Ticam1
Gene Detail

Symbol Name ID

Ticam1 toll-like receptor adaptor molecule 1 MGI:2147032

Synonyms

TICAM-1, Trif

Feature Type

protein coding gene

Genetic Map

Chromosome 17

29.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr17:56269319-56276786 bp, - strand From VEGA annotation of GRCm38   7468 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:8605  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: toll-interleukin I receptor domain-containing adaptor protein, Ticam type
Gene Tree: Ticam1

Human homologs

Human Homolog		TICAM1, toll-like receptor adaptor molecule 1
NCBI Gene ID		148022
neXtProt AC		NX_Q8IUC6
Human Synonyms		IIAE6, MyD88-3, PRVTIRB, TICAM-1, TRIF
Human Chr (Location)		19p13.3; chr19:4815936-4831754 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TICAM1

Alleles and phenotypes

All alleles(11) : Targeted(6) Gene trapped(4) Chemically induced(1)
 

Homozygous null mice are viable but exhibit abnormalities of the innate immune system.

 

Gene Ontology (GO) classifications

All GO classifications: (46 annotations)

Process	apoptotic process, apoptotic signaling pathway, ...
Function	protein binding, protein kinase binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (24)    Tissues (15)    Images (2)
Theiler Stages: 23

Assay Type	Results
RNA in situ	24

cDNA source data(43)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(43) cDNA(43)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000016637 (Evidence)
Ensembl Gene Model	ENSMUSG00000047123 (Evidence)
Entrez Gene	106759 (Evidence)
UniGene	203952
DFCI	TC1575137, TC1593585, TC1720809
DoTS	DT.101192273, DT.101398444, DT.530980
NIA Mouse Gene Index	U037943, U090098
Consensus CDS Project	CCDS28900.1
International Mouse Knockout Project Status	Ticam1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016637	VEGA Gene Model | MGI Sequence Detail	7468	C57BL/6J
transcript	OTTMUST00000040251	VEGA | MGI Sequence Detail	2992	Not Applicable
polypeptide	OTTMUSP00000017974	VEGA | MGI Sequence Detail	732	Not Applicable

All sequences(39) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(10 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR025735	RHIM domain
InterPro	IPR017278	Toll-interleukin I receptor domain-containing adaptor protein, Ticam
Protein Ontology	PR:000001749	TIR domain-containing adapter molecule
Protein Ontology	PR:000027206	TIR domain-containing adapter molecule (mouse)

References

(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:194555 Klose CS, et al., A T-bet gradient controls the fate and function of CCR6-RORgammat+ innate lymphoid cells. Nature. 2013 Feb 14;494(7436):261-5
All references(352)

Other accession IDs

MGI:2147076