Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TIGIT
  • Mouse genes Tigit
  • Rat genes Tigit
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tigit

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	TIGIT	IPI	UniProtKB:Q495A1	Human	PMID:27978489
Molecular Function	GO:0005515	protein binding	TIGIT	IPI	UniProtKB:P15151	Human	PMID:19011627
Molecular Function	GO:0005515	protein binding	TIGIT	IPI	UniProtKB:Q92692	Human	PMID:19011627
Molecular Function	GO:0005515	protein binding	TIGIT	IPI	UniProtKB:Q9NQS3	Human	PMID:19011627
Molecular Function	GO:0005515	protein binding	TIGIT	IPI	UniProtKB:P15151	Human	PMID:21982860
Molecular Function	GO:0005515	protein binding	TIGIT	IPI	UniProtKB:Q92692	Human	PMID:21982860
Molecular Function	GO:0005515	protein binding	TIGIT	IPI	UniProtKB:Q96NY8	Human	PMID:21982860
Molecular Function	GO:0005515	protein binding	TIGIT	IPI	UniProtKB:Q9NQS3	Human	PMID:21982860
Molecular Function	GO:0005515	protein binding	TIGIT	IPI	UniProtKB:Q15762	Human	PMID:25465800
Molecular Function	GO:0005515	protein binding	TIGIT	IPI	UniProtKB:Q92692	Human	PMID:27978489
Molecular Function	GO:0005515	protein binding	TIGIT	IPI	UniProtKB:P15151	Human	PMID:28515320
Molecular Function	GO:0005515	protein binding	TIGIT	IPI	UniProtKB:Q92692	Human	PMID:28515320
Molecular Function	GO:0005515	protein binding	TIGIT	IPI	UniProtKB:P21145	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TIGIT	IPI	UniProtKB:Q9Y342	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Tigit	IPI	UniProtKB:Q60977	Mouse	PMID:24658051
Molecular Function	GO:0005102	signaling receptor binding	TIGIT	IPI	UniProtKB:P15151	Human	PMID:19011627
Molecular Function	GO:0005102	signaling receptor binding	Tigit	IPI	UniProtKB:Q8K094	Mouse	PMID:21416464
Cellular Component	GO:0009986	cell surface	TIGIT	IDA		Human	PMID:19011627
Biological Process	GO:0032695	negative regulation of interleukin-12 production	TIGIT	IMP		Human	PMID:19011627
Biological Process	GO:0050868	negative regulation of T cell activation	TIGIT	IDA		Human	PMID:19011627
Biological Process	GO:0050868	negative regulation of T cell activation	TIGIT	IMP		Human	PMID:19011627
Biological Process	GO:0050868	negative regulation of T cell activation	Tigit	IMP	MGI:MGI:4939784	Mouse	PMID:21199897
Biological Process	GO:0032733	positive regulation of interleukin-10 production	TIGIT	IMP		Human	PMID:19011627

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern