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Syt1
Gene Detail
Symbol

Name
ID
Syt1
synaptotagmin I
MGI:99667
Synonyms
G630098F17Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 10
56.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr10:108497650-109010982 bp, - strand
From VEGA annotation of GRCm38

  513333 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4122  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: SYT1
Protein SuperFamily: B/K protein/synaptotagmin
Gene Tree: Syt1

Human
homologs
SYT1, synaptotagmin I
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6857
neXtProt AC: NX_P21579

Human Synonyms: P65, SVP65, SYT

Human Chr (Location): 12cen-q21; chr12:78863993-79452008 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(7) Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice do not suckle, show impaired synaptic transmission and Ca2+-evoked neurotransmitter release, and die by 48 hrs of life. Knock-in mice bearing a missense mutation show enhanced synaptic depression while those carrying a point mutation show reduced synaptic release probability.
 
Interactions
Syt1 interacts with 443 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (20 records)
Data Summary: Results (705)    Tissues (174)    Images (65)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 682
Western blot 17
RT-PCR 6
cDNA source data(17)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA SYT1 ; Xenbase syt1 ; ZFIN syt1a    NEW 
Molecular
reagents
All nucleic(25) cDNA(23) Primer pair(2)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000016266 (Evidence)
Ensembl Gene Model ENSMUSG00000035864 (Evidence)
Entrez Gene 20979 (Evidence)
DFCI TC1576414, TC1598701, TC1602015, TC1621289
DoTS DT.101335131, DT.101390352, DT.482188, DT.94141720, DT.97387564
NIA Mouse Gene Index U032208
Consensus CDS Project CCDS24163.1
International Mouse Phenotyping Consortium Status Syt1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016266 VEGA Gene Model | MGI Sequence Detail 513333 C57BL/6J ±  kb
transcript OTTMUST00000047565 VEGA | MGI Sequence Detail 4745 Not Applicable 
polypeptide OTTMUSP00000021532 VEGA | MGI Sequence Detail 421 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(14) UniProt(4)
Polymorphisms
RFLP(2) : SNPs within 2kb(2794 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR001565 Synaptotagmin
InterPro IPR015428 Synaptotagmin 1
Protein Ontology PR:000015894 synaptotagmin-1
References
(Earliest) J:18436 Mayanil CS, et al., Synaptic vesicle and synaptic membrane glycoproteins during pre- and postnatal development of mouse cerebral cortex, cerebellum and spinal cord. Dev Neurosci. 1993;15(2):133-45
(Latest) J:218225 Imig C, et al., The morphological and molecular nature of synaptic vesicle priming at presynaptic active zones. Neuron. 2014 Oct 22;84(2):416-31
All references(115)
Other
accession IDs
MGD-MRK-16452, MGI:2143817

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory