Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SPINT2
  • Mouse genes Spint2
  • Rat genes Spint2
  • Zfish genes spint2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Spint2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	SPINT2	IDA		Human	PMID:19185281
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	SPINT2	IDA		Human	PMID:25301953
Cellular Component	GO:0005737	cytoplasm	SPINT2	IDA		Human	PMID:11606055
Cellular Component	GO:0005886	plasma membrane	Spint2	IDA		Rat	PMID:23409135|RGD:10043095
Biological Process	GO:0071711	basement membrane organization	Spint2	IMP	MGI:MGI:2156187	Mouse	PMID:19592578
Biological Process	GO:0071773	cellular response to BMP stimulus	Spint2	IEP		Rat	PMID:23409135|RGD:10043095
Biological Process	GO:0060672	epithelial cell morphogenesis involved in placental branching	Spint2	IGI	MGI:MGI:1338881	Mouse	PMID:19592578
Biological Process	GO:0060672	epithelial cell morphogenesis involved in placental branching	Spint2	IMP	MGI:MGI:2156187	Mouse	PMID:19592578
Biological Process	GO:0007163	establishment or maintenance of cell polarity	Spint2	IMP	MGI:MGI:2156187	Mouse	PMID:19592578
Biological Process	GO:2000146	negative regulation of cell motility	SPINT2	IDA		Human	PMID:19592578
Biological Process	GO:0022408	negative regulation of cell-cell adhesion	SPINT2	IDA		Human	PMID:19592578
Biological Process	GO:2000178	negative regulation of neural precursor cell proliferation	Spint2	IMP		Rat	PMID:23409135|RGD:10043095
Biological Process	GO:0001843	neural tube closure	Spint2	IGI	MGI:MGI:1338033	Mouse	PMID:19592578
Biological Process	GO:0001843	neural tube closure	Spint2	IMP	MGI:MGI:2156187	Mouse	PMID:19592578
Biological Process	GO:0001843	neural tube closure	Spint2	IGI	MGI:MGI:1338881	Mouse	PMID:19592578

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern