Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SPDEF
  • Mouse genes Spdef
  • Rat genes Spdef
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Spdef

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	SPDEF	IPI	UniProtKB:P20674	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPDEF	IPI	UniProtKB:P25786	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPDEF	IPI	UniProtKB:Q5W5X9-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPDEF	IPI	UniProtKB:Q7Z614-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPDEF	IPI	UniProtKB:Q86XR8-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPDEF	IPI	UniProtKB:Q96MY7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPDEF	IPI	UniProtKB:Q9H0I2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SPDEF	IPI	UniProtKB:Q8WUW1	Human	PMID:32814053
Molecular Function	GO:0043565	sequence-specific DNA binding	SPDEF	IDA		Human	PMID:23332764
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	SPDEF	IDA		Human	PMID:28473536
Cellular Component	GO:0005634	nucleus	Spdef	IDA		Mouse	PMID:17347682
Biological Process	GO:0045165	cell fate commitment	Spdef	IMP	MGI:MGI:4398888	Mouse	PMID:19759516
Biological Process	GO:0072148	epithelial cell fate commitment	Spdef	IMP	MGI:MGI:4398888	Mouse	PMID:19759516
Biological Process	GO:0002068	glandular epithelial cell development	Spdef	IMP	MGI:MGI:4410321	Mouse	PMID:19549527
Biological Process	GO:0060576	intestinal epithelial cell development	Spdef	IMP	MGI:MGI:4410321	Mouse	PMID:19549527
Biological Process	GO:0060480	lung goblet cell differentiation	Spdef	IDA		Mouse	PMID:17347682
Biological Process	GO:0010454	negative regulation of cell fate commitment	Spdef	IMP	MGI:MGI:4398888	Mouse	PMID:19759516
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	SPDEF	IDA		Human	PMID:21656828
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Spdef	IDA		Mouse	PMID:19759516
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Spdef	IMP	MGI:MGI:4410321	Mouse	PMID:19549527
Biological Process	GO:0043065	positive regulation of apoptotic process	SPDEF	IDA		Human	PMID:21656828
Biological Process	GO:0010455	positive regulation of cell fate commitment	Spdef	IMP	MGI:MGI:4398888	Mouse	PMID:19759516
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Spdef	IMP	MGI:MGI:4410321	Mouse	PMID:19549527
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Spdef	IGI	MGI:MGI:108067	Mouse	PMID:17347682
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Spdef	IDA		Mouse	PMID:19759516
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Spdef	IGI	MGI:MGI:1347477	Mouse	PMID:19759516
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Spdef	IDA		Mouse	PMID:17347682
Biological Process	GO:0006366	transcription by RNA polymerase II	Spdef	IDA		Mouse	PMID:19759516
Biological Process	GO:0006366	transcription by RNA polymerase II	Spdef	IGI	MGI:MGI:1347477	Mouse	PMID:19759516
Biological Process	GO:0006366	transcription by RNA polymerase II	Spdef	IMP	MGI:MGI:4410321	Mouse	PMID:19549527

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern