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Syt1
Gene Detail
 Symbol
Name
ID
Syt1
synaptotagmin I
MGI:99667
Synonyms G630098F17Rik
Feature Type protein coding gene
Genetic Map
Chromosome 10
56.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr10:108497650-109010982 bp, - strand
From VEGA annotation of GRCm38

  513333 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4122  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: B/K protein/synaptotagmin
Gene Tree: Syt1

Human
homologs
Human Homolog SYT1, synaptotagmin I
NCBI Gene ID 6857
neXtProt AC  NX_P21579
Human Synonyms  P65, SVP65, SYT
Human Chr (Location)  12cen-q21; chr12:78863993-79452008 (+)  GRCh38
Alleles
and
phenotypes
All alleles(16) : Gene trapped(7) Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice do not suckle, show impaired synaptic transmission and Ca2+-evoked neurotransmitter release, and die by 48 hrs of life. Knock-in mice bearing a missense mutation show enhanced synaptic depression while those carrying a point mutation show reduced synaptic release probability.
 
Gene Ontology
(GO)
classifications
All GO classifications: (55 annotations)
Process detection of calcium ion, neurotransmitter secretion, ...
Component cell, cell junction, ...
Function calcium-dependent phospholipid binding, calcium-dependent protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (741)    Tissues (176)    Images (65)
Theiler Stages: 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 682
Western blot 53
RT-PCR 6
cDNA source data(17)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(25) cDNA(23) Primer pair(2)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000016266 (Evidence)
Ensembl Gene ModelENSMUSG00000035864 (Evidence)
Entrez Gene20979 (Evidence)
DFCITC1576414, TC1598701, TC1602015, TC1621289
DoTSDT.101335131, DT.101390352, DT.482188, DT.94141720, DT.97387564
NIA Mouse Gene IndexU032208
Consensus CDS ProjectCCDS24163.1
International Mouse Knockout Project StatusSyt1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016266 VEGA Gene Model | MGI Sequence Detail 513333 C57BL/6J ±  kb
transcript OTTMUST00000039005 VEGA | MGI Sequence Detail 4820 Not Applicable 
polypeptide OTTMUSP00000017428 VEGA | MGI Sequence Detail 421 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(14) UniProt(4)
Polymorphisms RFLP(2) : SNPs within 2kb(2794 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR001565 Synaptotagmin
InterPro IPR015428 Synaptotagmin 1
Protein Ontology PR:000015894 synaptotagmin-1
References (Earliest) J:18436 Mayanil CS, et al., Synaptic vesicle and synaptic membrane glycoproteins during pre- and postnatal development of mouse cerebral cortex, cerebellum and spinal cord. Dev Neurosci. 1993;15(2):133-45
(Latest) J:193895 Cao P, et al., Complexin activates exocytosis of distinct secretory vesicles controlled by different synaptotagmins. J Neurosci. 2013 Jan 23;33(4):1714-27
All references(106)
Other
accession IDs
MGD-MRK-16452, MGI:2143817

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory