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Stap1
Gene Detail
 Symbol
Name
ID
Stap1
signal transducing adaptor family member 1
MGI:1926193
Synonyms Brdg1, STAP-1
Feature Type protein coding gene
Genetic Map
Chromosome 5
43.56 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr5:86071746-86103993 bp, + strand
From VEGA annotation of GRCm38

  32248 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8103  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Stap1

Human
homologs
Human Homolog STAP1, signal transducing adaptor family member 1
NCBI Gene ID 26228
neXtProt AC  NX_Q9ULZ2
Human Synonyms  BRDG1, STAP-1
Human Chr (Location)  4q13.2; chr4:67558728-67607341 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Stap1 interacts with 73 markers (Mir17, Mir20a, Mir20b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process myeloid cell differentiation, positive regulation of signal transduction, ...
Component cytoplasm, mitochondrion, ...
Function protein binding, SH3/SH2 adaptor activity
External Resources: FuncBase
Expression
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(12)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000022745 (Evidence)
Ensembl Gene ModelENSMUSG00000029254 (Evidence)
Entrez Gene56792 (Evidence)
UniGene131237
DFCITC1586434, TC1593195
DoTSDT.40170714, DT.87070274, DT.91563321
NIA Mouse Gene IndexU005734
Consensus CDS ProjectCCDS19377.1
International Mouse Knockout Project StatusStap1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022745 VEGA Gene Model | MGI Sequence Detail 32248 C57BL/6J ±  kb
transcript OTTMUST00000054587 VEGA | MGI Sequence Detail 1218 Not Applicable 
polypeptide OTTMUSP00000026072 VEGA | MGI Sequence Detail 297 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(8) UniProt(2)
Polymorphisms SNPs within 2kb(176 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR000980 SH2 domain
Protein Ontology PR:000015713 signal-transducing adaptor protein 1
References (Earliest) J:64951 Masuhara M, et al., Molecular cloning of murine STAP-1, the stem-cell-specific adaptor protein containing PH and SH2 domains. Biochem Biophys Res Commun. 2000 Feb 24;268(3):697-703
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(32)
Other
accession IDs
MGI:2140935

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory