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Spr
Gene Detail
 Symbol
Name
ID
Spr
sepiapterin reductase
MGI:103078
Feature Type protein coding gene
Genetic Map
Chromosome 6
37.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:85133678-85137766 bp, - strand
From VEGA annotation of GRCm38

  4089 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37735  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Spr

Human
homologs
Human Homolog SPR, sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
NCBI Gene ID 6697
neXtProt AC  NX_P35270
Human Synonyms  SDR38C1
Human Chr (Location)  2p14-p12; chr2:72887383-72892160 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human SPR
Alleles
and
phenotypes
All alleles(4) : Targeted(4)
 
Mice homozygous for a null allele exhibit premature death, severe growth retardation, dwarfism, decreased levels of insulin-like growth factor 1, dopamine, serotonine, noradrenaline, biopterin, and neopterin, abnormal voluntary movement, and elevated phenylalanine levels.
 
Human Diseases Modeled Using Mouse Spr (2)    Alleles Annotated to Human Diseases(2)   
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process cell morphogenesis involved in neuron differentiation, death, ...
Component cytoplasm, extracellular vesicular exosome, ...
Function oxidoreductase activity, protein homodimerization activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Images (7)
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(96)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(98) cDNA(96) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000037795 (Evidence)
Ensembl Gene ModelENSMUSG00000033735 (Evidence)
Entrez Gene20751 (Evidence)
UniGene28393
DFCITC1576059
DoTSDT.535565, DT.94333811, DT.99850241
NIA Mouse Gene IndexU027547, U277677
EC1.1.1.153
PDB1NAS, 1OAA, 1SEP
Consensus CDS ProjectCCDS51826.1
International Mouse Knockout Project StatusSpr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037795 VEGA Gene Model | MGI Sequence Detail 4089 C57BL/6J ±  kb
transcript OTTMUST00000097538 VEGA | MGI Sequence Detail 1230 Not Applicable 
polypeptide OTTMUSP00000054720 VEGA | MGI Sequence Detail 262 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(2) UniProt(5)
Polymorphisms PCR(1) : SNPs within 2kb(30 from dbSNP Build 137)    SNPs within 2kb including multiple locations(40)
Protein-related
information
ResourceIDDescription
InterPro IPR002347 Glucose/ribitol dehydrogenase
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR006393 Sepiapterin reductase
InterPro IPR002198 Short-chain dehydrogenase/reductase SDR
Protein Ontology PR:000015567 sepiapterin reductase
References (Earliest) J:23125 Ota A, et al., Mouse sepiapterin reductase: an enzyme involved in the final step of tetrahydrobiopterin biosynthesis. Primary structure deduced from the cDNA sequence. Biochim Biophys Acta. 1995 Feb 21;1260(3):320-2
(Latest) J:199933 Kwak SS, et al., Amelioration of Behavioral Abnormalities in BH4-deficient Mice by Dietary Supplementation of Tyrosine. PLoS One. 2013;8(4):e60803
All references(42)
Other
accession IDs
MGD-MRK-23942, MGI:2141365

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory