Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TICAM2
  • Mouse genes Ticam2
  • Rat genes Ticam2
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ticam2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0060090	molecular adaptor activity	TICAM2	IDA		Human	PMID:28630139
Molecular Function	GO:0140677	molecular function activator activity	TICAM2	IDA		Human	PMID:28630139
Molecular Function	GO:0005543	phospholipid binding	Ticam2	IDA		Mouse	MGI:MGI:3778252|PMID:18297073
Molecular Function	GO:0005515	protein binding	TICAM2	IPI	UniProtKB:O00206	Human	PMID:17258210
Molecular Function	GO:0005515	protein binding	TICAM2	IPI	UniProtKB:Q6SZW1	Human	PMID:17258210
Molecular Function	GO:0005515	protein binding	TICAM2	IPI	UniProtKB:O00206	Human	PMID:21829704
Molecular Function	GO:0005515	protein binding	TICAM2	IPI	UniProtKB:O00206	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	TICAM2	IPI	UniProtKB:P50222	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TICAM2	IPI	UniProtKB:Q8IUC6	Human	PMID:25736436
Molecular Function	GO:0005515	protein binding	TICAM2	IPI	UniProtKB:Q6SZW1	Human	PMID:26592460
Molecular Function	GO:0005515	protein binding	TICAM2	IPI	UniProtKB:Q7L804	Human	PMID:30883606
Molecular Function	GO:0005515	protein binding	TICAM2	IPI	UniProtKB:Q96HA8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Ticam2	IPI	UniProtKB:Q99JY1	Mouse	MGI:MGI:4942247|PMID:14517278
Cellular Component	GO:0005768	endosome	TICAM2	IDA		Human	PMID:28630139
Cellular Component	GO:0005768	endosome	Ticam2	IDA		Mouse	MGI:MGI:3778252|PMID:18297073
Cellular Component	GO:0001891	phagocytic cup	TICAM2	IDA		Human	PMID:30883606
Cellular Component	GO:0005886	plasma membrane	Ticam2	IDA		Mouse	MGI:MGI:3778252|PMID:18297073
Biological Process	GO:0071222	cellular response to lipopolysaccharide	TICAM2	IMP		Human	PMID:22685567
Biological Process	GO:0051607	defense response to virus	Ticam2	IMP		Mouse	PMID:25268627
Biological Process	GO:0006909	phagocytosis	TICAM2	IMP		Human	PMID:30883606
Biological Process	GO:0006909	phagocytosis	Ticam2	IMP		Mouse	MGI:MGI:6294226|PMID:30883606
Biological Process	GO:0071651	positive regulation of chemokine (C-C motif) ligand 5 production	Ticam2	IDA		Mouse	MGI:MGI:3778252|PMID:18297073
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	TICAM2	HMP		Human	PMID:12761501
Biological Process	GO:2000494	positive regulation of interleukin-18-mediated signaling pathway	TICAM2	IMP		Human	PMID:22685567
Biological Process	GO:2000494	positive regulation of interleukin-18-mediated signaling pathway	Ticam2	IMP		Mouse	MGI:MGI:5488868|PMID:22685567
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Ticam2	IDA		Mouse	MGI:MGI:3778252|PMID:18297073
Biological Process	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway	TICAM2	IMP		Human	PMID:22685567
Biological Process	GO:0032481	positive regulation of type I interferon production	TICAM2	IDA		Human	PMID:25385819
Biological Process	GO:0032729	positive regulation of type II interferon production	Ticam2	IMP		Mouse	MGI:MGI:5488868|PMID:22685567
Biological Process	GO:0001817	regulation of cytokine production	Ticam2	IMP	MGI:MGI:3040182	Mouse	PMID:14556004
Biological Process	GO:0070671	response to interleukin-12	Ticam2	IMP		Mouse	MGI:MGI:5488868|PMID:22685567
Biological Process	GO:0035669	TRAM-dependent toll-like receptor 4 signaling pathway	TICAM2	IMP		Human	PMID:22685567

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern