Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SOS2
  • Mouse genes Sos2
  • Rat genes Sos2
  • Zfish genes sos2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sos2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	Sos2	IDA		Mouse	PMID:14712229
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	Sos2	IMP		Mouse	PMID:15728722
Molecular Function	GO:0005515	protein binding	SOS2	IPI	UniProtKB:P62993	Human	PMID:14679214
Molecular Function	GO:0005515	protein binding	SOS2	IPI	UniProtKB:Q9UKS6	Human	PMID:14679214
Molecular Function	GO:0005515	protein binding	SOS2	IPI	UniProtKB:Q9Y5X1	Human	PMID:14679214
Molecular Function	GO:0005515	protein binding	SOS2	IPI	UniProtKB:P00519	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	SOS2	IPI	UniProtKB:P16333	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	SOS2	IPI	UniProtKB:P19174	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	SOS2	IPI	UniProtKB:P46108	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	SOS2	IPI	UniProtKB:P62993	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	SOS2	IPI	UniProtKB:P46108	Human	PMID:19380743
Molecular Function	GO:0005515	protein binding	SOS2	IPI	UniProtKB:P62993	Human	PMID:20936779
Molecular Function	GO:0005515	protein binding	SOS2	IPI	UniProtKB:P62993	Human	PMID:21706016
Molecular Function	GO:0005515	protein binding	SOS2	IPI	UniProtKB:P62993	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	SOS2	IPI	UniProtKB:P62993	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	SOS2	IPI	UniProtKB:P62993	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	SOS2	IPI	UniProtKB:P46108	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	SOS2	IPI	UniProtKB:P62993	Human	PMID:7629138
Molecular Function	GO:0005515	protein binding	Sos2	IPI	UniProtKB:Q60631	Mouse	MGI:MGI:3689794|PMID:15953601
Molecular Function	GO:0005515	protein binding	Sos2	IPI	UniProtKB:Q60631	Mouse	MGI:MGI:3688344|PMID:15102471
Molecular Function	GO:0005515	protein binding	Sos2	IPI	UniProtKB:Q8CBW3	Mouse	MGI:MGI:5142386|PMID:11003655
Molecular Function	GO:0005515	protein binding	Sos2	IPI	UniProtKB:Q60631	Mouse	MGI:MGI:5553227|PMID:23452850
Biological Process	GO:0001782	B cell homeostasis	Sos2	IGI	MGI:MGI:98354	Mouse	PMID:24043312
Biological Process	GO:0008286	insulin receptor signaling pathway	Sos2	IDA		Mouse	PMID:7829473
Biological Process	GO:0002260	lymphocyte homeostasis	Sos2	IGI	MGI:MGI:98354	Mouse	PMID:24043312
Biological Process	GO:0051057	positive regulation of small GTPase mediated signal transduction	Sos2	IMP		Rat	PMID:20219970|RGD:5686649
Biological Process	GO:0048793	pronephros development	sos2	IMP	ZFIN:ZDB-MRPHLNO-170614-3	Zfish	PMID:27920155
Biological Process	GO:0048793	pronephros development	sos2	IMP	ZFIN:ZDB-MRPHLNO-170614-2	Zfish	PMID:27920155
Biological Process	GO:2000973	regulation of pro-B cell differentiation	Sos2	IGI	MGI:MGI:98355	Mouse	PMID:24043312
Biological Process	GO:0033081	regulation of T cell differentiation in thymus	Sos2	IGI	MGI:MGI:98354	Mouse	PMID:24043312
Biological Process	GO:0042129	regulation of T cell proliferation	Sos2	IGI	MGI:MGI:98354	Mouse	PMID:24043312
Biological Process	GO:0007264	small GTPase mediated signal transduction	Sos2	IMP		Mouse	PMID:15728722

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern