Sri MGI Mouse Gene Detail - MGI:98419

Symbol

Sri
Name

sorcin
Synonyms

2210417O06Rik, 2900070H08Rik, Sor

Feature Type

protein coding gene
IDs

MGI:98419
NCBI Gene: 109552
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr5:8096078-8119314 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 3.38 cM, cytoband A1
Mapping Data

5 experiments

SNPs within 2kb

888 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98419	protein coding gene	Chr5:8096078-8119379 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029280	protein coding gene	Chr5:5008670-5031499 (+)
A/J	MGP_AJ_G0029244	protein coding gene	Chr5:4847467-4871906 (+)
AKR/J	MGP_AKRJ_G0029193	protein coding gene	Chr5:4969527-4994529 (+)
BALB/cJ	MGP_BALBcJ_G0029261	protein coding gene	Chr5:5066947-5090771 (+)
C3H/HeJ	MGP_C3HHeJ_G0028981	protein coding gene	Chr5:5171642-5195934 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029711	protein coding gene	Chr5:5493760-5519762 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026954	protein coding gene	Chr5:4678345-4701543 (+)
CAST/EiJ	MGP_CASTEiJ_G0028394	protein coding gene	Chr5:5041946-5065453 (+)
CBA/J	MGP_CBAJ_G0028942	protein coding gene	Chr5:5617629-5645820 (+)
DBA/2J	MGP_DBA2J_G0029096	protein coding gene	Chr5:4979821-5003145 (+)
FVB/NJ	MGP_FVBNJ_G0029056	protein coding gene	Chr5:4773927-4796961 (+)
LP/J	MGP_LPJ_G0029185	protein coding gene	Chr5:5134187-5157730 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029083	protein coding gene	Chr5:5611201-5633755 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029742	protein coding gene	Chr5:4989951-5013220 (+)
PWK/PhJ	MGP_PWKPhJ_G0028116	protein coding gene	Chr5:4781326-4804815 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027949	protein coding gene	Chr5:5176360-5199162 (+)
WSB/EiJ	MGP_WSBEiJ_G0028474	protein coding gene	Chr5:4980592-5003427 (+)

Human Ortholog

SRI, sorcin

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SRI, sorcin
Synonyms

CP-22, CP22, SCN, V19
Links

HGNC:11292

NCBI Gene ID: 6717

UniProt: P30626
Chr Location

7q21.12; chr7:88205115-88226993 (-) GRCh38

MGI Vertebrate Homology

Sri stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: SRI
Gene Tree

Sri

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Phenotype Summary

8 phenotypes from 3 alleles in 2 genetic backgrounds
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

4
Gene trapped

1
Targeted

2
Transgenic

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozgyous for a knock-out allele exhibit impaired glucose tolerance and decreased circulating insulin levels.

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All GO Annotations

60
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

17

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sri

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All Sequences

62
RefSeq

8
UniProt

1
CCDS

CCDS19079.1, CCDS39009.1

Ensembl

ENSMUSG00000003161 (Evidence)
NCBI Gene

109552

			Length	Strain/Species	Flank
genomic	109552	NCBI Gene Model \| MGI Sequence Detail	23237	C57BL/6J	± kb
transcript	NM_025618	RefSeq \| MGI Sequence Detail	2439	ZRU/MplStud
polypeptide	Q6P069	UniProt \| EBI \| MGI Sequence Detail	198	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000015619 sorcin

(term hierarchy)
InterPro Domains

IPR018247 EF-Hand 1, calcium-binding site

IPR002048 EF-hand domain

IPR011992 EF-hand domain pair

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All nucleic 19

cDNA 18

Other 1

Microarray probesets 7

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MGD-MRK-14488, MGD-MRK-14598, MGI:1913777, MGI:1920275

Summaries

All 47

Gene Ontology 14

Phenotypes 8
Earliest

J:2349 Dernoncourt C, et al., Estimation of genetic distances between reeler and nearby loci on mouse chromosome 5. Genomics. 1991 Dec;11(4):1167-9
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Sri:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr45103	Chr5:8096077-8096078 (+)	0 bp
Tssr45104	Chr5:8096122-8096152 (+)	59 bp
Tssr45105	Chr5:8096162-8096184 (+)	95 bp
Tssr45107	Chr5:8106536-8106551 (+)	10,466 bp
Tssr45108	Chr5:8106555-8106585 (+)	10,492 bp
Tssr45109	Chr5:8115119-8115135 (+)	19,049 bp
Tssr45110	Chr5:8115183-8115194 (+)	19,111 bp
Tssr45111	Chr5:8115197-8115254 (+)	19,148 bp
Tssr45112	Chr5:8117629-8117652 (+)	21,563 bp
Tssr45113	Chr5:8118424-8118440 (+)	22,354 bp
Tssr45114	Chr5:8118443-8118463 (+)	22,375 bp
Tssr45115	Chr5:8118656-8118678 (+)	22,589 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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