Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SRI
  • Mouse genes Sri
  • Rat genes Sri
  • Zfish genes sri
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sri

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	SRI	IDA		Human	PMID:17215369
Molecular Function	GO:0140297	DNA-binding transcription factor binding	Sri	IPI	UniProtKB:Q99MZ3	Mouse	MGI:MGI:5487506|PMID:22338092
Molecular Function	GO:0002020	protease binding	SRI	IPI	UniProtKB:P49810	Human	PMID:10748169
Molecular Function	GO:0005515	protein binding	SRI	IPI	UniProtKB:Q13137	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	SRI	IPI	UniProtKB:P40763	Human	PMID:18330356
Molecular Function	GO:0005515	protein binding	SRI	IPI	UniProtKB:Q13137	Human	PMID:18330356
Molecular Function	GO:0005515	protein binding	SRI	IPI	UniProtKB:P40763	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	SRI	IPI	UniProtKB:Q08493-3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SRI	IPI	UniProtKB:Q13137	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SRI	IPI	UniProtKB:Q99081	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SRI	IPI	UniProtKB:Q9NZ81	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SRI	IPI	UniProtKB:Q08493-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SRI	IPI	UniProtKB:Q8N6Y0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SRI	IPI	UniProtKB:P20073	Human	PMID:9268363
Molecular Function	GO:0005515	protein binding	SRI	IPI	UniProtKB:P50995	Human	PMID:9268363
Molecular Function	GO:0005515	protein binding	Sri	IPI	PR:Q07076	Mouse	PMID:14644162
Molecular Function	GO:0005515	protein binding	Sri	IPI	PR:Q61144	Mouse	PMID:16204356
Molecular Function	GO:0046982	protein heterodimerization activity	SRI	IPI	UniProtKB:P28676	Human	PMID:12804766
Cellular Component	GO:0030424	axon	Sri	IDA		Rat	PMID:10188938|RGD:7327208
Cellular Component	GO:0043679	axon terminus	Sri	IDA		Rat	PMID:10188938|RGD:7327208
Cellular Component	GO:0042584	chromaffin granule membrane	SRI	IDA		Human	PMID:9268363
Cellular Component	GO:0005829	cytosol	SRI	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	SRI	IDA		Human	PMID:10748169
Cellular Component	GO:0005829	cytosol	Sri	IDA		Rat	PMID:16931553|RGD:7327199
Cellular Component	GO:0044326	dendritic spine neck	Sri	IDA		Rat	PMID:10188938|RGD:7327208
Cellular Component	GO:0005789	endoplasmic reticulum membrane	SRI	IDA		Human	PMID:10672515
Cellular Component	GO:0070062	extracellular exosome	SRI	IDA		Human	PMID:15326289
Cellular Component	GO:0070062	extracellular exosome	SRI	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	SRI	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	SRI	HDA		Human	PMID:23533145
Cellular Component	GO:0005622	intracellular anatomical structure	Sri	IDA		Mouse	PMID:14644162
Cellular Component	GO:0016020	membrane	SRI	IDA		Human	PMID:10748169
Cellular Component	GO:0016020	membrane	SRI	IDA		Human	PMID:17130302
Cellular Component	GO:0005739	mitochondrion	Sri	IDA		Rat	PMID:9378856|RGD:7327212
Cellular Component	GO:0005654	nucleoplasm	SRI	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	Sri	IDA		Mouse	PMID:14644162
Cellular Component	GO:0005886	plasma membrane	Sri	IDA		Rat	PMID:10188938|RGD:7327208
Cellular Component	GO:0005790	smooth endoplasmic reticulum	Sri	IDA		Rat	PMID:9378856|RGD:7327212
Cellular Component	GO:0030315	T-tubule	Sri	IDA		Rat	PMID:16931553|RGD:7327199
Cellular Component	GO:0031982	vesicle	Sri	IDA		Mouse	PMID:12925238
Cellular Component	GO:0030018	Z disc	SRI	IDA		Human	PMID:12754254
Cellular Component	GO:0030018	Z disc	Sri	IDA		Mouse	MGI:MGI:3784084|PMID:12754254
Cellular Component	GO:0030018	Z disc	Sri	IDA		Mouse	PMID:16204356
Cellular Component	GO:0030018	Z disc	Sri	IDA		Rat	PMID:12754254|RGD:7327200
Biological Process	GO:0006816	calcium ion transport	Sri	IPI	PR:Q61144	Mouse	PMID:16204356
Biological Process	GO:0042994	cytoplasmic sequestering of transcription factor	Sri	IMP		Mouse	MGI:MGI:5487506|PMID:22338092
Biological Process	GO:0007507	heart development	Sri	IEP		Rat	PMID:9668070|RGD:7327211
Biological Process	GO:0055118	negative regulation of cardiac muscle contraction	Sri	IMP		Mouse	MGI:MGI:5319286|PMID:22326846
Biological Process	GO:0010459	negative regulation of heart rate	SRI	IMP		Human	PMID:12754254
Biological Process	GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity	SRI	IDA		Human	PMID:17699613
Biological Process	GO:2000678	negative regulation of transcription regulatory region DNA binding	Sri	IMP		Mouse	MGI:MGI:5487506|PMID:22338092
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	Sri	IMP		Mouse	MGI:MGI:5487506|PMID:22338092
Biological Process	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	Sri	IMP		Mouse	MGI:MGI:5487506|PMID:22338092
Biological Process	GO:0051924	regulation of calcium ion transport	SRI	IMP		Human	PMID:12754254
Biological Process	GO:0051924	regulation of calcium ion transport	SRI	IMP		Human	PMID:17130302
Biological Process	GO:0086004	regulation of cardiac muscle cell contraction	SRI	IMP		Human	PMID:12754254
Biological Process	GO:0086004	regulation of cardiac muscle cell contraction	SRI	IMP		Human	PMID:17130302
Biological Process	GO:1901844	regulation of cell communication by electrical coupling involved in cardiac conduction	SRI	IMP		Human	PMID:17130302
Biological Process	GO:1901841	regulation of high voltage-gated calcium channel activity	SRI	IMP		Human	PMID:12754254
Biological Process	GO:1901077	regulation of relaxation of muscle	SRI	IMP		Human	PMID:12754254

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern