Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes THBS2
  • Mouse genes Thbs2
  • Rat genes Thbs2
  • Zfish genes thbs2a,thbs2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Thbs2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	THBS2	IPI	UniProtKB:P54290	Human	PMID:19818485
Molecular Function	GO:0005515	protein binding	Thbs2	IPI	UniProtKB:Q07954|UniProtKB:Q63722	Mouse	MGI:MGI:5298336|PMID:20472562
Molecular Function	GO:0005515	protein binding	Thbs2	IPI	UniProtKB:Q08857|UniProtKB:Q9ESB3	Mouse	MGI:MGI:3530701|PMID:15748999
Cellular Component	GO:0005604	basement membrane	Thbs2	IDA		Mouse	PMID:10669089
Cellular Component	GO:0062023	collagen-containing extracellular matrix	THBS2	HDA		Human	PMID:28327460
Cellular Component	GO:0062023	collagen-containing extracellular matrix	THBS2	HDA		Human	PMID:28675934
Cellular Component	GO:0031012	extracellular matrix	Thbs2	IDA		Mouse	PMID:10669089
Cellular Component	GO:0005576	extracellular region	THBS2	HDA		Human	PMID:27068509
Cellular Component	GO:0031091	platelet alpha granule	THBS2	IDA		Human	PMID:1737102
Biological Process	GO:0016525	negative regulation of angiogenesis	THBS2	IDA		Human	PMID:20714802
Biological Process	GO:0016525	negative regulation of angiogenesis	Thbs2	IMP		Mouse	MGI:MGI:3530701|PMID:15748999
Biological Process	GO:0016525	negative regulation of angiogenesis	Thbs2	IDA		Rat	PMID:11835157|RGD:1580070
Biological Process	GO:0016525	negative regulation of angiogenesis	Thbs2	IEP		Rat	PMID:12511771|RGD:1580067
Biological Process	GO:0051965	positive regulation of synapse assembly	Thbs2	IMP		Rat	PMID:15707899|RGD:1580068

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern