Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes STAP1
  • Mouse genes Stap1
  • Rat genes Stap1
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Stap1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005157	macrophage colony-stimulating factor receptor binding	Stap1	IPI	UniProtKB:P09581	Mouse	MGI:MGI:3831067|PMID:19100238
Molecular Function	GO:0001784	phosphotyrosine residue binding	STAP1	IPI	UniProtKB:Q9GZY6	Human	PMID:20442417
Molecular Function	GO:0005515	protein binding	STAP1	IPI	UniProtKB:Q96B97	Human	PMID:15090612
Molecular Function	GO:0005515	protein binding	STAP1	IPI	UniProtKB:O94763	Human	PMID:17936702
Molecular Function	GO:0005515	protein binding	STAP1	IPI	UniProtKB:Q96B97	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	STAP1	IPI	UniProtKB:P08581	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	STAP1	IPI	UniProtKB:P10275	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	STAP1	IPI	UniProtKB:P10721	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	STAP1	IPI	UniProtKB:Q13480	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	STAP1	IPI	UniProtKB:Q5JPT6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	STAP1	IPI	UniProtKB:Q86VR2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	STAP1	IPI	UniProtKB:Q96B97	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	STAP1	IPI	UniProtKB:Q4V328	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	STAP1	IPI	UniProtKB:Q86VR2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Stap1	IPI	PR:P24604	Mouse	PMID:11716489
Molecular Function	GO:0005515	protein binding	Stap1	IPI	PR:P05532	Mouse	PMID:10679268
Molecular Function	GO:0019901	protein kinase binding	STAP1	IPI	UniProtKB:P42680	Human	PMID:10518561
Molecular Function	GO:0030296	protein tyrosine kinase activator activity	STAP1	IDA		Human	PMID:10518561
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	Stap1	IDA		Mouse	PMID:10679268
Molecular Function	GO:0030971	receptor tyrosine kinase binding	Stap1	IPI	UniProtKB:P09581	Mouse	MGI:MGI:3831067|PMID:19100238
Molecular Function	GO:0035591	signaling adaptor activity	STAP1	IPI	UniProtKB:P42680	Human	PMID:10518561
Molecular Function	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	Stap1	IDA		Mouse	MGI:MGI:3831067|PMID:19100238
Cellular Component	GO:0034451	centriolar satellite	STAP1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005737	cytoplasm	STAP1	IDA		Human	PMID:17936702
Cellular Component	GO:0005829	cytosol	STAP1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	STAP1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	STAP1	IDA		Human	PMID:17936702
Cellular Component	GO:0005654	nucleoplasm	STAP1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	STAP1	IDA		Human	PMID:17936702
Cellular Component	GO:0032991	protein-containing complex	STAP1	IDA		Human	PMID:18468998
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Stap1	IDA		Mouse	MGI:MGI:3831067|PMID:19100238
Biological Process	GO:0010760	negative regulation of macrophage chemotaxis	Stap1	IMP		Mouse	MGI:MGI:3831067|PMID:19100238
Biological Process	GO:1902227	negative regulation of macrophage colony-stimulating factor signaling pathway	Stap1	IMP		Mouse	MGI:MGI:3831067|PMID:19100238
Biological Process	GO:1904140	negative regulation of microglial cell migration	Stap1	IMP		Mouse	MGI:MGI:3831067|PMID:19100238
Biological Process	GO:0042326	negative regulation of phosphorylation	Stap1	IDA		Mouse	MGI:MGI:3831067|PMID:19100238
Biological Process	GO:1900028	negative regulation of ruffle assembly	Stap1	IMP		Mouse	MGI:MGI:3831067|PMID:19100238
Biological Process	GO:2000251	positive regulation of actin cytoskeleton reorganization	Stap1	IMP		Mouse	MGI:MGI:3831067|PMID:19100238
Biological Process	GO:0050861	positive regulation of B cell receptor signaling pathway	STAP1	IDA		Human	PMID:10518561
Biological Process	GO:0010628	positive regulation of gene expression	Stap1	IDA		Mouse	MGI:MGI:3831067|PMID:19100238
Biological Process	GO:1903980	positive regulation of microglial cell activation	Stap1	IMP		Mouse	MGI:MGI:3831067|PMID:19100238
Biological Process	GO:1904151	positive regulation of microglial cell mediated cytotoxicity	Stap1	IDA		Mouse	MGI:MGI:3831067|PMID:19100238
Biological Process	GO:0060100	positive regulation of phagocytosis, engulfment	Stap1	IDA		Mouse	MGI:MGI:3831067|PMID:19100238
Biological Process	GO:0009617	response to bacterium	Stap1	IEP		Mouse	PMID:23012479
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	Stap1	IDA		Mouse	MGI:MGI:3831067|PMID:19100238
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	Stap1	IDA		Mouse	PMID:10679268

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern