Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SPEN
  • Mouse genes Spen
  • Rat genes Spen
  • Zfish genes spen
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Spen

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Spen	IDA		Mouse	PMID:10451362
Molecular Function	GO:0005515	protein binding	SPEN	IPI	UniProtKB:Q04360	Human	PMID:16129689
Molecular Function	GO:0005515	protein binding	SPEN	IPI	UniProtKB:Q9Y618	Human	PMID:16129689
Molecular Function	GO:0005515	protein binding	SPEN	IPI	UniProtKB:Q99708	Human	PMID:16287852
Molecular Function	GO:0005515	protein binding	SPEN	IPI	UniProtKB:P16333	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	SPEN	IPI	UniProtKB:P46108	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	SPEN	IPI	UniProtKB:Q06330	Human	PMID:21102556
Molecular Function	GO:0005515	protein binding	SPEN	IPI	UniProtKB:Q9Y618	Human	PMID:24268649
Molecular Function	GO:0005515	protein binding	SPEN	IPI	UniProtKB:Q06330	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	SPEN	IPI	UniProtKB:P46108	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	Spen	IPI	PR:Q03172	Mouse	PMID:15778499
Molecular Function	GO:0005515	protein binding	Spen	IPI	PR:Q9WU42	Mouse	PMID:15778499
Molecular Function	GO:0005515	protein binding	Spen	IPI	PR:Q03358	Mouse	PMID:10451362
Molecular Function	GO:0003723	RNA binding	SPEN	HDA		Human	PMID:22658674
Molecular Function	GO:0003723	RNA binding	SPEN	HDA		Human	PMID:22681889
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	SPEN	IPI	UniProtKB:Q06330	Human	PMID:16287852
Molecular Function	GO:0003697	single-stranded DNA binding	Spen	IDA		Mouse	PMID:10451362
Molecular Function	GO:0003714	transcription corepressor activity	SPEN	IDA		Human	PMID:16287852
Molecular Function	GO:0003714	transcription corepressor activity	Spen	IDA		Mouse	PMID:15778499
Cellular Component	GO:0070062	extracellular exosome	SPEN	HDA		Human	PMID:19056867
Cellular Component	GO:0005654	nucleoplasm	SPEN	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Spen	IDA		Mouse	PMID:15778499
Cellular Component	GO:0005634	nucleus	Spen	IDA		Mouse	PMID:10451362
Cellular Component	GO:0017053	transcription repressor complex	SPEN	IDA		Human	PMID:16287852
Biological Process	GO:0060047	heart contraction	spen	IMP	ZFIN:ZDB-MRPHLNO-220307-1	Zfish	PMID:33549680
Biological Process	GO:0060047	heart contraction	spen	IGI	ZFIN:ZDB-MRPHLNO-220307-2,ZFIN:ZDB-MRPHLNO-201130-2	Zfish	PMID:33549680
Biological Process	GO:0060047	heart contraction	spen	IMP	ZFIN:ZDB-MRPHLNO-220307-2	Zfish	PMID:33549680
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	SPEN	IDA		Human	PMID:16129689
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Spen	IDA		Mouse	PMID:15778499
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Spen	IDA		Mouse	PMID:10451362
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	SPEN	IDA		Human	PMID:16287852
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Spen	IDA		Mouse	PMID:10451362
Biological Process	GO:0050769	positive regulation of neurogenesis	SPEN	IMP		Human	PMID:16287852

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern