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Ticam1
Gene Detail
 Symbol
Name
ID
Ticam1
toll-like receptor adaptor molecule 1
MGI:2147032
Synonyms TICAM-1, Trif
Feature Type protein coding gene
Genetic Map
Chromosome 17
29.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr17:56269319-56276786 bp, - strand
From VEGA annotation of GRCm38

  7468 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8605  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: toll-interleukin I receptor domain-containing adaptor protein, Ticam type
Gene Tree: Ticam1

Human
homologs
Human Homolog TICAM1, toll-like receptor adaptor molecule 1
NCBI Gene ID 148022
neXtProt AC  NX_Q8IUC6
Human Synonyms  IIAE6, MyD88-3, PRVTIRB, TICAM-1, TRIF
Human Chr (Location)  19p13.3; chr19:4815924-4831742 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human TICAM1
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Chemically induced (ENU)(1) Gene trapped(4) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice are viable but exhibit abnormalities of the innate immune system.
 
Phenotype Images(1)
Interactions
Ticam1 interacts with 139 markers (Mir23b, Mir26a-2, Mir26b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (52 annotations)
Process apoptotic process, apoptotic signaling pathway, ...
Component ripoptosome
Function protein binding, protein kinase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (24)    Tissues (15)    Images (2)
Theiler Stages: 23
Assay TypeResults
RNA in situ 24
cDNA source data(43)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(43) cDNA(43)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000016637 (Evidence)
Ensembl Gene ModelENSMUSG00000047123 (Evidence)
Entrez Gene106759 (Evidence)
UniGene203952
DFCITC1575137, TC1593585, TC1720809
DoTSDT.101192273, DT.101398444, DT.530980
NIA Mouse Gene IndexU037943, U090098
Consensus CDS ProjectCCDS28900.1
International Mouse Knockout Project StatusTicam1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016637 VEGA Gene Model | MGI Sequence Detail 7468 C57BL/6J ±  kb
transcript OTTMUST00000040251 VEGA | MGI Sequence Detail 2992 Not Applicable 
polypeptide OTTMUSP00000017974 VEGA | MGI Sequence Detail 732 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(13 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR025735 RHIM domain
InterPro IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
InterPro IPR017278 Toll-interleukin I receptor domain-containing adaptor protein, Ticam
Protein Ontology PR:000001749 TIR domain-containing adapter molecule 1
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:211677 Fleige H, et al., IL-17-induced CXCL12 recruits B cells and induces follicle formation in BALT in the absence of differentiated FDCs. J Exp Med. 2014 Apr 7;211(4):643-51
All references(404)
Other
accession IDs
MGI:2147076

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory