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Syt1 Gene Detail
Summary
  • Symbol
    Syt1
  • Name
    synaptotagmin I
  • Synonyms
    G630098F17Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:99667
    NCBI Gene: 20979
  • Gene Overview
    MyGene.info: SYT1
Location & Maps
more
  • Sequence Map
    Chr10:108497650-109010982 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      513333 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 56.52 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    SYT1, synaptotagmin 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SYT1, synaptotagmin 1
    Orthology source: HomoloGene
  • Synonyms
    P65, SVP65, SYT
  • Links
    NCBI Gene ID: 6857
    neXtProt AC: NX_P21579

  • Chr Location
    12cen-q21; chr12:78863993-79452008 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 7 alleles in 5 genetic backgrounds
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    17
  • Chemically induced (other)
    1
  • Gene trapped
    7
  • Targeted
    9
  • Genomic Mutations
    1 involving Syt1
  • Incidental Mutations
Homozygous null mice do not suckle, show impaired synaptic transmission and Ca2+-evoked neurotransmitter release, and die by 48 hrs of life. Knock-in mice bearing a missense mutation show enhanced synaptic depression while those carrying a point mutationshow reduced synaptic release probability.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016266 VEGA Gene Model | MGI Sequence Detail 513333 C57BL/6J ±  kb
transcript OTTMUST00000039005 VEGA | MGI Sequence Detail 4820 Not Applicable  
polypeptide OTTMUSP00000017428 VEGA | MGI Sequence Detail 421 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2776 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 25
    cDNA 23
    Primer pair 2

    Microarray probesets 8
Other
Accession IDs
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MGD-MRK-16452, MGI:2143817
References
more
  • Summaries
    All 119
    Developmental Gene Expression 21
    Gene Ontology 26
    Phenotypes 38
  • Earliest
    J:18436 Mayanil CS, et al., Synaptic vesicle and synaptic membrane glycoproteins during pre- and postnatal development of mouse cerebral cortex, cerebellum and spinal cord. Dev Neurosci. 1993;15(2):133-45
  • Latest
    J:226819 Coate TM, et al., Neuropilin-2/Semaphorin-3F-mediated repulsion promotes inner hair cell innervation by spiral ganglion neurons. Elife. 2015;4

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory