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Spdef Gene Detail
Summary
  • Symbol
    Spdef
  • Name
    SAM pointed domain containing ets transcription factor
  • Synonyms
    PDEF, Pse
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353422
    NCBI Gene: 30051
  • Gene Overview
    MyGene.info: SPDEF
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:27714352-27728951 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 14.59 cM, cytoband B1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    189 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353422
protein coding gene Chr17:27714352-27731003 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023426
protein coding gene Chr17:27040080-27055441 (-)
A/J MGP_AJ_G0023384
protein coding gene Chr17:26179222-26193808 (-)
AKR/J MGP_AKRJ_G0023349
protein coding gene Chr17:26347775-26362361 (-)
BALB/cJ MGP_BALBcJ_G0023389
protein coding gene Chr17:26450596-26465164 (-)
C3H/HeJ MGP_C3HHeJ_G0023150
protein coding gene Chr17:26721730-26736316 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023831
protein coding gene Chr17:28164605-28179204 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021306
protein coding gene Chr17:23562696-23578142 (-)
CAST/EiJ MGP_CASTEiJ_G0022651
protein coding gene Chr17:26686942-26701628 (-)
CBA/J MGP_CBAJ_G0023124
protein coding gene Chr17:29144956-29159528 (-)
DBA/2J MGP_DBA2J_G0023255
protein coding gene Chr17:25740797-25755383 (-)
FVB/NJ MGP_FVBNJ_G0023225
protein coding gene Chr17:25530799-25545385 (-)
LP/J MGP_LPJ_G0023333
protein coding gene Chr17:27306197-27322531 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023243
protein coding gene Chr17:28623442-28639287 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023873
protein coding gene Chr17:26761439-26776038 (-)
PWK/PhJ MGP_PWKPhJ_G0022401
protein coding gene Chr17:24536745-24551443 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022219
protein coding gene Chr17:24766736-24783458 (-)
WSB/EiJ MGP_WSBEiJ_G0022713
protein coding gene Chr17:26747457-26762030 (-)



Homology
more
  • Human Ortholog
    SPDEF, SAM pointed domain containing ETS transcription factor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SPDEF, SAM pointed domain containing ETS transcription factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bA375E1.3, PDEF
  • Links
    NCBI Gene ID: 25803
    neXtProt AC: NX_O95238
    UniProt: O95238

  • Chr Location
    6p21.31; chr6:34537802-34556333 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 3 alleles in 3 genetic backgrounds
    5 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele have reduced numbers of intestinal and respiratory mucosa goblet cells. Increased inflammation of the gastric antrum has also been seen.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024215 Ensembl Gene Model | MGI Sequence Detail 14600 C57BL/6J ±  kb
    transcript ENSMUST00000025054 Ensembl | MGI Sequence Detail 1921 Not Applicable  
    polypeptide ENSMUSP00000025054 Ensembl | MGI Sequence Detail 325 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 28
      Primer pair 2
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 22
      Gene Ontology 8
      Phenotypes 10
    • Earliest
      J:59911 Yamada N, et al., Cloning and expression of the mouse Pse gene encoding a novel Ets family member. Gene. 2000 Jan 11;241(2):267-74
    • Latest
      J:222721 Rajavelu P, et al., Airway epithelial SPDEF integrates goblet cell differentiation and pulmonary Th2 inflammation. J Clin Invest. 2015 May;125(5):2021-31

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory