Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SPR
  • Mouse genes Spr
  • Rat genes Spr,Spr-ps1
  • Zfish genes spra,sprb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Spr

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042803	protein homodimerization activity	Spr	IPI	UniProtKB:Q64105	Mouse	MGI:MGI:1101678|PMID:9405351
Molecular Function	GO:0004757	sepiapterin reductase activity	Spr	IDA		Rat	PMID:10350607|RGD:8554741
Molecular Function	GO:0004757	sepiapterin reductase activity	Spr	IDA		Rat	PMID:2179471|RGD:1600056
Molecular Function	GO:0004757	sepiapterin reductase activity	Spr	IDA		Rat	PMID:2201030|RGD:70022
Cellular Component	GO:0005829	cytosol	SPR	IDA		Human	GO_REF:0000052
Cellular Component	GO:0070062	extracellular exosome	SPR	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	SPR	HDA		Human	PMID:23533145
Cellular Component	GO:0005739	mitochondrion	Spr	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005654	nucleoplasm	SPR	IDA		Human	GO_REF:0000052
Biological Process	GO:0048667	cell morphogenesis involved in neuron differentiation	Spr	IMP	MGI:MGI:3757641	Mouse	PMID:16532389
Biological Process	GO:0042417	dopamine metabolic process	Spr	IMP	MGI:MGI:3757641	Mouse	PMID:16532389
Biological Process	GO:0006558	L-phenylalanine metabolic process	Spr	IMP	MGI:MGI:3757641	Mouse	PMID:16532389
Biological Process	GO:0006809	nitric oxide biosynthetic process	SPR	IDA		Human	PMID:15197144
Biological Process	GO:0042415	norepinephrine metabolic process	Spr	IMP	MGI:MGI:3757641	Mouse	PMID:16532389
Biological Process	GO:0019889	pteridine metabolic process	Spr	IMP	MGI:MGI:3757641	Mouse	PMID:16532389
Biological Process	GO:0040014	regulation of multicellular organism growth	Spr	IMP	MGI:MGI:3757641	Mouse	PMID:16532389
Biological Process	GO:0010033	response to organic substance	Spr	IMP		Rat	PMID:12604243|RGD:1600055
Biological Process	GO:0042428	serotonin metabolic process	Spr	IMP	MGI:MGI:3757641	Mouse	PMID:16532389
Biological Process	GO:0006729	tetrahydrobiopterin biosynthetic process	Spr	IMP		Rat	PMID:2179471|RGD:1600056
Biological Process	GO:0046146	tetrahydrobiopterin metabolic process	Spr	IMP	MGI:MGI:3757641	Mouse	PMID:16532389
Biological Process	GO:0050882	voluntary musculoskeletal movement	Spr	IMP	MGI:MGI:3757641	Mouse	PMID:16532389

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern