Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TFEC
  • Mouse genes Tfec
  • Rat genes Tfec
  • Zfish genes tfec
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tfec

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Tfec	IDA		Rat	PMID:8336698|RGD:70037
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	TFEC	IDA		Human	PMID:9256061
Molecular Function	GO:0005515	protein binding	TFEC	IPI	UniProtKB:Q9H115	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TFEC	IPI	UniProtKB:Q9H1M4	Human	PMID:25416956
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Tfec	IDA		Rat	PMID:8336698|RGD:70037
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	TFEC	IDA		Human	PMID:28473536
Cellular Component	GO:0005829	cytosol	TFEC	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	TFEC	IDA		Human	GO_REF:0000052
Biological Process	GO:0034605	cellular response to heat	Tfec	IDA		Mouse	PMID:18755693
Biological Process	GO:0061386	closure of optic fissure	tfec	IGI	ZFIN:ZDB-GENO-211027-12	Zfish	PMID:32541011
Biological Process	GO:0060216	definitive hemopoiesis	tfec	IMP	ZFIN:ZDB-GENO-170201-6	Zfish	PMID:27402973
Biological Process	GO:0061484	hematopoietic stem cell homeostasis	tfec	IMP	ZFIN:ZDB-GENO-170201-6	Zfish	PMID:27402973
Biological Process	GO:0061484	hematopoietic stem cell homeostasis	tfec	IGI	ZFIN:ZDB-GENE-070424-2	Zfish	PMID:27402973
Biological Process	GO:0071425	hematopoietic stem cell proliferation	tfec	IMP		Zfish	PMID:27402973
Biological Process	GO:0030097	hemopoiesis	tfec	IMP	ZFIN:ZDB-GENO-170201-6	Zfish	PMID:27402973
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	TFEC	IDA		Human	PMID:9256061
Biological Process	GO:0014036	neural crest cell fate specification	tfec	IMP	ZFIN:ZDB-GENO-211027-11	Zfish	PMID:33439865
Biological Process	GO:0050945	positive regulation of iridophore differentiation	tfec	IMP	ZFIN:ZDB-GENO-211027-11	Zfish	PMID:33439865
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	TFEC	IDA		Human	PMID:9256061
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Tfec	IDA		Rat	PMID:8336698|RGD:70037
Biological Process	GO:0006355	regulation of DNA-templated transcription	Tfec	IDA		Rat	PMID:8336698|RGD:70037

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern