Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TFAM
  • Mouse genes Tfam
  • Rat genes Tfam
  • Zfish genes tfam
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tfam

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	TFAM	IDA		Human	PMID:18063578
Molecular Function	GO:0031072	heat shock protein binding	Tfam	IPI	RGD:628878	Rat	PMID:22003111|RGD:5686899
Molecular Function	GO:0001018	mitochondrial promoter sequence-specific DNA binding	TFAM	IDA		Human	PMID:19304746
Molecular Function	GO:0001018	mitochondrial promoter sequence-specific DNA binding	Tfam	IDA		Mouse	PMID:2628167
Molecular Function	GO:0034246	mitochondrial transcription factor activity	TFAM	IMP		Human	PMID:22037171
Molecular Function	GO:0005515	protein binding	TFAM	IPI	UniProtKB:Q8WVM0	Human	PMID:12897151
Molecular Function	GO:0005515	protein binding	TFAM	IPI	UniProtKB:Q15041	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TFAM	IPI	UniProtKB:Q6RW13	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	TFAM	IPI	UniProtKB:O00411,UniProtKB:O43524,UniProtKB:Q9NTG7	Human	PMID:29445193
Molecular Function	GO:0005515	protein binding	TFAM	IPI	UniProtKB:O14880	Human	PMID:29568061
Molecular Function	GO:0005515	protein binding	TFAM	IPI	UniProtKB:O14880	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TFAM	IPI	UniProtKB:O60635	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TFAM	IPI	UniProtKB:P02808	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TFAM	IPI	UniProtKB:Q4VAQ0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TFAM	IPI	UniProtKB:Q6RW13-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	TFAM	IPI	UniProtKB:Q9NZ01	Human	PMID:32296183
Molecular Function	GO:0003723	RNA binding	TFAM	HDA		Human	PMID:22658674
Molecular Function	GO:0003723	RNA binding	TFAM	HDA		Human	PMID:22681889
Molecular Function	GO:0043565	sequence-specific DNA binding	TFAM	IDA		Human	PMID:29445193
Molecular Function	GO:0001223	transcription coactivator binding	Tfam	IPI	RGD:620925	Rat	PMID:23297307|RGD:10059660
Cellular Component	GO:0005759	mitochondrial matrix	TFAM	IDA		Human	PMID:29445193
Cellular Component	GO:0042645	mitochondrial nucleoid	TFAM	IDA		Human	PMID:18063578
Cellular Component	GO:0042645	mitochondrial nucleoid	TFAM	IDA		Human	PMID:24703694
Cellular Component	GO:0042645	mitochondrial nucleoid	Tfam	IDA		Mouse	PMID:24703694
Cellular Component	GO:0005739	mitochondrion	TFAM	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	Tfam	IDA		Mouse	PMID:2628167
Cellular Component	GO:0005739	mitochondrion	Tfam	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Tfam	IDA		Mouse	PMID:8673128
Cellular Component	GO:0005739	mitochondrion	Tfam	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Tfam	IDA		Rat	PMID:11882497|RGD:730138
Cellular Component	GO:0005634	nucleus	TFAM	HDA		Human	PMID:21630459
Cellular Component	GO:0032991	protein-containing complex	TFAM	IDA		Human	PMID:29445193
Biological Process	GO:0033108	mitochondrial respiratory chain complex assembly	Tfam	IMP	MGI:MGI:1860962,MGI:MGI:2177173	Mouse	PMID:11259653
Biological Process	GO:0006390	mitochondrial transcription	TFAM	IMP		Human	PMID:22037171
Biological Process	GO:0006390	mitochondrial transcription	Tfam	IDA		Mouse	PMID:2628167
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	TFAM	IDA		Human	PMID:20410300
Biological Process	GO:0006391	transcription initiation at mitochondrial promoter	TFAM	IDA		Human	PMID:20410300
Biological Process	GO:0006391	transcription initiation at mitochondrial promoter	TFAM	IDA		Human	PMID:29149603

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern