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Spint2
Gene Detail
Symbol

Name
ID
Spint2
serine protease inhibitor, Kunitz type 2
MGI:1338031
Synonyms
HAI-2
Feature Type
protein coding gene
Genetic Map
Chromosome 7
16.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:29256331-29281977 bp, - strand
From Ensembl annotation of GRCm38

  25647 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7955  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Spint2

Human
homologs
Human Homolog SPINT2, serine peptidase inhibitor, Kunitz type, 2
NCBI Gene ID 10653
neXtProt AC  NX_O43291
Human Synonyms  DIAR3, HAI2, HAI-2, Kop, PB
Human Chr (Location)  19q13.1; chr19:38264458-38292614 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human SPINT2
Mutations,
alleles, and
phenotypes
All mutations/alleles(33) : Gene trapped(31) Targeted(2)
 
Homozygous embryos carrying an insertional mutation fail to progress to the headfold stage and die at gastrulation displaying a severe clefting of the embryonic ectoderm at E7.5.
 
Interactions
Spint2 interacts with 31 markers (Mir26a-2, Mir29a, Mir30a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (10 records)
Data Summary: Results (393)    Tissues (133)    Images (34)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 348
RT-PCR 45
cDNA source data(422)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(425) Genomic(1) cDNA(422) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000074227 (Evidence)
Entrez Gene20733 (Evidence)
UniGene295230
DFCITC1586959, TC1591954, TC1571927
DoTSDT.97411928, DT.94382077, DT.111010354, DT.102541289, DT.537668, DT.101274220
NIA Mouse Gene IndexU028351
Consensus CDS ProjectCCDS39869.1, CCDS39870.1
International Mouse Knockout Project StatusSpint2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000074227 Ensembl Gene Model | MGI Sequence Detail 25647 C57BL/6J ±  kb
transcript ENSMUST00000098604 Ensembl | MGI Sequence Detail 1459 Not Applicable 
polypeptide ENSMUSP00000096204 Ensembl | MGI Sequence Detail 252 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(6) UniProt(3)
Polymorphisms
SNPs within 2kb(125 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020901 Proteinase inhibitor I2, Kunitz, conserved site
InterPro IPR002223 Proteinase inhibitor I2, Kunitz metazoa
Protein Ontology PR:000015543 kunitz-type protease inhibitor 2
References
(Earliest) J:53204 Itoh H, et al., Hepatocyte growth factor activator inhibitor type 2 lacking the first Kunitz-type serine proteinase inhibitor domain is a predominant product in mouse but not in human. Biochem Biophys Res Commun. 1999 Feb 24;255(3):740-8
(Latest) J:188121 Szabo R, et al., Reduced Prostasin (CAP1/PRSS8) Activity Eliminates HAI-1 and HAI-2 Deficiency-Associated Developmental Defects by Preventing Matriptase Activation. PLoS Genet. 2012 Aug;8(8):e1002937
All references(47)
Other
accession IDs
MGI:2142094, MGI:2142304

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory