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Sos2 Gene Detail
Summary
  • Symbol
    Sos2
  • Name
    son of sevenless homolog 2 (Drosophila)
  • Feature Type
    protein coding gene
  • IDs
    MGI:98355
    NCBI Gene: 20663
Location & Maps
more
  • Sequence Map
    Chr12:69583762-69681852 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      98091 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 28.93 cM, cytoband C3-D
  • Mapping Data
    9 experiments
Homology
more
  • Human Ortholog
    SOS2, SOS Ras/Rho guanine nucleotide exchange factor 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SOS2, SOS Ras/Rho guanine nucleotide exchange factor 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NS9, SOS-2
  • Links
    NCBI Gene ID: 6655
    neXtProt AC: NX_Q07890

  • Chr Location
    14q21; chr14:50117128-50231878 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 38253
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: SOS2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human SOS2 associations

Human Disease Mouse Models
       Noonan Syndrome 9; NS9   OMIM: 616559
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotype references
  • All Mutations and Alleles
    3
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    1
  • Genomic Mutations
    1 involving Sos2
  • Incidental Mutations
Mice homozygous for a targeted null mutation exhibit no discernable phenotype; mice are viable and fertile with normal embryonic and adult histopathology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044373 VEGA Gene Model | MGI Sequence Detail 98091 C57BL/6J ±  kb
transcript OTTMUST00000116818 VEGA | MGI Sequence Detail 4512 Not Applicable  
polypeptide OTTMUSP00000065189 VEGA | MGI Sequence Detail 1333 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    409 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000015414 son of sevenless homolog 2
  • PDB
  • InterPro Domains
    IPR000219 Dbl homology (DH) domain
    IPR009072 Histone-fold
    IPR007125 Histone H2A/H2B/H3
    IPR011993 PH domain-like
    IPR001849 Pleckstrin homology domain
    IPR019804 Ras guanine-nucleotide exchange factor, conserved site
    IPR023578 Ras guanine nucleotide exchange factor domain
    IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
    IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
Molecular
Reagents
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  • All nucleic 64
    Genomic 1
    cDNA 63

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-14490
References
more
  • Summaries
    All 43
    Developmental Gene Expression 3
    Gene Ontology 9
    Phenotypes 9
  • Earliest
    J:16346 Bowtell D, et al., Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras. Proc Natl Acad Sci U S A. 1992 Jul 15;89(14):6511-5
  • Latest
    J:229752 Guittard G, et al., Absence of both Sos-1 and Sos-2 in peripheral CD4(+) T cells leads to PI3K pathway activation and defects in migration. Eur J Immunol. 2015 Aug;45(8):2389-95

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory