About   Help   FAQ
Thbs2 Gene Detail
Summary
  • Symbol
    Thbs2
  • Name
    thrombospondin 2
  • Synonyms
    Thbs-2, Thrombospondin-2, TSP2
  • Feature Type
    protein coding gene
  • IDs
    MGI:98738
    NCBI Gene: 21826
  • Gene Overview
    MyGene.info: THBS2
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:14665500-14694235 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 8.95 cM, cytoband A3-B
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    178 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98738
protein coding gene Chr17:14665500-14694262 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023165
protein coding gene Chr17:12501137-12530553 (-)
A/J MGP_AJ_G0023131
protein coding gene Chr17:12309648-12338361 (-)
AKR/J MGP_AKRJ_G0023101
protein coding gene Chr17:12213436-12242131 (-)
BALB/cJ MGP_BALBcJ_G0023133
protein coding gene Chr17:12134758-12163513 (-)
C3H/HeJ MGP_C3HHeJ_G0022894
protein coding gene Chr17:12404071-12432889 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023574
protein coding gene Chr17:13081376-13109954 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021086
protein coding gene Chr17:10348615-10376676 (-)
CAST/EiJ MGP_CASTEiJ_G0022409
protein coding gene Chr17:12341572-12371694 (-)
CBA/J MGP_CBAJ_G0022868
protein coding gene Chr17:13464458-13493039 (-)
DBA/2J MGP_DBA2J_G0023001
protein coding gene Chr17:12033493-12062427 (-)
FVB/NJ MGP_FVBNJ_G0022969
protein coding gene Chr17:11823933-11853026 (-)
LP/J MGP_LPJ_G0023075
protein coding gene Chr17:12462069-12490813 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022990
protein coding gene Chr17:13075992-13108994 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023610
protein coding gene Chr17:12440578-12471125 (-)
PWK/PhJ MGP_PWKPhJ_G0022157
protein coding gene Chr17:11468859-11497513 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021987
protein coding gene Chr17:11370857-11471250 (-)
WSB/EiJ MGP_WSBEiJ_G0022470
protein coding gene Chr17:12767745-12800645 (-)



Homology
more
  • Human Ortholog
    THBS2, thrombospondin 2
  • Vertebrate Orthologs
    12
  • Human Ortholog
    THBS2, thrombospondin 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    TSP2
  • Links
    NCBI Gene ID: 7058
    neXtProt AC: NX_P35442
    UniProt: P35442

  • Chr Location
    6q27; chr6:169215780-169254114 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 1 allele in 1 genetic background
    8 phenotypes from multigenic genotypes
    4 images
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display premature death, abnormal tails, marked structural and functional abnormalities in a variety of connective tissues including skin, tendon, bone, and blood vessels, accelerated wound healing, and enhanced susceptibility to experimental skin tumors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000023885 Ensembl Gene Model | MGI Sequence Detail 28736 C57BL/6J ±  kb
    transcript ENSMUST00000170872 Ensembl | MGI Sequence Detail 5895 Not Applicable  
    polypeptide ENSMUSP00000128308 Ensembl | MGI Sequence Detail 1172 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 100
      Genomic 9
      cDNA 88
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-15084, MGD-MRK-15087
    References
    more
    • Summaries
      All 105
      Developmental Gene Expression 21
      Gene Ontology 9
      Phenotypes 45
    • Earliest
      J:1992 Bornstein P, et al., A second thrombospondin gene in the mouse is similar in organization to thrombospondin 1 but does not respond to serum. Proc Natl Acad Sci U S A. 1991 Oct 1;88(19):8636-40
    • Latest
      J:271593 Schips TG, et al., Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability. Nat Commun. 2019 Jan 8;10(1):76

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    06/04/2019
    MGI 6.14
    The Jackson Laboratory