Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TGFB1I1
  • Mouse genes Tgfb1i1
  • Rat genes Tgfb1i1
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tgfb1i1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0070411	I-SMAD binding	TGFB1I1	IPI	UniProtKB:O15105	Human	PMID:18762808
Molecular Function	GO:0070411	I-SMAD binding	Tgfb1i1	IPI	UniProtKB:O88406	Rat	PMID:18762808|RGD:8553475
Molecular Function	GO:0050681	nuclear androgen receptor binding	TGFB1I1	IPI	UniProtKB:P10275	Human	PMID:10075738
Molecular Function	GO:0005515	protein binding	TGFB1I1	IPI	UniProtKB:P13612	Human	PMID:10604475
Molecular Function	GO:0005515	protein binding	TGFB1I1	IPI	UniProtKB:P31645	Human	PMID:12177201
Molecular Function	GO:0005515	protein binding	TGFB1I1	IPI	UniProtKB:Q9BUZ4	Human	PMID:16330715
Molecular Function	GO:0005515	protein binding	TGFB1I1	IPI	UniProtKB:Q8TD08	Human	PMID:16624805
Molecular Function	GO:0005515	protein binding	TGFB1I1	IPI	UniProtKB:Q05397	Human	PMID:21900206
Molecular Function	GO:0005515	protein binding	TGFB1I1	IPI	UniProtKB:O68743	Human	PMID:21911467
Molecular Function	GO:0005515	protein binding	TGFB1I1	IPI	UniProtKB:Q05397	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	TGFB1I1	IPI	UniProtKB:Q05397	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	TGFB1I1	IPI	UniProtKB:Q05397	Human	PMID:9756887
Molecular Function	GO:0005515	protein binding	Tgfb1i1	IPI	UniProtKB:Q05397	Mouse	MGI:MGI:3828419|PMID:9756887
Molecular Function	GO:0005515	protein binding	Tgfb1i1	IPI	UniProtKB:Q8C115	Mouse	MGI:MGI:5487756|PMID:22832517
Molecular Function	GO:0005515	protein binding	Tgfb1i1	IPI	RGD:61306	Rat	PMID:11546764|RGD:634226
Molecular Function	GO:0048495	Roundabout binding	TGFB1I1	IPI	UniProtKB:Q8C310	Human	PMID:19855388
Molecular Function	GO:0003713	transcription coactivator activity	TGFB1I1	IDA		Human	PMID:10075738
Molecular Function	GO:0003713	transcription coactivator activity	TGFB1I1	IMP		Human	PMID:16624805
Cellular Component	GO:0062023	collagen-containing extracellular matrix	TGFB1I1	HDA		Human	PMID:20551380
Cellular Component	GO:0005829	cytosol	TGFB1I1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005925	focal adhesion	TGFB1I1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005925	focal adhesion	TGFB1I1	HDA		Human	PMID:21423176
Cellular Component	GO:0005925	focal adhesion	Tgfb1i1	IDA		Mouse	PMID:25071083
Cellular Component	GO:0005925	focal adhesion	Tgfb1i1	IDA		Mouse	PMID:11784865
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	TGFB1I1	IDA		Human	GO_REF:0000052
Biological Process	GO:0045165	cell fate commitment	Tgfb1i1	IGI	MGI:MGI:97747	Mouse	PMID:15687259
Biological Process	GO:0030855	epithelial cell differentiation	Tgfb1i1	IGI	MGI:MGI:97747	Mouse	PMID:15687259
Biological Process	GO:0045444	fat cell differentiation	Tgfb1i1	IGI	MGI:MGI:97747	Mouse	PMID:15687259
Biological Process	GO:0016331	morphogenesis of embryonic epithelium	Tgfb1i1	IMP		Mouse	PMID:15687259
Biological Process	GO:0045599	negative regulation of fat cell differentiation	Tgfb1i1	IGI	MGI:MGI:97747	Mouse	PMID:15687259
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	TGFB1I1	IDA		Human	PMID:18762808
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	TGFB1I1	IDA		Human	PMID:10075738
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	TGFB1I1	IDA		Human	PMID:18762808
Biological Process	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	TGFB1I1	IDA		Human	PMID:18762808
Biological Process	GO:0009408	response to heat	Tgfb1i1	IDA		Rat	PMID:11546764|RGD:634226
Biological Process	GO:0030579	ubiquitin-dependent SMAD protein catabolic process	TGFB1I1	IDA		Human	PMID:18762808

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern