Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Syt1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes SYT1
- Mouse genes Syt1
- Rat genes Syt1
- Zfish genes syt1a,syt1b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Syt1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	Syt1	IDA		Mouse	PMID:15197251
Molecular Function	GO:0005509	calcium ion binding	Syt1	IDA		Rat	PMID:15340165\|RGD:7205658
Molecular Function	GO:0005509	calcium ion binding	Syt1	IDA		Rat	PMID:22447935\|RGD:7205653
Molecular Function	GO:0005509	calcium ion binding	Syt1	IMP		Rat	PMID:22711810\|RGD:7205652
Molecular Function	GO:0061891	calcium ion sensor activity	Syt1	IDA		Mouse	PMID:21521611
Molecular Function	GO:0005544	calcium-dependent phospholipid binding	Syt1	IDA		Mouse	MGI:MGI:5795832\|PMID:8626542
Molecular Function	GO:0005544	calcium-dependent phospholipid binding	Syt1	IDA		Rat	PMID:22711810\|RGD:7205652
Molecular Function	GO:0005544	calcium-dependent phospholipid binding	Syt1	IDA		Rat	PMID:7791877\|RGD:61762
Molecular Function	GO:0005544	calcium-dependent phospholipid binding	Syt1	IDA		Rat	PMID:8253763\|RGD:10047263
Molecular Function	GO:0048306	calcium-dependent protein binding	Syt1	IPI	UniProtKB:Q00262	Mouse	MGI:MGI:3584221\|PMID:15774481
Molecular Function	GO:0048306	calcium-dependent protein binding	Syt1	IDA		Rat	PMID:10397765\|RGD:11535116
Molecular Function	GO:0048306	calcium-dependent protein binding	Syt1	IDA		Rat	PMID:20688915\|RGD:11535104
Molecular Function	GO:0048306	calcium-dependent protein binding	Syt1	IDA		Rat	PMID:22711810\|RGD:7205652
Molecular Function	GO:0048306	calcium-dependent protein binding	Syt1	IDA		Rat	PMID:9830048\|RGD:8553400
Molecular Function	GO:0005516	calmodulin binding	Syt1	IDA		Rat	PMID:2333096\|RGD:729959
Molecular Function	GO:0030276	clathrin binding	Syt1	IDA		Rat	PMID:7791877\|RGD:61762
Molecular Function	GO:0042802	identical protein binding	Syt1	IPI	UniProtKB:P21707	Rat	PMID:8621455\|RGD:15023468
Molecular Function	GO:0042802	identical protein binding	Syt1	IPI	UniProtKB:P21707	Rat	PMID:9830048\|RGD:8553400
Molecular Function	GO:0050750	low-density lipoprotein particle receptor binding	SYT1	IDA		Human	PMID:15082773
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	Syt1	IDA		Rat	PMID:12860971\|RGD:11079189
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	Syt1	IDA		Rat	PMID:22447935\|RGD:7205653
Molecular Function	GO:0001786	phosphatidylserine binding	Syt1	IDA		Rat	PMID:12860971\|RGD:11079189
Molecular Function	GO:0001786	phosphatidylserine binding	Syt1	IDA		Rat	PMID:18508778\|RGD:7241021
Molecular Function	GO:0001786	phosphatidylserine binding	Syt1	IDA		Rat	PMID:20688915\|RGD:11535104
Molecular Function	GO:0005543	phospholipid binding	Syt1	IDA		Rat	PMID:2333096\|RGD:729959
Molecular Function	GO:0005543	phospholipid binding	Syt1	IDA		Rat	PMID:9830048\|RGD:8553400
Molecular Function	GO:0005515	protein binding	SYT1	IPI	UniProtKB:O00305-2	Human	PMID:16525042
Molecular Function	GO:0005515	protein binding	SYT1	IPI	UniProtKB:Q8TAC9	Human	PMID:19234194
Molecular Function	GO:0005515	protein binding	SYT1	IPI	UniProtKB:Q99584	Human	PMID:19284995
Molecular Function	GO:0005515	protein binding	SYT1	IPI	UniProtKB:Q9Y6K9	Human	PMID:20098747
Molecular Function	GO:0005515	protein binding	SYT1	IPI	UniProtKB:P16473	Human	PMID:28298427
Molecular Function	GO:0005515	protein binding	SYT1	IPI	UniProtKB:O43169	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SYT1	IPI	UniProtKB:O95159	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SYT1	IPI	UniProtKB:P30301	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SYT1	IPI	UniProtKB:P30519	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SYT1	IPI	UniProtKB:Q12982	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SYT1	IPI	UniProtKB:Q8N6G5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SYT1	IPI	UniProtKB:Q8TBM7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SYT1	IPI	UniProtKB:Q8WVV5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SYT1	IPI	UniProtKB:Q96F15	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SYT1	IPI	UniProtKB:Q9H115	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SYT1	IPI	UniProtKB:Q9H2L4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SYT1	IPI	UniProtKB:Q9P0S9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SYT1	IPI	UniProtKB:Q9Y5Z9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Syt1	IPI	UniProtKB:Q8TAC9	Mouse	MGI:MGI:3837083\|PMID:19234194
Molecular Function	GO:0005515	protein binding	Syt1	IPI	UniProtKB:Q8JZZ9	Mouse	MGI:MGI:3525418\|PMID:15466855
Molecular Function	GO:0005515	protein binding	Syt1	IPI	UniProtKB:E9PUL5	Mouse	MGI:MGI:5792766\|PMID:27052163
Molecular Function	GO:0005515	protein binding	Syt1	IPI	UniProtKB:P49769	Mouse	MGI:MGI:5780348\|PMID:27036734
Molecular Function	GO:0005515	protein binding	Syt1	IPI	PR:Q9ER97	Mouse	PMID:22079573
Molecular Function	GO:0005515	protein binding	Syt1	IPI	PR:P83741	Mouse	PMID:15350218
Molecular Function	GO:0005515	protein binding	Syt1	IPI	PR:Q8BZ60	Mouse	PMID:14726597
Molecular Function	GO:0005515	protein binding	Syt1	IPI	UniProtKB:P04775	Rat	PMID:10737807\|RGD:8553647
Molecular Function	GO:0005515	protein binding	Syt1	IPI	UniProtKB:Q00954	Rat	PMID:10737807\|RGD:8553647
Molecular Function	GO:0005515	protein binding	Syt1	IPI	UniProtKB:Q8WXE9	Rat	PMID:11454741\|RGD:8554149
Molecular Function	GO:0005515	protein binding	Syt1	IPI	UniProtKB:P18484	Rat	PMID:11502761\|RGD:8553705
Molecular Function	GO:0005515	protein binding	Syt1	IPI	RGD:620073	Rat	PMID:14960300\|RGD:2314877
Molecular Function	GO:0005515	protein binding	Syt1	IPI	RGD:620053	Rat	PMID:17088214\|RGD:5684965
Molecular Function	GO:0005515	protein binding	Syt1	IPI	UniProtKB:P97610	Rat	PMID:17190793\|RGD:10047304
Molecular Function	GO:0005515	protein binding	Syt1	IPI	UniProtKB:P50232	Rat	PMID:18046461\|RGD:8554794
Molecular Function	GO:0005515	protein binding	Syt1	IPI	UniProtKB:P90761	Rat	PMID:18166656\|RGD:8554580
Molecular Function	GO:0005515	protein binding	Syt1	IPI	RGD:70945	Rat	PMID:19132534\|RGD:7205655
Molecular Function	GO:0005515	protein binding	Syt1	IPI	UniProtKB:P60881	Rat	PMID:20173763\|RGD:13432278
Molecular Function	GO:0005515	protein binding	Syt1	IPI	UniProtKB:P63045	Rat	PMID:20173763\|RGD:13432278
Molecular Function	GO:0005515	protein binding	Syt1	IPI	UniProtKB:Q4KM98	Rat	PMID:23792689\|RGD:12793033
Molecular Function	GO:0005515	protein binding	Syt1	IPI	UniProtKB:O35526	Rat	PMID:26280336\|RGD:13432225
Molecular Function	GO:0005515	protein binding	Syt1	IPI	UniProtKB:O35526	Rat	PMID:26437117\|RGD:11060704
Molecular Function	GO:0005515	protein binding	Syt1	IPI	UniProtKB:P63012	Rat	PMID:28057568\|RGD:14390053
Molecular Function	GO:0005515	protein binding	Syt1	IPI	UniProtKB:P63045	Rat	PMID:8567678\|RGD:2301258
Molecular Function	GO:0005515	protein binding	Syt1	IPI	UniProtKB:Q02563	Rat	PMID:8910372\|RGD:8553938
Molecular Function	GO:0005515	protein binding	Syt1	IPI	RGD:2244	Rat	PMID:9303303\|RGD:10054440
Molecular Function	GO:0005515	protein binding	Syt1	IPI	UniProtKB:P18484	Rat	PMID:9830048\|RGD:8553400
Molecular Function	GO:0005515	protein binding	Syt1	IPI	UniProtKB:P40748	Rat	PMID:9830048\|RGD:8553400
Molecular Function	GO:0005515	protein binding	Syt1	IPI	UniProtKB:P50232	Rat	PMID:9830048\|RGD:8553400
Molecular Function	GO:0005515	protein binding	Syt1	IPI	UniProtKB:Q02294	Rat	PMID:9830048\|RGD:8553400
Molecular Function	GO:0046982	protein heterodimerization activity	Syt1	IPI	UniProtKB:P50232	Rat	PMID:10397765\|RGD:11535116
Molecular Function	GO:0000149	SNARE binding	Syt1	IPI	UniProtKB:P60881	Rat	PMID:12526776\|RGD:10047386
Molecular Function	GO:0000149	SNARE binding	Syt1	IPI	UniProtKB:P63045	Rat	PMID:12526776\|RGD:10047386
Molecular Function	GO:0000149	SNARE binding	Syt1	IDA		Rat	PMID:12860971\|RGD:11079189
Molecular Function	GO:0000149	SNARE binding	Syt1	IDA		Rat	PMID:18508778\|RGD:7241021
Molecular Function	GO:0000149	SNARE binding	Syt1	IDA		Rat	PMID:19132534\|RGD:7205655
Molecular Function	GO:0000149	SNARE binding	Syt1	IPI	UniProtKB:P32851,UniProtKB:P60881	Rat	PMID:20688915\|RGD:11535104
Molecular Function	GO:0000149	SNARE binding	Syt1	IDA		Rat	PMID:22711810\|RGD:7205652
Molecular Function	GO:0019905	syntaxin binding	Syt1	IPI	UniProtKB:P50279	Rat	PMID:10397765\|RGD:11535116
Molecular Function	GO:0019905	syntaxin binding	Syt1	IPI	UniProtKB:Q08850	Rat	PMID:10397765\|RGD:11535116
Molecular Function	GO:0019905	syntaxin binding	Syt1	IDA		Rat	PMID:7791877\|RGD:61762
Molecular Function	GO:0017075	syntaxin-1 binding	Syt1	IDA		Mouse	MGI:MGI:3803800\|PMID:18703708
Molecular Function	GO:0017075	syntaxin-1 binding	Syt1	IPI	UniProtKB:P32851	Rat	PMID:10397765\|RGD:11535116
Molecular Function	GO:0017075	syntaxin-1 binding	Syt1	IDA		Rat	PMID:12526776\|RGD:10047386
Molecular Function	GO:0017075	syntaxin-1 binding	Syt1	IDA		Rat	PMID:22711810\|RGD:7205652
Molecular Function	GO:0030348	syntaxin-3 binding	Syt1	IPI	UniProtKB:Q08849	Rat	PMID:10397765\|RGD:11535116
Cellular Component	GO:0030424	axon	Syt1	IDA		Mouse	MGI:MGI:5795818\|PMID:21576241
Cellular Component	GO:0005737	cytoplasm	SYT1	IDA		Human	PMID:24327345
Cellular Component	GO:0005737	cytoplasm	Syt1	IDA		Rat	PMID:10967100\|RGD:633422
Cellular Component	GO:0031045	dense core granule	Syt1	IDA		Mouse	MGI:MGI:3795609\|PMID:18468511
Cellular Component	GO:0031045	dense core granule	Syt1	IDA		Rat	PMID:11751925\|RGD:2311146
Cellular Component	GO:0031045	dense core granule	Syt1	IDA		Rat	PMID:21551071\|RGD:7205660
Cellular Component	GO:0031045	dense core granule	Syt1	IDA		Rat	PMID:22366033\|RGD:8553894
Cellular Component	GO:0060076	excitatory synapse	Syt1	IDA		Rat	PMID:19730411\|RGD:8554379
Cellular Component	GO:0098978	glutamatergic synapse	Syt1	IDA		Mouse	PMID:7954835
Cellular Component	GO:0098978	glutamatergic synapse	Syt1	IEP		Mouse	PMID:7954835
Cellular Component	GO:0098978	glutamatergic synapse	Syt1	IMP		Mouse	PMID:7954835
Cellular Component	GO:0005794	Golgi apparatus	Syt1	IDA		Mouse	PMID:14622145
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	Syt1	IDA		Rat	PMID:7298720\|RGD:13702422
Cellular Component	GO:0043229	intracellular organelle	Syt1	IDA		Rat	PMID:10340764\|RGD:4892571
Cellular Component	GO:0043005	neuron projection	Syt1	IDA		Mouse	MGI:MGI:4941068\|PMID:21307259
Cellular Component	GO:0043005	neuron projection	Syt1	IDA		Mouse	PMID:14622145
Cellular Component	GO:0043005	neuron projection	Syt1	IDA		Mouse	PMID:15197251
Cellular Component	GO:0044306	neuron projection terminus	Syt1	IDA		Rat	PMID:10397765\|RGD:11535116
Cellular Component	GO:0005886	plasma membrane	Syt1	IDA		Rat	PMID:18179895\|RGD:8553826
Cellular Component	GO:0042734	presynaptic membrane	Syt1	IDA		Mouse	PMID:15197251
Cellular Component	GO:0030141	secretory granule	Syt1	IDA		Mouse	PMID:12145198
Cellular Component	GO:0030141	secretory granule	Syt1	IDA		Rat	PMID:15015935\|RGD:7241274
Cellular Component	GO:0008021	synaptic vesicle	Syt1	IDA		Mouse	PMID:17360631
Cellular Component	GO:0008021	synaptic vesicle	Syt1	IDA		Mouse	PMID:16407767
Cellular Component	GO:0008021	synaptic vesicle	Syt1	IDA		Rat	PMID:17110340\|RGD:12050113
Cellular Component	GO:0008021	synaptic vesicle	Syt1	IDA		Rat	PMID:18179895\|RGD:8553826
Cellular Component	GO:0030672	synaptic vesicle membrane	Syt1	IDA		Mouse	PMID:15071120
Cellular Component	GO:0030672	synaptic vesicle membrane	Syt1	IDA		Rat	PMID:7298720\|RGD:13702422
Cellular Component	GO:0030672	synaptic vesicle membrane	Syt1	IDA		Rat	PMID:17110340\|RGD:12050113
Cellular Component	GO:0030672	synaptic vesicle membrane	Syt1	IDA		Rat	PMID:23792689\|RGD:12793033
Cellular Component	GO:0043195	terminal bouton	Syt1	HDA		Rat	PMID:24876496\|RGD:10047219
Biological Process	GO:0007420	brain development	Syt1	IEP		Rat	PMID:8872307\|RGD:730127
Biological Process	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter	Syt1	IMP	MGI:MGI:1857252	Mouse	PMID:21521611
Biological Process	GO:0099502	calcium-dependent activation of synaptic vesicle fusion	Syt1	IDA		Mouse	PMID:7954835
Biological Process	GO:0099502	calcium-dependent activation of synaptic vesicle fusion	Syt1	IEP		Mouse	PMID:7954835
Biological Process	GO:0099502	calcium-dependent activation of synaptic vesicle fusion	Syt1	IMP		Mouse	PMID:7954835
Biological Process	GO:0071277	cellular response to calcium ion	Syt1	IMP		Rat	PMID:12526776\|RGD:10047386
Biological Process	GO:0005513	detection of calcium ion	Syt1	IDA		Rat	PMID:22229667\|RGD:7205654
Biological Process	GO:0098746	fast, calcium ion-dependent exocytosis of neurotransmitter	Syt1	IDA		Mouse	MGI:MGI:3040539\|PMID:12526776
Biological Process	GO:0098746	fast, calcium ion-dependent exocytosis of neurotransmitter	Syt1	IMP		Mouse	MGI:MGI:69538\|PMID:7954835
Biological Process	GO:0098746	fast, calcium ion-dependent exocytosis of neurotransmitter	Syt1	IMP		Mouse	MGI:MGI:3653150\|PMID:9194562
Biological Process	GO:0007269	neurotransmitter secretion	Syt1	IDA		Mouse	PMID:15197251
Biological Process	GO:0045956	positive regulation of calcium ion-dependent exocytosis	Syt1	IDA		Rat	PMID:21551071\|RGD:7205660
Biological Process	GO:1903235	positive regulation of calcium ion-dependent exocytosis of neurotransmitter	Syt1	IMP		Mouse	MGI:MGI:2179533\|PMID:11242035
Biological Process	GO:1903861	positive regulation of dendrite extension	SYT1	IDA		Human	PMID:23999003
Biological Process	GO:0033603	positive regulation of dopamine secretion	Syt1	IMP		Rat	PMID:28370453\|RGD:15023476
Biological Process	GO:0050806	positive regulation of synaptic transmission	Syt1	IMP		Mouse	MGI:MGI:69538\|PMID:7954835
Biological Process	GO:0031340	positive regulation of vesicle fusion	Syt1	IDA		Rat	PMID:18508778\|RGD:7241021
Biological Process	GO:0031340	positive regulation of vesicle fusion	Syt1	IDA		Rat	PMID:20688915\|RGD:11535104
Biological Process	GO:0051291	protein heterooligomerization	Syt1	IPI	UniProtKB:P40748	Rat	PMID:9830048\|RGD:8553400
Biological Process	GO:0051291	protein heterooligomerization	Syt1	IPI	UniProtKB:P50232	Rat	PMID:9830048\|RGD:8553400
Biological Process	GO:0017158	regulation of calcium ion-dependent exocytosis	Syt1	IMP		Mouse	MGI:MGI:3761204\|PMID:11562488
Biological Process	GO:0017158	regulation of calcium ion-dependent exocytosis	Syt1	IMP		Rat	PMID:11751925\|RGD:2311146
Biological Process	GO:0017158	regulation of calcium ion-dependent exocytosis	Syt1	IMP		Rat	PMID:12860971\|RGD:11079189
Biological Process	GO:0017158	regulation of calcium ion-dependent exocytosis	Syt1	IMP		Rat	PMID:17686463\|RGD:7205657
Biological Process	GO:0014059	regulation of dopamine secretion	Syt1	IMP		Mouse	MGI:MGI:5795818\|PMID:21576241
Biological Process	GO:1903305	regulation of regulated secretory pathway	Syt1	IMP		Rat	PMID:12526776\|RGD:10047386
Biological Process	GO:0051966	regulation of synaptic transmission, glutamatergic	Syt1	IMP		Mouse	MGI:MGI:3040539\|PMID:12526776
Biological Process	GO:2000300	regulation of synaptic vesicle exocytosis	Syt1	IDA		Rat	PMID:28057568\|RGD:14390053
Biological Process	GO:0051592	response to calcium ion	Syt1	IDA		Rat	PMID:18508778\|RGD:7241021
Biological Process	GO:0061669	spontaneous neurotransmitter secretion	Syt1	IMP	MGI:MGI:1857252	Mouse	PMID:21521611
Biological Process	GO:0016079	synaptic vesicle exocytosis	Syt1	IMP	MGI:MGI:1857252	Mouse	PMID:21040848
Biological Process	GO:0071911	synchronous neurotransmitter secretion	Syt1	IMP	MGI:MGI:1857252	Mouse	PMID:21521611
Biological Process	GO:0048278	vesicle docking	Syt1	IDA		Rat	PMID:22229667\|RGD:7205654

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.