Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes THPO
  • Mouse genes Thpo
  • Rat genes Thpol1
  • Zfish genes thpo
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Thpo

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Biological Process	GO:0035726	common myeloid progenitor cell proliferation	thpo	IDA		Zfish	PMID:24869937
Biological Process	GO:0035855	megakaryocyte development	THPO	IDA		Human	PMID:15337790
Biological Process	GO:0030219	megakaryocyte differentiation	THPO	IDA		Human	PMID:8202159
Biological Process	GO:0030099	myeloid cell differentiation	Thpo	IDA		Mouse	PMID:12393382
Biological Process	GO:0008284	positive regulation of cell population proliferation	THPO	IDA		Human	PMID:15337790
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Thpo	IDA		Mouse	MGI:MGI:5314162|PMID:22128142
Biological Process	GO:1902035	positive regulation of hematopoietic stem cell proliferation	THPO	IDA		Human	PMID:21540074
Biological Process	GO:0043410	positive regulation of MAPK cascade	THPO	IDA		Human	PMID:15337790
Biological Process	GO:0045654	positive regulation of megakaryocyte differentiation	Thpo	IDA		Mouse	MGI:MGI:5314162|PMID:22128142
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	THPO	IDA		Human	PMID:15337790
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	Thpo	IDA		Mouse	MGI:MGI:5314162|PMID:22128142
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Thpo	IDA		Mouse	MGI:MGI:5314162|PMID:22128142
Biological Process	GO:0097696	receptor signaling pathway via STAT	THPO	IDA		Human	PMID:15337790
Biological Process	GO:0002574	thrombocyte differentiation	thpo	IDA		Zfish	PMID:24869937
Biological Process	GO:0038163	thrombopoietin-mediated signaling pathway	THPO	IDA		Human	PMID:15337790
Biological Process	GO:0038163	thrombopoietin-mediated signaling pathway	Thpo	IDA		Mouse	MGI:MGI:5314162|PMID:22128142

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern