Sri MGI Mouse Gene Detail - MGI:98419

Symbol

Sri
Name

sorcin
Synonyms

2210417O06Rik, 2900070H08Rik, Sor

Feature Type

protein coding gene
IDs

MGI:98419
NCBI Gene: 109552
Gene Overview

MyGene.info: SRI
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr5:8046078-8069314 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 3.38 cM, cytoband A1
Mapping Data

5 experiments

SNPs within 2kb

215 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98419	protein coding gene	Chr5:8046078-8069379 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029280	protein coding gene	Chr5:5008670-5031499 (+)
A/J	MGP_AJ_G0029244	protein coding gene	Chr5:4847467-4871906 (+)
AKR/J	MGP_AKRJ_G0029193	protein coding gene	Chr5:4969527-4994529 (+)
BALB/cJ	MGP_BALBcJ_G0029261	protein coding gene	Chr5:5066947-5090771 (+)
C3H/HeJ	MGP_C3HHeJ_G0028981	protein coding gene	Chr5:5171642-5195934 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029711	protein coding gene	Chr5:5493760-5519762 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026954	protein coding gene	Chr5:4678345-4701543 (+)
CAST/EiJ	MGP_CASTEiJ_G0028394	protein coding gene	Chr5:5041946-5065453 (+)
CBA/J	MGP_CBAJ_G0028942	protein coding gene	Chr5:5617629-5645820 (+)
DBA/2J	MGP_DBA2J_G0029096	protein coding gene	Chr5:4979821-5003145 (+)
FVB/NJ	MGP_FVBNJ_G0029056	protein coding gene	Chr5:4773927-4796961 (+)
LP/J	MGP_LPJ_G0029185	protein coding gene	Chr5:5134187-5157730 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029083	protein coding gene	Chr5:5611201-5633755 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029742	protein coding gene	Chr5:4989951-5013220 (+)
PWK/PhJ	MGP_PWKPhJ_G0028116	protein coding gene	Chr5:4781326-4804815 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027949	protein coding gene	Chr5:5176360-5199162 (+)
WSB/EiJ	MGP_WSBEiJ_G0028474	protein coding gene	Chr5:4980592-5003427 (+)

Human Ortholog

SRI, sorcin

Vertebrate Orthologs

10

Human Ortholog

SRI, sorcin
Orthology source: HomoloGene, HGNC
Synonyms

CP22, CP-22, SCN, V19
Links

HGNC:11292

NCBI Gene ID: 6717

neXtProt AC: NX_P30626

UniProt: P30626
Chr Location

7q21.12; chr7:88205115-88226993 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 37736
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: SRI
Protein SuperFamily

sorcin-like protein
Gene Tree

Sri

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Phenotype Summary

8 phenotypes from 3 alleles in 2 genetic backgrounds
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Gene trapped

1
Targeted

2
Transgenic

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozgyous for a knock-out allele exhibit impaired glucose tolerance and decreased circulating insulin levels.

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All GO Annotations

43
GO References

9

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

631
cDNA Data

17

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sri

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Sri interacts with 259 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

61
RefSeq

8
UniProt

1
CCDS

CCDS19079.1, CCDS39009.1

Ensembl

ENSMUSG00000003161 (Evidence)
NCBI Gene

109552

			Length	Strain/Species	Flank
genomic	109552	NCBI Gene Model \| MGI Sequence Detail	23237	C57BL/6J	± kb
transcript	NM_025618	RefSeq \| MGI Sequence Detail	2439	C57BL/6
polypeptide	Q6P069	UniProt \| EBI \| MGI Sequence Detail	198	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000015619 sorcin

(term hierarchy)
InterPro Domains

IPR018247 EF-Hand 1, calcium-binding site

IPR002048 EF-hand domain

IPR011992 EF-hand domain pair

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All nucleic 19

cDNA 18

Other 1

Microarray probesets 7

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MGD-MRK-14488, MGD-MRK-14598, MGI:1913777, MGI:1920275

Summaries

All 39

Gene Ontology 9

Phenotypes 5
Earliest

J:2349 Dernoncourt C, et al., Estimation of genetic distances between reeler and nearby loci on mouse chromosome 5. Genomics. 1991 Dec;11(4):1167-9
Latest

J:257038 Chen X, et al., Sorcin ablation plus beta-adrenergic stimulation generate an arrhythmogenic substrate in mouse ventricular myocytes. J Mol Cell Cardiol. 2018 Jan;114:199-210

TSS for Sri:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr45103	Chr5:8046077-8046078 (+)	0 bp
Tssr45104	Chr5:8046122-8046152 (+)	59 bp
Tssr45105	Chr5:8046162-8046184 (+)	95 bp
Tssr45107	Chr5:8056536-8056551 (+)	10,466 bp
Tssr45108	Chr5:8056555-8056585 (+)	10,492 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 02/23/2021 MGI 6.16