Comparative GO Graph (mouse, human, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Ticam1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes TICAM1
- Mouse genes Ticam1
- Rat genes
- Zfish genes ticam1
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ticam1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0060090	molecular adaptor activity	TICAM1	IDA		Human	PMID:12471095
Molecular Function	GO:0005515	protein binding	TICAM1	IPI	UniProtKB:Q9Y4K3	Human	PMID:14982987
Molecular Function	GO:0005515	protein binding	TICAM1	IPI	UniProtKB:P21580	Human	PMID:15142865
Molecular Function	GO:0005515	protein binding	TICAM1	IPI	UniProtKB:Q9UHD2	Human	PMID:15841462
Molecular Function	GO:0005515	protein binding	TICAM1	IPI	UniProtKB:Q9UHD2	Human	PMID:19416887
Molecular Function	GO:0005515	protein binding	TICAM1	IPI	UniProtKB:Q9UHD2	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	TICAM1	IPI	UniProtKB:Q9BRZ2	Human	PMID:22948160
Molecular Function	GO:0005515	protein binding	TICAM1	IPI	UniProtKB:O15455	Human	PMID:25736436
Molecular Function	GO:0005515	protein binding	TICAM1	IPI	UniProtKB:Q13546	Human	PMID:25736436
Molecular Function	GO:0005515	protein binding	TICAM1	IPI	UniProtKB:Q86XR7	Human	PMID:25736436
Molecular Function	GO:0005515	protein binding	TICAM1	IPI	UniProtKB:Q9UHD2	Human	PMID:25736436
Molecular Function	GO:0005515	protein binding	TICAM1	IPI	UniProtKB:Q9Y4K3	Human	PMID:25736436
Molecular Function	GO:0005515	protein binding	Ticam1	IPI	UniProtKB:Q3TTA7	Mouse	MGI:MGI:4819286\|PMID:20639876
Molecular Function	GO:0005515	protein binding	Ticam1	IPI	UniProtKB:P35991\|UniProtKB:Q9WUN2	Mouse	MGI:MGI:5002402\|PMID:21441935
Molecular Function	GO:0005515	protein binding	Ticam1	IPI	UniProtKB:Q9WUN2	Mouse	MGI:MGI:5318897\|PMID:22454496
Molecular Function	GO:0005515	protein binding	Ticam1	IPI	UniProtKB:Q99JY1	Mouse	MGI:MGI:4942247\|PMID:14517278
Molecular Function	GO:0005515	protein binding	Ticam1	IPI	UniProtKB:Q60803	Mouse	MGI:MGI:4839450\|PMID:16306937
Molecular Function	GO:0005515	protein binding	Ticam1	IPI	UniProtKB:Q3UDK1	Mouse	MGI:MGI:3831253\|PMID:18849341
Molecular Function	GO:0005515	protein binding	Ticam1	IPI	UniProtKB:Q60803	Mouse	MGI:MGI:5918298\|PMID:16306936
Molecular Function	GO:0005515	protein binding	Ticam1	IPI	UniProtKB:Q9JIK5	Mouse	MGI:MGI:5050760\|PMID:21703541
Molecular Function	GO:0005515	protein binding	Ticam1	IPI	UniProtKB:E9Q4P1\|UniProtKB:Q99MB1	Mouse	MGI:MGI:5688815\|PMID:25736436
Molecular Function	GO:0005515	protein binding	Ticam1	IPI	UniProtKB:Q13546	Mouse	PMID:19734906
Molecular Function	GO:0005515	protein binding	ticam1	IPI	ZFIN:ZDB-GENE-070705-132	Zfish	PMID:17372010
Molecular Function	GO:0005515	protein binding	ticam1	IPI	UniProtKB:Q0GKD6	Zfish	PMID:17372010
Molecular Function	GO:0005515	protein binding	ticam1	IPI	UniProtKB:Q6IWL5	Zfish	PMID:17372010
Molecular Function	GO:0005515	protein binding	ticam1	IPI	ZFIN:ZDB-GENE-080303-3	Zfish	PMID:27206770
Molecular Function	GO:0019901	protein kinase binding	TICAM1	IPI	UniProtKB:Q9UHD2	Human	PMID:14530355
Molecular Function	GO:0097027	ubiquitin-protein transferase activator activity	TICAM1	IDA		Human	PMID:12471095
Cellular Component	GO:0005829	cytosol	Ticam1	IDA		Mouse	MGI:MGI:5050760\|PMID:21703541
Cellular Component	GO:0005769	early endosome	TICAM1	IDA		Human	PMID:17982077
Cellular Component	GO:0005768	endosome	TICAM1	IDA		Human	PMID:18222170
Cellular Component	GO:0005794	Golgi apparatus	ticam1	IDA		Zfish	PMID:18390719
Cellular Component	GO:0005739	mitochondrion	Ticam1	IDA		Mouse	MGI:MGI:5050760\|PMID:21703541
Cellular Component	GO:0097342	ripoptosome	TICAM1	IDA		Human	PMID:21737330
Biological Process	GO:0097190	apoptotic signaling pathway	Ticam1	IMP	MGI:MGI:2679794	Mouse	PMID:12872135
Biological Process	GO:0042113	B cell activation	Ticam1	IMP	MGI:MGI:3029019	Mouse	PMID:12855817
Biological Process	GO:0042100	B cell proliferation	Ticam1	IMP	MGI:MGI:3029019	Mouse	PMID:12855817
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Ticam1	IMP		Mouse	MGI:MGI:3718934\|PMID:17658277
Biological Process	GO:0140052	cellular response to oxidised low-density lipoprotein particle stimulus	Ticam1	IMP		Mouse	MGI:MGI:4438693\|PMID:20037584
Biological Process	GO:0032602	chemokine production	Ticam1	IMP	MGI:MGI:3029019	Mouse	PMID:12855817
Biological Process	GO:0032602	chemokine production	Ticam1	IGI	MGI:MGI:108005	Mouse	PMID:12855817
Biological Process	GO:0051607	defense response to virus	Ticam1	IMP	MGI:MGI:2679794	Mouse	PMID:12872135
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	Ticam1	IGI	MGI:MGI:108005	Mouse	PMID:12855817
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	Ticam1	IMP	MGI:MGI:3029019	Mouse	PMID:12855817
Biological Process	GO:0032608	interferon-beta production	Ticam1	IMP	MGI:MGI:3029019	Mouse	PMID:12855817
Biological Process	GO:0032608	interferon-beta production	Ticam1	IMP	MGI:MGI:2679794	Mouse	PMID:12872135
Biological Process	GO:0032635	interleukin-6 production	Ticam1	IMP	MGI:MGI:3029019	Mouse	PMID:12855817
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	Ticam1	IMP	MGI:MGI:2679794	Mouse	PMID:12872135
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	Ticam1	IMP	MGI:MGI:3029019	Mouse	PMID:12855817
Biological Process	GO:0002281	macrophage activation involved in immune response	Ticam1	IMP	MGI:MGI:2679794	Mouse	PMID:12872135
Biological Process	GO:0010934	macrophage cytokine production	Ticam1	IMP	MGI:MGI:3029019	Mouse	PMID:12855817
Biological Process	GO:0010934	macrophage cytokine production	Ticam1	IMP	MGI:MGI:2679794	Mouse	PMID:12872135
Biological Process	GO:0010934	macrophage cytokine production	Ticam1	IGI	MGI:MGI:108005	Mouse	PMID:12872135
Biological Process	GO:0010934	macrophage cytokine production	Ticam1	IDA		Mouse	PMID:12872135
Biological Process	GO:0002756	MyD88-independent toll-like receptor signaling pathway	Ticam1	IMP	MGI:MGI:2679794	Mouse	PMID:12872135
Biological Process	GO:0002756	MyD88-independent toll-like receptor signaling pathway	Ticam1	IMP	MGI:MGI:3029019	Mouse	PMID:12855817
Biological Process	GO:0006809	nitric oxide biosynthetic process	Ticam1	IMP	MGI:MGI:2679794	Mouse	PMID:12872135
Biological Process	GO:0010508	positive regulation of autophagy	Ticam1	IMP		Mouse	MGI:MGI:3718934\|PMID:17658277
Biological Process	GO:0050871	positive regulation of B cell activation	Ticam1	IMP	MGI:MGI:3029019	Mouse	PMID:12855817
Biological Process	GO:0030890	positive regulation of B cell proliferation	Ticam1	IMP	MGI:MGI:3029019	Mouse	PMID:12855817
Biological Process	GO:0032722	positive regulation of chemokine production	Ticam1	IMP	MGI:MGI:3029019	Mouse	PMID:12855817
Biological Process	GO:0032722	positive regulation of chemokine production	Ticam1	IGI	MGI:MGI:108005	Mouse	PMID:12855817
Biological Process	GO:1900017	positive regulation of cytokine production involved in inflammatory response	Ticam1	IMP		Mouse	MGI:MGI:4438693\|PMID:20037584
Biological Process	GO:0010628	positive regulation of gene expression	Ticam1	IMP		Mouse	MGI:MGI:4438693\|PMID:20037584
Biological Process	GO:0010628	positive regulation of gene expression	Ticam1	IGI	UniProtKB:P05067:PRO_0000000092	Mouse	MGI:MGI:4438693\|PMID:20037584
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	TICAM1	HMP		Human	PMID:12761501
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	TICAM1	IMP		Human	PMID:14982987
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	Ticam1	IMP		Mouse	MGI:MGI:5050760\|PMID:21703541
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	Ticam1	IMP	MGI:MGI:3029019	Mouse	PMID:12855817
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	Ticam1	IGI	MGI:MGI:108005	Mouse	PMID:12855817
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	ticam1	IDA		Zfish	PMID:18390719
Biological Process	GO:0032728	positive regulation of interferon-beta production	Ticam1	IMP	MGI:MGI:3029019	Mouse	PMID:12855817
Biological Process	GO:0032728	positive regulation of interferon-beta production	Ticam1	IMP	MGI:MGI:2679794	Mouse	PMID:12872135
Biological Process	GO:0032728	positive regulation of interferon-beta production	ticam1	IDA		Zfish	PMID:18390719
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Ticam1	IMP	MGI:MGI:3029019	Mouse	PMID:12855817
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	Ticam1	IGI	MGI:MGI:108005	Mouse	PMID:12872135
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	Ticam1	IMP	MGI:MGI:2679794	Mouse	PMID:12872135
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	Ticam1	IMP	MGI:MGI:3029019	Mouse	PMID:12855817
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	Ticam1	IDA		Mouse	PMID:12872135
Biological Process	GO:0002735	positive regulation of myeloid dendritic cell cytokine production	Ticam1	IMP		Mouse	MGI:MGI:5050760\|PMID:21703541
Biological Process	GO:0032816	positive regulation of natural killer cell activation	Ticam1	IMP	MGI:MGI:3701472	Mouse	PMID:21059856
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	Ticam1	IGI	MGI:MGI:108005	Mouse	PMID:12855817
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	Ticam1	IMP	MGI:MGI:3029019	Mouse	PMID:12855817
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	Ticam1	IMP	MGI:MGI:2679794	Mouse	PMID:12872135
Biological Process	GO:0032092	positive regulation of protein binding	Ticam1	IDA		Mouse	PMID:19734906
Biological Process	GO:0031398	positive regulation of protein ubiquitination	Ticam1	IDA		Mouse	PMID:19734906
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Ticam1	IMP	MGI:MGI:2679794	Mouse	PMID:12872135
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Ticam1	IGI	MGI:MGI:108005	Mouse	PMID:12872135
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Ticam1	IDA		Mouse	PMID:12872135
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Ticam1	IMP	MGI:MGI:3029019	Mouse	PMID:12855817
Biological Process	GO:0032481	positive regulation of type I interferon production	TICAM1	IDA		Human	PMID:28049150
Biological Process	GO:0032481	positive regulation of type I interferon production	Ticam1	IMP	MGI:MGI:2679794	Mouse	PMID:12872135
Biological Process	GO:0043254	regulation of protein-containing complex assembly	Ticam1	IMP	MGI:MGI:2679794	Mouse	PMID:12872135
Biological Process	GO:0043330	response to exogenous dsRNA	TICAM1	IMP		Human	PMID:21266579
Biological Process	GO:0043330	response to exogenous dsRNA	Ticam1	IMP	MGI:MGI:2679794	Mouse	PMID:12872135
Biological Process	GO:0043330	response to exogenous dsRNA	Ticam1	IMP	MGI:MGI:3029019	Mouse	PMID:12855817
Biological Process	GO:0043330	response to exogenous dsRNA	Ticam1	IDA		Mouse	PMID:12872135
Biological Process	GO:0043330	response to exogenous dsRNA	Ticam1	IMP		Mouse	PMID:21703541
Biological Process	GO:0032496	response to lipopolysaccharide	Ticam1	IMP	MGI:MGI:3029019	Mouse	PMID:12855817
Biological Process	GO:0032496	response to lipopolysaccharide	Ticam1	IMP	MGI:MGI:2679794	Mouse	PMID:12872135
Biological Process	GO:0032496	response to lipopolysaccharide	Ticam1	IGI	MGI:MGI:108005	Mouse	PMID:12872135
Biological Process	GO:0002224	toll-like receptor signaling pathway	TICAM1	IDA		Human	PMID:12471095
Biological Process	GO:0035666	TRIF-dependent toll-like receptor signaling pathway	TICAM1	IMP		Human	PMID:25636800
Biological Process	GO:0035666	TRIF-dependent toll-like receptor signaling pathway	Ticam1	IMP		Mouse	MGI:MGI:3718934\|PMID:17658277
Biological Process	GO:0032640	tumor necrosis factor production	Ticam1	IDA		Mouse	PMID:12872135
Biological Process	GO:0032640	tumor necrosis factor production	Ticam1	IMP	MGI:MGI:2679794	Mouse	PMID:12872135
Biological Process	GO:0032640	tumor necrosis factor production	Ticam1	IMP	MGI:MGI:3029019	Mouse	PMID:12855817
Biological Process	GO:0032640	tumor necrosis factor production	Ticam1	IGI	MGI:MGI:108005	Mouse	PMID:12872135
Biological Process	GO:0032606	type I interferon production	Ticam1	IMP	MGI:MGI:2679794	Mouse	PMID:12872135

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.