Thbs2
Gene Detail

Symbol Name ID

Thbs2 thrombospondin 2 MGI:98738

Synonyms

Thbs-2, Thrombospondin-2, TSP2

Feature Type

protein coding gene

Genetic Map

Chromosome 17

8.95 cM, cytoband A3-B
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

Chr17:14665500-14694262 bp, - strand From NCBI annotation of GRCm38   28763 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2438  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 3 zebrafish

Protein SuperFamily: thrombospondin 1/2
Gene Tree: Thbs2

Human homologs

Human Homolog		THBS2, thrombospondin 2
NCBI Gene ID		7058
neXtProt AC		NX_P35442
Human Synonyms		TSP2
Human Chr (Location)		6q27; chr6:169615875-169654137 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human THBS2

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Mice homozygous for a knock-out allele display premature death, abnormal tails, marked structural and functional abnormalities in a variety of connective tissues including skin, tendon, bone, and blood vessels, accelerated wound healing, and enhanced susceptibility to experimental skin tumors.

 
Phenotype Images(4)

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	cell adhesion, negative regulation of angiogenesis, ...
Component	basement membrane, extracellular matrix, ...
Function	calcium ion binding, heparin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (14 records)
Data Summary: Results (78)    Tissues (53)    Images (10)
Theiler Stages: 11, 17, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	6
RNA in situ	31
Northern blot	28
RT-PCR	1
RNase protection	12

cDNA source data(85)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(97) Genomic(8) cDNA(86) Primer pair(2) Other(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000023885 (Evidence)
Entrez Gene	21826 (Evidence)
UniGene	26688
DFCI	TC1579291, TC1600407, TC1685432
DoTS	DT.527610
NIA Mouse Gene Index	U037442
Consensus CDS Project	CCDS49958.1
International Mouse Knockout Project Status	Thbs2

Sequences

Length	Strain/Species
genomic	21826	NCBI Gene Model | MGI Sequence Detail	28763	C57BL/6J
transcript	NM_011581	RefSeq | MGI Sequence Detail	5922	C57BL/6
polypeptide	Q03350	UniProt | EBI | MGI Sequence Detail	1172	Not Applicable

All sequences(25) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(2) : SNPs(153 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008985	Concanavalin A-like lectin/glucanases superfamily
InterPro	IPR013320	Concanavalin A-like lectin/glucanase, subgroup
InterPro	IPR024731	EGF domain, merozoite surface protein 1-like
InterPro	IPR001881	EGF-like calcium-binding
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR001791	Laminin G domain
InterPro	IPR008859	Thrombospondin, C-terminal
InterPro	IPR000884	Thrombospondin, type 1 repeat
InterPro	IPR015455	Thrombospondin, type 2
InterPro	IPR003367	Thrombospondin, type 3-like repeat
InterPro	IPR017897	Thrombospondin, type 3 repeat
InterPro	IPR001007	von Willebrand factor, type C
Protein Ontology	PR:000000130	thrombospondin-2

Graphical View of Protein Domain Structure

References

(Earliest) J:1992 Bornstein P, et al., A second thrombospondin gene in the mouse is similar in organization to thrombospondin 1 but does not respond to serum. Proc Natl Acad Sci U S A. 1991 Oct 1;88(19):8636-40
(Latest) J:181974 Seo S, et al., Forkhead box transcription factor FoxC1 preserves corneal transparency by regulating vascular growth. Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):2015-20
All references(88)

Other accession IDs

MGD-MRK-15084, MGD-MRK-15087