Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SPRY4
  • Mouse genes Spry4
  • Rat genes Spry4
  • Zfish genes spry4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Spry4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	SPRY4	IPI	UniProtKB:Q15569	Human	PMID:12027893
Molecular Function	GO:0005515	protein binding	SPRY4	IPI	UniProtKB:Q15569	Human	PMID:15584898
Molecular Function	GO:0005515	protein binding	SPRY4	IPI	UniProtKB:P22681	Human	PMID:18273061
Molecular Function	GO:0005515	protein binding	SPRY4	IPI	UniProtKB:Q8IUH5	Human	PMID:24705354
Molecular Function	GO:0005515	protein binding	SPRY4	IPI	UniProtKB:O43184-4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPRY4	IPI	UniProtKB:O95231	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPRY4	IPI	UniProtKB:O95967	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPRY4	IPI	UniProtKB:P27658	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPRY4	IPI	UniProtKB:P32242	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPRY4	IPI	UniProtKB:P49639	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPRY4	IPI	UniProtKB:P61970	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPRY4	IPI	UniProtKB:Q02930-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPRY4	IPI	UniProtKB:Q12837	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPRY4	IPI	UniProtKB:Q14192	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPRY4	IPI	UniProtKB:Q2WGJ6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPRY4	IPI	UniProtKB:Q6L8G4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPRY4	IPI	UniProtKB:D3DTS7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPRY4	IPI	UniProtKB:G5E9A7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPRY4	IPI	UniProtKB:O60260-5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPRY4	IPI	UniProtKB:O60333-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPRY4	IPI	UniProtKB:O75400-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPRY4	IPI	UniProtKB:O76024	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPRY4	IPI	UniProtKB:P02489	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPRY4	IPI	UniProtKB:P02766	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPRY4	IPI	UniProtKB:P04792	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPRY4	IPI	UniProtKB:P06307	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPRY4	IPI	UniProtKB:P06396	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPRY4	IPI	UniProtKB:P07339	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPRY4	IPI	UniProtKB:P13473-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPRY4	IPI	UniProtKB:P22607	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPRY4	IPI	UniProtKB:P28329-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPRY4	IPI	UniProtKB:P28799	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPRY4	IPI	UniProtKB:P31948	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPRY4	IPI	UniProtKB:P55212	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPRY4	IPI	UniProtKB:P60891	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPRY4	IPI	UniProtKB:P62826	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPRY4	IPI	UniProtKB:Q7Z699	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPRY4	IPI	UniProtKB:Q86V38	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPRY4	IPI	UniProtKB:Q8NI60	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPRY4	IPI	UniProtKB:Q92876	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPRY4	IPI	UniProtKB:Q9UMX0	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SPRY4	IPI	UniProtKB:Q9Y3C5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Spry4	IPI	UniProtKB:Q63572	Mouse	MGI:MGI:3771987|PMID:17974561
Molecular Function	GO:0005515	protein binding	Spry4	IPI	UniProtKB:P49817	Mouse	MGI:MGI:3695236|PMID:16877379
Molecular Function	GO:0005515	protein binding	Spry4	IPI	PR:Q9QXV9	Mouse	PMID:16339969
Molecular Function	GO:0005515	protein binding	Spry4	IPI	PR:Q9QXV8	Mouse	PMID:16339969
Molecular Function	GO:0005515	protein binding	Spry4	IPI	MGI:MGI:1345188	Mouse	PMID:16339969
Molecular Function	GO:0005515	protein binding	Spry4	IPI	PR:Q62245	Mouse	PMID:16339969
Molecular Function	GO:0005515	protein binding	Spry4	IPI	PR:Q9WTP2	Mouse	PMID:16339969
Molecular Function	GO:0004860	protein kinase inhibitor activity	SPRY4	IMP		Human	PMID:15584898
Cellular Component	GO:0005737	cytoplasm	SPRY4	IDA		Human	PMID:15584898
Cellular Component	GO:0005925	focal adhesion	SPRY4	HDA		Human	PMID:21423176
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	Spry4	IEP		Mouse	PMID:20439489
Biological Process	GO:0030097	hemopoiesis	spry4	IMP	ZFIN:ZDB-MRPHLNO-060601-7	Zfish	PMID:16089502
Biological Process	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway	spry4	IMP		Zfish	PMID:11520667
Biological Process	GO:0043407	negative regulation of MAP kinase activity	Spry4	IDA		Mouse	PMID:16339969
Biological Process	GO:1900025	negative regulation of substrate adhesion-dependent cell spreading	SPRY4	IMP		Human	PMID:15584898
Biological Process	GO:0040036	regulation of fibroblast growth factor receptor signaling pathway	spry4	IMP	ZFIN:ZDB-MRPHLNO-070627-2	Zfish	PMID:21177344
Biological Process	GO:0021594	rhombomere formation	spry4	IMP	ZFIN:ZDB-MRPHLNO-070627-2	Zfish	PMID:21177344
Biological Process	GO:0048741	skeletal muscle fiber development	spry4	IMP	ZFIN:ZDB-GENO-140530-2	Zfish	PMID:23133395

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern