PMID:19509286
Molecular Function	GO:0035663	Toll-like receptor 2 binding	Tirap	IPI	UniProtKB:Q9QUN7	Mouse	MGI:MGI:4943396|PMID:17322885
Molecular Function	GO:0035662	Toll-like receptor 4 binding	TIRAP	IPI	UniProtKB:O00206	Human	PMID:19509286
Cellular Component	GO:0009986	cell surface	TIRAP	IDA		Human	PMID:12447441
Cellular Component	GO:0005737	cytoplasm	TIRAP	IDA		Human	PMID:19948740
Cellular Component	GO:0030139	endocytic vesicle	Tirap	IDA		Mouse	MGI:MGI:4948831|PMID:16751103
Cellular Component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	TIRAP	IDA		Human	PMID:16751103
Cellular Component	GO:0005886	plasma membrane	TIRAP	IDA		Human	PMID:19948740
Cellular Component	GO:0032587	ruffle membrane	Tirap	IDA		Mouse	MGI:MGI:4948831|PMID:16751103
Biological Process	GO:0070935	3'-UTR-mediated mRNA stabilization	TIRAP	IDA		Human	PMID:15294994
Biological Process	GO:0007250	activation of NF-kappaB-inducing kinase activity	TIRAP	IMP		Human	PMID:24275656
Biological Process	GO:0007166	cell surface receptor signaling pathway	Tirap	IPI	UniProtKB:O00206	Mouse	PMID:11526399
Biological Process	GO:0071221	cellular response to bacterial lipopeptide	Tirap	IMP	MGI:MGI:3573942	Mouse	PMID:15690042
Biological Process	GO:0071223	cellular response to lipoteichoic acid	Tirap	IMP	MGI:MGI:3573942	Mouse	PMID:15690042
Biological Process	GO:0050830	defense response to Gram-positive bacterium	Tirap	IMP	MGI:MGI:3573942	Mouse	PMID:15690042
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	Tirap	IMP		Mouse	PMID:11526399
Biological Process	GO:0010934	macrophage cytokine production	Tirap	IMP	MGI:MGI:3573942	Mouse	PMID:15690042
Biological Process	GO:0030099	myeloid cell differentiation	Tirap	IMP		Mouse	PMID:11526399
Biological Process	GO:0030890	positive regulation of B cell proliferation	Tirap	IMP		Mouse	MGI:MGI:3531416|PMID:12447442
Biological Process	GO:2000340	positive regulation of chemokine (C-X-C motif) ligand 1 production	Tirap	IMP		Mouse	MGI:MGI:3713420|PMID:16301656
Biological Process	GO:2000343	positive regulation of chemokine (C-X-C motif) ligand 2 production	Tirap	IMP		Mouse	MGI:MGI:3713420|PMID:16301656
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	TIRAP	IMP		Human	PMID:11544529
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	TIRAP	IMP		Human	PMID:19509286
Biological Process	GO:0045089	positive regulation of innate immune response	Tirap	IMP		Mouse	MGI:MGI:3713420|PMID:16301656
Biological Process	GO:0032735	positive regulation of interleukin-12 production	Tirap	IMP		Mouse	MGI:MGI:3531416|PMID:12447442
Biological Process	GO:0032738	positive regulation of interleukin-15 production	TIRAP	IDA		Human	PMID:18583567
Biological Process	GO:0032755	positive regulation of interleukin-6 production	TIRAP	IMP		Human	PMID:16301656
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Tirap	IMP		Mouse	MGI:MGI:4943396|PMID:17322885
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Tirap	IMP		Mouse	MGI:MGI:3713420|PMID:16301656
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Tirap	IDA		Mouse	MGI:MGI:4942252|PMID:12421970
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Tirap	IMP		Mouse	MGI:MGI:3531416|PMID:12447442
Biological Process	GO:0032757	positive regulation of interleukin-8 production	TIRAP	IMP		Human	PMID:16301656
Biological Process	GO:0032757	positive regulation of interleukin-8 production	Tirap	IMP		Mouse	MGI:MGI:3713420|PMID:16301656
Biological Process	GO:0046330	positive regulation of JNK cascade	TIRAP	IMP		Human	PMID:11544529
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	Tirap	IMP	MGI:MGI:3573942	Mouse	PMID:15690042
Biological Process	GO:0090023	positive regulation of neutrophil chemotaxis	Tirap	IMP		Mouse	MGI:MGI:4943391|PMID:18039275
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	TIRAP	IMP		Human	PMID:19509286
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	Tirap	IMP		Mouse	MGI:MGI:3531416|PMID:12447442
Biological Process	GO:0031334	positive regulation of protein-containing complex assembly	TIRAP	IDA		Human	PMID:12062447
Biological Process	GO:0034137	positive regulation of toll-like receptor 2 signaling pathway	TIRAP	IMP		Human	PMID:19509286
Biological Process	GO:0034141	positive regulation of toll-like receptor 3 signaling pathway	Tirap	IDA		Mouse	MGI:MGI:4943396|PMID:17322885
Biological Process	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway	TIRAP	IMP		Human	PMID:19509286
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	TIRAP	IMP		Human	PMID:16301656
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	TIRAP	IMP		Human	PMID:19509286
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Tirap	IMP		Mouse	MGI:MGI:3713420|PMID:16301656
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Tirap	IMP		Mouse	MGI:MGI:3531416|PMID:12447442
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Tirap	IMP	MGI:MGI:3573942	Mouse	PMID:15690042
Biological Process	GO:0032648	regulation of interferon-beta production	Tirap	IDA		Mouse	MGI:MGI:4942245|PMID:14630816
Biological Process	GO:0032658	regulation of interleukin-15 production	Tirap	IMP		Mouse	MGI:MGI:4943383|PMID:18583567
Biological Process	GO:0032496	response to lipopolysaccharide	TIRAP	IDA		Human	PMID:11544529
Biological Process	GO:0035665	TIRAP-dependent toll-like receptor 4 signaling pathway	TIRAP	IDA		Human	PMID:11544529
Biological Process	GO:0034142	toll-like receptor 4 signaling pathway	TIRAP	IDA		Human	PMID:16751103
Biological Process	GO:0032640	tumor necrosis factor production	Tirap	IMP	MGI:MGI:3573942	Mouse	PMID:15690042

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern