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Thbs2
Gene Detail
 Symbol
Name
ID
Thbs2
thrombospondin 2
MGI:98738
Synonyms Thbs-2, Thrombospondin-2, TSP2
Feature Type protein coding gene
Genetic Map
Chromosome 17
8.95 cM, cytoband A3-B
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr17:14665500-14694262 bp, - strand
From NCBI annotation of GRCm38

  28763 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2438  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 3 zebrafish

Protein SuperFamily: thrombospondin 1/2
Gene Tree: Thbs2

Human
homologs
Human Homolog THBS2, thrombospondin 2
NCBI Gene ID 7058
neXtProt AC  NX_P35442
Human Synonyms  TSP2
Human Chr (Location)  6q27; chr6:169215780-169254114 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human THBS2
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele display premature death, abnormal tails, marked structural and functional abnormalities in a variety of connective tissues including skin, tendon, bone, and blood vessels, accelerated wound healing, and enhanced susceptibility to experimental skin tumors.
 
Phenotype Images(4)
Interactions
Thbs2 interacts with 311 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process cell adhesion, negative regulation of angiogenesis, ...
Component basement membrane, extracellular matrix, ...
Function calcium ion binding, heparin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (78)    Tissues (54)    Images (10)
Theiler Stages: 11, 17, 20, 21, 22, 23, 24, 26, 27, 28
Assay TypeResults
Immunohistochemistry 6
RNA in situ 31
Northern blot 28
RT-PCR 1
RNase protection 12
cDNA source data(86)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(98) Genomic(8) cDNA(87) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000023885 (Evidence)
Entrez Gene21826 (Evidence)
UniGene26688
DFCITC1579291, TC1600407, TC1685432
DoTSDT.527610
NIA Mouse Gene IndexU037442
Consensus CDS ProjectCCDS49958.1
International Mouse Knockout Project StatusThbs2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 21826 NCBI Gene Model | MGI Sequence Detail 28763 C57BL/6J ±  kb
transcript NM_011581 RefSeq | MGI Sequence Detail 5922 C57BL/6 
polypeptide Q03350 UniProt | EBI | MGI Sequence Detail 1172 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(3)
Polymorphisms RFLP(2) : SNPs within 2kb(180 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008985 Concanavalin A-like lectin/glucanases superfamily
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR024731 EGF domain, merozoite surface protein 1-like
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR001791 Laminin G domain
InterPro IPR008859 Thrombospondin, C-terminal
InterPro IPR000884 Thrombospondin, type 1 repeat
InterPro IPR015455 Thrombospondin, type 2
InterPro IPR003367 Thrombospondin, type 3-like repeat
InterPro IPR017897 Thrombospondin, type 3 repeat
InterPro IPR001007 von Willebrand factor, type C
Protein Ontology PR:000000130 thrombospondin-2
Graphical View of Protein Domain Structure
References (Earliest) J:1992 Bornstein P, et al., A second thrombospondin gene in the mouse is similar in organization to thrombospondin 1 but does not respond to serum. Proc Natl Acad Sci U S A. 1991 Oct 1;88(19):8636-40
(Latest) J:210410 Chatterjee A, et al., Central corneal thickness does not correlate with TonoLab-measured IOP in several mouse strains with single transgenic mutations of matricellular proteins. Exp Eye Res. 2013 Oct;115:106-12
All references(91)
Other
accession IDs
MGD-MRK-15084, MGD-MRK-15087

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory